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Molekulqrnoe modelirowanie i glubokoe obuchenie dlq razrabotki potencial'nyh ingibitorow proniknoweniq VICh-1
LAP Lambert Academic Publishing
Published on 9. April 2025
Book
Paperback/Softback
136 pages
978-620-8-43868-5 (ISBN)
Description
V knige predstawleny algoritmy komp'üternogo konstruirowaniq potencial'nyh lekarstwennyh preparatow na osnowe dannyh o strukture molekulqrnoj misheni, ispol'zuüschie tehnologii glubokogo obucheniq, in silico klik-himii i molekulqrnogo modelirowaniq. Algoritmy aprobirowany w processe generacii i komp'üternogo testirowaniq potencial'nyh ingibitorow proniknoweniq VICh-1, blokiruüschih CD4-swqzywaüschij sajt belka gp120 obolochki wirusa. V ramkah koncepcii in silico klik-himii osuschestwlen komp'üternyj dizajn nowyh ingibitorow proniknoweniq VICh-1 i identificirowany soedineniq, perspektiwnye dlq razrabotki nowyh äffektiwnyh protiwowirusnyh preparatow. Metodami farmakofornogo modelirowaniq obnaruzheny himicheskie soedinenij, imitiruüschie strukturno-funkcional'nye swojstwa anti-VICh antitela N6, kotoroe nejtralizuet do 98% protestirowannyh shtammow VICh-1, wklüchaq 16 iz 20 shtammow, rezistentnyh k drugim antitelam, wzaimodejstwuüschim s CD4-swqzywaüschim uchastkom belka gp120.
More details
Language
Other
Product notice
Paperback (trade)
Unsewn / adhesive bound
Dimensions
Height: 220 mm
Width: 150 mm
Thickness: 9 mm
Weight
221 gr
ISBN-13
978-620-8-43868-5 (9786208438685)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Nikolaew Grigorij Igorewich - kandidat tehnicheskih nauk, nauchnyj sotrudnik Ob#edinennogo instituta problem informatiki Nacional'noj akademii nauk Belarusi (do 2022), w nastoqschee wremq sotrudnik Mezhdunarodnogo instituta molekulqrnoj i kletochnoj biologii w Varshawe. Specializiruetsq w oblasti strukturnoj bioinformatiki.