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Fenotipicheskaq i molekulqrnaq harakteristika ustojchiwosti k antibiotikam
Published on 15. January 2024
Book
Paperback/Softback
192 pages
978-620-7-04417-7 (ISBN)
Description
V dannom issledowanii iz bol'nichnoj sredy bylo wydeleno 306 shtammow gramotricatel'nyh bacill (GNB), 74,51% iz kotoryh sostawlqli änterobakterii. Analiz na chuwstwitel'nost' k antibiotikam pokazal ustojchiwost' k razlichnym semejstwam antibiotikow, osobenno k ¿-laktamnym antibiotikam, hotq imipenem, aminoglikozidy i ftorhinolony byli ochen' äffektiwny. Testy na wyqwlenie beta-laktamaz rasshirennogo spektra dejstwiq (ESBL) ispol'zowalis' dlq harakteristiki 114 shtammow ESBL-produciruüschih Enterobacteriaceae (EBLSE). Analiz plazmidnyh profilej pokazal, chto mul'tirezistentnye shtammy soderzhat ot 1 do 4 plazmid razmerom ot 1 Kb do 170 Kb. Jexperimenty po kon#ügacii pokazali sowmestnyj perenos ustojchiwosti k gentamicinu i kotrimoxazolu na plazmidy razmerom 10Kb, 20Kb, 125Kb ili 165Kb. PCR transkon#ügiruüschih shtammow wyqwila geny bla CTX-M-1, bla TEM i bla SHV, a takzhe geny qnrB. Dannoe issledowanie pokazywaet, chto bol'nichnaq sreda kontaminirowana mul'tirezistentnymi BGN, w chastnosti EBLSE, i chto ona mozhet byt' potencial'nym istochnikom äpidemij, chto pobuzhdaet k prinqtiü rekomendacij w otnoshenii medicinskih uchrezhdenij.
More details
Language
Other
Product notice
Paperback (trade)
Unsewn / adhesive bound
Dimensions
Height: 220 mm
Width: 150 mm
Thickness: 13 mm
Weight
304 gr
ISBN-13
978-620-7-04417-7 (9786207044177)
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Schweitzer Classification
Persons
Awtor imeet stepen' doktora filosofii w oblasti prikladnoj mikrobiologii Uniwersiteta Badzhi Mohtara, Alzhir. D-r Debabza Manel' s 2018 goda qwlqetsq mätrom abilitacionnyh konferencij na kafedre prikladnoj biologii Uniwersiteta Tebessy. Ee issledowaniq poswqscheny ustojchiwosti k ATB u änterobakterij klinicheskogo i pischewogo proishozhdeniq.