This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.
The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.
Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide.
This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.
Professor Saman Warnakulasuriya OBE has extensive experience in conducting international collaborative research projects including clinical trials and a strong expertise of managing Head and Neck cancers. He has championed ways to relocate his clinical follow up studies and experimental data from the laboratory into the real-world. His contributions as the Director of World Health Organization Collaborating Centre for Oral Cancer has over a decade catalysed a global collaborative effort to improve adherence to high standards of clinical care in his speciality around the world.
His experimental studies have reported on clinical adjunctive aids and novel ways of stratifying patients at high risk and reported on several biomarkers for the prediction of risk of malignant transformation from precancer to cancer. He has published over 260 peer reviewed papers mostly on oral cancer and premalignancy and several systematic reviews and book chapters. He is the recipient of several key scientific awards as a distinguished scientist and for his distinguished service to King's College London for over 25 years.
Chapter 1. Introduction- The biology and pathology of squamous cell carcinomata in the head and neck
Chapter 2 Cancer Stem Cells - Biopathology with reference to Head & Neck Cancers
Chapter 3 Hypoxia in head and neck cancer
Chapter 4 Genetic aberrations and molecular pathways in head and neck cancer
Chapter 5 p53 in Head and Neck Squamous Cell Carcinoma
Chapter 6 Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck
Chapter 7 Targeting the mTOR signaling circuitry in head and neck cancer
Chapter 8 Survivin as a Therapeutic Target in Squamous Cell Carcinoma
Chapter 9 MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma
Chapter 10. Envoi - An appraisal of Targeted Therapies for Head and Neck Cancer