Metabolomics

Practical Guide to Design and Analysis
 
 
Chapman & Hall/CRC (Verlag)
  • 1. Auflage
  • |
  • erschienen am 19. August 2019
  • |
  • 290 Seiten
 
E-Book | ePUB ohne DRM | Systemvoraussetzungen
978-1-315-35348-7 (ISBN)
 

Metabolomics is the scientific study of the chemical processes in a living system, environment and nutrition. It is a relatively new omics science, but the potential applications are wide, including medicine, personalized medicine and intervention studies, food and nutrition, plants, agriculture and environmental science. The topics presented and discussed in this book are based on the European Molecular Biology Organization (EMBO) practical courses in metabolomics bioinformatics taught to those working in the field, from masters to postgraduate students, PhDs, postdoctoral and early PIs. The book covers the basics and fundamentals of data acquisition and analytical technologies, but the primary focus is data handling and data analysis. The mentioning and usage of a particular data analysis tool has been avoided; rather, the focus is on the concepts and principles of data processing and analysis. The material has been class-tested and includes lots of examples, computing and exercises.

Key Features:

    • Provides an overview of qualitative /quantitative methods in metabolomics

    • Offers an introduction to the key concepts of metabolomics, including experimental design and technology

    • Covers data handling, processing, analysis, data standards and sharing

    • Contains lots of examples to illustrate the topics

    • Includes contributions from some of the leading researchers in the field of metabolomics with extensive teaching experiences
    1. Auflage
    • Englisch
    • London
    • |
    • Großbritannien
    Taylor & Francis Ltd
    • Für Beruf und Forschung
    • |
    • Für höhere Schule und Studium
    65 schwarz-weiße Abbildungen, 4 schwarz-weiße Fotos, 61 schwarz-weiße Zeichnungen, 6 schwarz-weiße Tabellen
    • 4,10 MB
    978-1-315-35348-7 (9781315353487)
    weitere Ausgaben werden ermittelt

    Ron Wehrens was an associate professor at the Radboud University Nijmegen (Netherlands) before founding the Biostatistics unit at the Fondazione Edmund Mach, San Michele all'Adige (Italy). Currently, he is Business Unit Manager at Biometris, Wageningen University & Research, Netherlands.

    Reza Salek* has worked in the past in the University of Cambridge and The European Molecular Biology Laboratory European Bioinformatics Institute (EMBL EBI), Cambridge UK. He is currently scientist at The International Agency for Research on Cancer, an intergovernmental agency forming part of the World Health Organization of the United Nations, Lyon France.

    *Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization

    Preface

    Overview of Metabolomics - Oscar Yanes, Reza Salek, Igor Marin, Marta Cascante

    Study Design and Preparation - Pietro Franceschi, Oscar Yanes and Ron Wehrens

    Measurement Technologies - Oscar Yanes, Katherine Hollywood, Roland Mumm, Maria Vinaixa, Naomi Rankin, Ron Wehrens and Reza Salek

    Mass Spectrometry Data Processing - Steffen Neumann, Oscar Yanes, Roland Mumm, Pietro Franceschi

    Nuclear Magnetic Resonance Spectroscopy Data Processing - Maria Vinaixa, Naomi Rankin, Jeremy Everett and Reza Salek

    Statistics: the essentials - Ron Wehrens and Pietro Franceschi

    Data fusion in metabolomics - Johan A. Westerhuis, Frans van der Kloet, Age K. Smilde

    Genome-scale metabolic networks - Clément Frainay & Fabien Jourdan

    Metabolic flux - Igor Marín de Mas and Marta Cascante

    Data Sharing and Standards

    Conclusion

    Appendix: Metabolic and transcriptional response of Arabidopsis thaliana wildtype and mutants to Phytophthora infestans - Tilo Lübken, Michaela Kopischke, Kathrin Geissler, Lore Westphal, Dierk Scheel, Steffen Neumann, Sabine Rosahl

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