This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
Dr. Junjie Xiao is the Vice Dean of the School of Life Science and also of the Medical School (in preparation) at Shanghai University. He is the Associate Editor of the Journal of Cardiovascular Translational Research, BMC Sports and Science, Medicine& Rehabilitation, and a member of the editorial board of BMC Medicine. He is the author or co-author of numerous scientific articles in various journals, including Cell Metabolism, Nature Communications, Annual Review of Genomics and Human Genetics, Circulation, and Theranostics. His major research interest is exercise and myocardial protection, especially using exercise as a platform to identify novel targets for enhancing cardiac regeneration and combating heart failure.
Section I Overview.- 1. An overview of non-coding RNAs and cardiovascular system.- Section II Bioinformatics and Interactions.- 2. Bioinformatics research methodology of non-coding RNAs in cardiovascular diseases.- 3. Online databases and non-coding RNAs in cardiovascular diseases.- 4. Interactions among non-coding RNAs involved in regulating of cardiovascular diseases.- 5. RNA-binding proteins (RBPs) and non-coding RNAs in cardiovascular diseases.- Section III Non-coding RNAs regulation in cardiovascular system.- 6. Involvement of epigenetic control and non-coding RNAs in cardiovascular system.- 7. Non-coding RNAs as Epigenetic Gene Regulators in Cardiovascular Diseases.- 8. Non-coding RNAs and physiological cardiac hypertrophy.- 9. Non-coding RNAs and cardiac regeneration.- 10. Role of non-coding RNA in diabetic cardiomyopathy.- 11. Comprehensive overview of non-coding RNAs in cardiac development.- Section IV Non-coding RNAs and Cardiovascular diseases.- 12. Non-coding RNAs and heart failure.- 13. Non-coding RNAs and pathological cardiac hypertrophy.- 14. Non-coding RNAs and cardiac aging.- 15. Non-coding RNAs and ischemic cardiovascular diseases.- 16. Non-coding RNAs and coronary artery disease.- 17. Non-coding RNAs and cardiac arrhythmias.- 18. Non-coding RNA and cardiac electrophysiological disorders.- 19. Non-coding RNAs and atrial fibrillation.- 20. Y RNAs: Biogenesis, Function and Implications for the Cardiovascular System.- 21. Translational potential of non-coding RNAs for cardiovascular disease.- Section V Potential biomarkers and Therapeutic implications.- 22. Circulating non-coding RNAs and Cardiovascular Diseases.- 23. Small interfering RNAs and RNA therapeutics in Cardiovascular Diseases.- Section VI Future Prospects.- 24. Prospective advances in non-coding RNAs investigation.