Analyzing high-dimensional gene expression and DNA methylation data with R is the first practical book that shows a ``pipeline" of analytical methods with concrete examples starting from raw gene expression and DNA methylation data at the genome scale. Methods on quality control, data pre-processing, data mining, and further assessments are presented in the book, and R programs based on simulated data and real data are included. Codes with example data are all reproducible.
. Provides a sequence of analytical tools for genome-scale gene expression data and DNA methylation data, starting from quality control and pre-processing of raw genome-scale data.
. Organized by a parallel presentation with explanation on statistical methods and corresponding R packages/functions in quality control, pre-processing, and data analyses (e.g., clustering and networks).
. Includes source codes with simulated and real data to reproduce the results. Readers are expected to gain the ability to independently analyze genome-scaled expression and methylation data and detect potential biomarkers.
This book is ideal for students majoring in statistics, biostatistics, and bioinformatics and researchers with an interest in high dimensional genetic and epigenetic studies.
Dr. Hongmei Zhang received her PhD in Statistics in 2003 from the Iowa State University. She was an Associate Professor in Biostatistics at the University of South Carolina before moving to the University of Memphis. She is the recipient of several NIH research grants for her collaborative work in cancer and allergic disease studies, and for her statistical methodology development in variable selection, joint clustering, and Bayesian network.
Genome-Scale Genetic and Epigenetic Data. Methods for Data Pre-Processing. Data Mining. Genetic and Epigenetic Factor Selections. Network Construction and Analyses.
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