Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men. Chapters covering neuroendocrine control of testicular function, Leydig cell function, spermatogenesis, and normal and delayed puberty open the book. The focus then turns to the pathophysiology and treatment of hypogonadism and other forms of testicular dysfunction, such as Klinefelter syndrome, cryptorchidism, and disorders of the pituitary, as well as reproductive and endocrine consequences of cancer treatment, environmental factors, obesity and aging. Next are chapters that describe the available options for androgen replacement therapy, and the outcomes when men with hypogonadism of various causes are treated with testosterone, as well as a chapter devoted to current approaches to stimulating spermatogenesis in gonadotropin-deficient men. Highly practical and updated with the latest available data, this second edition of Male Hypogonadism: Basic, Clinical and Therapeutic Principles cogently presents a large body of scientific information on male reproductive endocrinology to provide a thorough understanding of the pathophysiology, clinical characteristics, and treatments for disorders that adversely affect testicular function.
Stephen J. Winters, MD, Professor of Medicine, Chief, Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, KY, USA
Ilpo Huhtaniemi, MD, PhD, Professor Emeritus of Reproductive Endocrinology, Institute of Reproductive and Developmental Biology, Department of Surgery & Cancer, Imperial College London, Hammermith Campus, London, UK
Neuroendocrine Control of Human Testicular Function.- The Human Leydig Cell.- Human Spermatogenesis and its Regulation.- Normal and Delayed Puberty.- Congenital Hypogonadotropic Hypogonadism in Males: Clinical Features and Pathophysiology.- Male Hypogonadism Resulting From Mutations in the Genes for the Gonadotropin Subunits and their Receptors.- Hypogonadism in Males with Congenital Adrenal Hyperplasia.- Male Hypogonadism Due to Disorders of the Pituitary and Suprasellar Region.- Klinefelter Syndrome and Other Forms of Primary Testicular Failure.- The Undescended Testis.- Male Hypogonadism and Liver Disease.- Male Hypogonadism Due to Cancer and Cancer Treatments.- Exercise and Male Hypogonadism: Testosterone, the Hypothalamic-Pituitary- Testicular Axis, and Exercise Training.- Environmental Causes of Testicular Dysfunction.- Sex Hormone-binding Globulin and the Metabolic Syndrome.- An Ensemble Perspective of Aging-Related Hypoandrogenemia in Men.- Obesity and Aging in Late-onset Hypogonadism.- Androgen Replacement Therapy in Hypogonadal Men.- Androgen Therapy for Hypogonadism in Men with Chronic Illnesses.- Stimulation of Spermatogenesis in Hypogonadotropic Men.