Macrocyclic Polyamines

Synthesis and Applications
Wiley-VCH (Verlag)
  • erschienen am 30. Oktober 2017
  • |
  • X, 216 Seiten
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-3-527-80412-2 (ISBN)
The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives

Macrocyclic polyamines are a class of widely used important compounds. This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines, chemical nucleases based on macrocyclic polyamines, the derivatives of macrocyclic polyamines as nano-vector materials, macrocyclic polyamines derivatives for bio-imaging, chemical sensors based on macrocyclic polyamines, and other applications of macrocyclic polyamines.

Macrocyclic Polyamines: Synthesis and Applications includes most of the studies involving macrocyclic polyamines and their derivatives, and may be used as a reference for the researchers in related fields. It offers in-depth coverage of cyclization modes; special procedures for tetraza macrocyclic compounds; diacids-diamines condensation; oxidative DNA cleaving by macrocyclic polyamines; lipids with cationic MPA headgroups; the derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors for bioactive molecules; macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives, electrophoretic separation, and open-tubular CEC; and much more.

?The first book that systematically summarizes the chemistry of macrocyclic polyamines and their derivatives in terms of synthetic methods for their preparation, functionalization, and application in the main fields of chemical sensors, chemical nucleases, drug-delivery, bio-imaging and vector materials
?Provides a comprehensive reference for the researchers working on macrocyclic polyamines
?Offers train of thought in related research fields such as organic chemistry, coordination chemistry, analytical chemistry, supramolecular chemistry, biomaterials, etc.

Macrocyclic Polyamines: Synthesis and Applications will not only provide a reference for the researchers working on macrocyclic polyamines, but also offer opportunities for researchers in related research fields to understand the benefits of these key compounds.
weitere Ausgaben werden ermittelt
Xiao-Qi Yu, PhD, is Changjiang Chair professor and Dean of College of Chemistry, Sichuan University. He has received several awards, including the Distinguished Young Scholars Awarded (2007, National Science Foundation of China).

Ji Zhang, PhD is a professor in College of Chemistry, Sichuan University, China. His research focuses on nano-biomaterials, i.e. design, synthesis and establishment of novel non-viral gene and drug delivery systems and relative structure-activity relationship (SAR) studies.
1. Introduction
1.1 Classification of macrocyclic polyamines
1.2 Properties of macrocyclic polyamines
1.3 Application of macrocyclic polyamines
2. Synthetic Methods of Macrocyclic Polyamines
2.1 Ring-closure modes
2.1.1 The intramolecular cyclization
2.1.2 The 1+1 cyclization
2.1.3 The 2+2 cyclization
2.1.4 Other cyclization modes
2.2 The synthesis of saturated macrocyclic polyamines
2.2.1 Ring closure using sulfonamides
2.2.2 The removal of tosyl protecting groups
2.2.3 The use of easily removable protecting group
2.2.4 Special procedures for tetraza macrocyclic compounds
2.3 Aromatic subunits-containing polyazamacrocycles
2.3.1 Alkylation of sulfonamide salts with dihalomethyl arenes
2.3.2 Metal-catalyzed N-arylation
2.4 Macrocyclic polyimines (Schiff bases)
2.4.1 Metal template reactions
2.4.2 Template free cyclization
2.5 Macrocyclic amides
2.5.1 The crab-like cyclization
2.5.2 Diacids-diamines condensation
2.6 Cryptands
2.6.1 Coupling of the preformed macrocycles
2.6.2 Direct organic synthesis
2.6.3 Spherical cryptands
3. Chemical Nucleases Based on Macrocyclic Polyamines
3.1 Hydrolysis of nucleic acid
3.1.1 Metal complexes of macrocyclic ligands
3.1.2 Metal-free macrocyclic polyamines
3.2 Oxidative cleavage of nucleic acid
3.2.1 Oxidative DNA cleaving by macrocyclic polyamines metallic complexes
3.2.2 Oxidative DNA cleaving by metal-free macrocyclic polyamines
3.3 Summary
4. The Derivatives of Macrocyclic Polyamines as Nano-vector Materials
4.1 Derivatives of MPAs as non-viral gene vectors
4.1.1 Cationic polymers
4.1.2 Lipids with cationic MPA headgroups
4.1.3 Other types of vectors
4.2 Multi-functional materials for both drug delivery and bio-imaging
4.2.1 Gd complexes
4.2.2 64Cu complexes
4.2.3 Miscellaneous
4.3 Summary
5. Macrocyclic Polyamines Derivatives for Bio-imaging
5.1 Typical macrocyclic polyamines for magnetic resonance imaging (MRI)
5.1.1 DOTA and its derivatives
5.1.2 DO3A and its derivatives
5.1.3 PCTA and its derivatives
5.1.4 TETA and NOTA
5.2 Other derivatives of macrocyclic polyamine for MRI
5.2.1 Phosphonate macrocyclic ligands
5.2.2 Ligands with multi-amide arms
5.2.3 Ligands with multi-hydroxy arms
5.2.4 Other types
5.3 MPAs for PET imaging
6. Chemical Sensors/Receptors Based on Macrocyclic Polyamines
6.1 Sensors for metal cations
6.1.1 Zn(II) and Cd(II)
6.1.2 Cu(II) and Pb(II)
6.1.3 Hg(II) , Ag(I) and others
6.2 Receptors for anions
6.2.1 Phosphonates
6.2.2 Amino acids
6.2.3 Other anions
6.3 pH indicator
6.4 Sensors for bioactive molecules
6.4.1 Small molecules
6.4.2 Proteins
6.4.3 Others
6.5 Summary
7. Other Applications of Macrocyclic Polyamines
7.1 Macrocyclic polyamines as ionophores
7.1.1 Macrocyclic polyamines for solvent extraction and membrane transport of metal cations
7.1.2 Macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives
7.2 Macrocyclic polyamines for electrophoretic separation
7.2.1 Polyamine as additive for running solution
7.2.2 Macrocyclic polyamines for open-tubular CEC
7.2.3 Macrocyclic polyamine as the bonded phase for monolithic column

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