Animal Biotechnology

Models in Discovery and Translation
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 4. November 2013
  • |
  • 668 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-391434-7 (ISBN)
 

Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field.

Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences.


  • Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseases
  • Provides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 34,63 MB
978-0-12-391434-7 (9780123914347)
0123914345 (0123914345)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Animal Biotechnology: Models in Discovery and Translation
  • Copyright
  • Dedication
  • Contents
  • Contributors
  • Foreword
  • Preface
  • Acknowledgments
  • Section I - Human Diseases: In Vivo and In Vitro Models
  • Chapter 1 - Drosophila: A Model for Biotechnologists
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • HISTORY
  • PRINCIPLE
  • METHODOLOGY
  • PROTOCOLS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • DROSOPHILA MODELS OF HUMAN DISEASE
  • DROSOPHILA-BASED THERAPEUTIC PEPTIDE PRODUCTION
  • WORLD WIDE WEB RESOURCES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 2 - Animal Models of Tuberculosis
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • COMPARATIVE PATHOLOGY OF TB IN HUMANS AND ANIMALS
  • PATHOGEN DIVERSITY: CROSSING SPECIES BARRIERS
  • HOST DIVERSITY: FUNDAMENTAL PROCESSES AND FINE TUNING
  • ANIMAL MODELS OF TB: LIMITS AND LESSONS
  • VARIOUS ANIMAL MODELS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • PROTOCOLS
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 3 - Animal Models for Neurodegenerative Disorders
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • INTRODUCTION
  • PRINCIPLES
  • METHODOLOGY
  • EXAMPLES AND THEIR APPLICATIONS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 4 - Epigenetics and Animal Models: Applications in Cancer Control and Treatment
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • HISTORY: LANDSCAPE OF EPIGENETICS
  • PRINCIPLE
  • METHODOLOGY
  • PROTOCOLS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 5 - Development of Mouse Models for Cancer Research
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • HISTORY
  • PRINCIPLE
  • METHODOLOGY
  • EXAMPLES WITH APPLICATIONS
  • CHECKLIST FOR A SUCCESSFUL IN VIVO EXPERIMENT
  • PROTOCOLS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • FURTHER READING
  • Chapter 6 - Human Papillomavirus (HPV): Diagnosis and Treatment
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • CANCER OVERVIEW
  • CLASSIFICATION OF CANCER
  • CANCER-CAUSING AGENTS
  • CERVICAL CANCER
  • PREVALENCE AND EPIDEMIOLOGY OF CERVICAL CANCER
  • ETHICAL ISSUES
  • PUBLIC HEALTH CONCERNS WITH SCREENING IMPLEMENTATION
  • PUBLIC HEALTH CONCERNS ABOUT VACCINE IMPLEMENTATION
  • TREATMENT
  • TRANSLATIONAL SIGNIFICANCE
  • PROPHYLACTIC HPV VACCINES
  • THERAPEUTIC HPV VACCINES
  • GENETIC-BASED DNA VACCINES
  • ISSUES/UNANSWERED QUESTIONS ASSOCIATED WITH HPV VACCINES
  • FUTURE PROSPECTS OF HPV WITH RESPECT TO BIOTECHNOLOGY
  • CONCLUSION
  • KEY POINTS
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • Long Answer Questions
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 7 - Human DNA Tumor Viruses and Oncogenesis
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • TRANSFORMATION AND ONCOGENESIS
  • HISTORY OF HUMAN DNA TUMOR VIRUSES AND CANCER
  • CURRENT RESEARCH PERSPECTIVES
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 8 - Animal Models for Human Disease
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • RHEUMATOID ARTHRITIS
  • MULTIPLE SCLEROSIS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 9 - HIV and Antiretroviral Drugs
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • DISCOVERY AND ORIGIN OF HIV
  • HISTORY OF HIV AND AIDS
  • GLOBAL DISEASE BURDEN
  • CLINICAL STAGES OF HIV
  • MOLECULAR BIOLOGY OF HIV
  • REPLICATION: STEPS AND DRUG TARGETS
  • ANTIRETROVIRAL DRUGS
  • HIV RESISTANCE AND ANTIRETROVIRAL TREATMENT
  • NEW TYPES OF ANTIRETROVIRALS
  • METHODOLOGY AND PRINCIPLES
  • NEUROAIDS: AN EMERGING HEALTH CONCERN
  • BONE MARROW TRANSPLANTATION: A PROBABLE CURE FOR HIV
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 10 - Animal Biotechnology as a Tool to Understand and Fight Aging
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • INTRODUCTION
  • PRINCIPLE
  • METHODOLOGY: MEASUREMENT OF FREE RADICALS AND METHODS TO MONITOR AGING
  • COMMON LABORATORY ANIMAL EXPERIMENTAL MODELS FOR AGING RESEARCH
  • POLYPHENOLS AS AN AGENT TO FIGHT AGING
  • ANIMAL BIOTECHNOLOGY AS A TOOL TO UNDERSTAND AND FIGHT AGING
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Section II - Animal Biotechnology: Tools and Techniques
  • Chapter 11 - Multicellular Spheroid: 3-D Tissue Culture Model for Cancer Research
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • MULTICELLULAR TUMOR SPHEROIDS
  • HISTORICAL FACTS TOWARDS THE DEVELOPMENT OF TISSUE CULTURE TECHNOLOGY FROM 2-D AND 3-D CULTURES
  • TECHNIQUES FOR THE GENERATION OF SPHEROIDS
  • PROTOCOL FOR TUMOR SPHEROID GENERATION
  • DRUG TREATMENT PROTOCOL
  • PARAMETERS TO MONITOR DRUG EFFICACY IN 3-D CULTURES
  • RADIATION RESPONSE OF TUMOR CELLS AND ITS MODIFICATIONS
  • RESPONSE TO ANTICANCER DRUGS
  • RESPONSE TO PHOTODYNAMIC THERAPY
  • RESPONSE TO ANTI-ANGIOGENESIS THERAPEUTICS
  • EVALUATION OF RESPONSE TO IMMUNOTHERAPY
  • APPLICATION OF 3-D CULTURES IN OTHER DISEASES
  • CONCLUSIONS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 12 - Animal Tissue Culture: Principles and Applications
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • INTRODUCTION
  • DEVELOPMENT OF ANIMAL CELL CULTURE
  • BASIC CONCEPT OF CELL CULTURE
  • TYPES OF CELL CULTURE
  • CELL LINE
  • GROWTH CYCLE
  • MONITORING CELL GROWTH
  • CELL VIABILITY
  • CULTURE MEDIA
  • CHARACTERIZATION OF CELL LINES
  • ADVANTAGES OF ANIMAL CELL CULTURE
  • DISADVANTAGES OF ANIMAL CELL CULTURE
  • ETHICAL ISSUES
  • USE OF FETAL BOVINE SERUM IN ANIMAL CULTURE OF MEDIA
  • TRANSLATIONAL SIGNIFICANCE
  • ANTI-VIRAL VACCINES
  • RECOMBINANT THERAPEUTIC PROTEINS
  • GENE THERAPY
  • BIOPESTICIDES
  • MONOCLONAL ANTIBODIES
  • STEM CELLS
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 13 - Concepts of Tissue Engineering
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • HISTORY
  • BASIC APPROACH TO TISSUE ENGINEERING: PRINCIPLES AND METHODOLOGY
  • SCAFFOLD DESIGN
  • MATERIALS FOR SCAFFOLDS
  • SCAFFOLD FABRICATION METHODS
  • EXAMPLES OF TISSUE-ENGINEERED ORGANS
  • TISSUE ENGINEERING USING STEM CELLS
  • ISSUES AND CHALLENGES
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 14 - Nanotechnology and Its Applications to Animal Biotechnology
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • METHODOLOGIES
  • EXAMPLES OF NANOTECHNOLOGY APPLICATIONS TO ANIMAL BIOTECHNOLOGY
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 15 - Antibodies: Monoclonal and Polyclonal
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • TISELIUS AND KABAT'S EXPERIMENT
  • HISTORY
  • ELUCIDATION OF IMMUNOGLOBULIN STRUCTURE
  • IMMUNOGLOBULIN G: A PROTOTYPE FOR IMMUNOGLOBULIN
  • POLYCLONAL ANTIBODY VERSUS MONOCLONAL ANTIBODY
  • NAMING MONOCLONAL ANTIBODIES
  • ANTIBODIES AS THERAPEUTICS: ADVERSE EFFECTS
  • APPLICATIONS OF ANTIBODIES
  • METHODOLOGY, PRINCIPLES, AND PROTOCOLS
  • BIOCHEMICAL PATHWAY: HYBRIDOMA SELECTION
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 16 - Molecular Markers: Tool for Genetic Analysis
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • METHODOLOGY
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • FURTHER READING
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 17 - Gene Expression: Analysis and Quantitation
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • PRINCIPLES
  • METHODOLOGY
  • PROTOCOLS
  • EXAMPLES
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 18 - Ribotyping: A Tool for Molecular Taxonomy
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • HISTORICAL DEVELOPMENTS IN BACTERIAL TAXONOMY
  • TYPING METHODS USED FOR BACTERIAL SYSTEMATICS
  • BASIS OF USING RRNA AND RRNA GENES AS TAXONOMIC TOOLS
  • DIFFERENT TECHNIQUES OF RIBOTYPING
  • LIMITATIONS OF RIBOTYPING
  • FUTURE PERSPECTIVES
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 19 - Next Generation Sequencing and Its Applications
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • HISTORY OF DNA SEQUENCING
  • GENERATION OF SEQUENCING TECHNOLOGIES
  • PRINCIPLE OF SANGER SEQUENCING VS. NEXT GENERATION SEQUENCING
  • NEXT GENERATION/SECOND GENERATION TECHNOLOGIES
  • THIRD GENERATION SEQUENCING TECHNOLOGIES
  • OTHER/4TH GENERATION SEQUENCING TECHNOLOGIES
  • DOWNSTREAM BIOINFORMATICS
  • GENERAL PRINCIPLES OF NGS METHODS IN VARIOUS APPLICATIONS
  • ANIMAL BIOTECHNOLOGY AND THE CATTLE GENOME
  • APPLICATIONS OF NGS IN ANIMAL BIOTECHNOLOGY
  • APPLICATIONS OF NGS IN HUMAN HEALTH
  • FUTURE PERSPECTIVES
  • CHALLENGES
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 20 - Biomolecular Display Technology: A New Tool for Drug Discovery
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • INTRODUCTION
  • PRINCIPLE
  • NECESSITY: SMALL MOLECULE VS. BIOMOLECULAR (BIOLOGICS) DRUGS
  • METHODOLOGY: BIOMOLECULAR DISPLAY TECHNOLOGIES
  • CONCLUSION AND FUTURE PERSPECTIVES
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANWERS QUESTIONS
  • ANSWERS TO SHORT ANSWERS QUESTIONS
  • Chapter 21 - In Silico Models: From Simple Networks to Complex Diseases
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • BIOINFORMATICS IN ANIMAL BIOTECHNOLOGY
  • BIOINFORMATICS AND SYSTEMS BIOLOGY
  • COMMON COMPUTATIONAL METHODS IN SYSTEMS BIOLOGY
  • EXPERIMENTAL METHODS IN SYSTEMS BIOLOGY
  • PROTEIN-PROTEIN INTERACTIONS (PPIS)
  • TRANSCRIPTIONAL CONTROL NETWORKS
  • SIGNAL TRANSDUCTION NETWORKS
  • MATHEMATICAL MODELING TECHNIQUES
  • THE CONCEPT OF MODELING
  • IN SILICO MODELS OF CELLS
  • APPLICATIONS OF IN SILICO DISEASE MODELING IN PRACTICE
  • CONCLUSION
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Section III - Animal Biotechnology: Applications and Concerns
  • Chapter 22 - Transgenic Animals and their Applications
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • INTRODUCTION
  • CREATING TRANSGENIC ANIMALS
  • TRANSGENIC ANIMALS AS DISEASE MODELS
  • TRANSGENIC ANIMALS AS BIOLOGICAL MODELS
  • TRANSGENIC ANIMALS AS XENOTRANSPLANTERS
  • TRANSGENIC ANIMALS AS FOOD SOURCES
  • TRANSGENIC ANIMALS FOR DRUG AND INDUSTRIAL PRODUCTION
  • TRANSGENIC ANIMALS' IMPACT ON THE ENVIRONMENT
  • PATENTING TRANSGENIC ANIMALS
  • ETHICAL ISSUES
  • FDA GUIDELINES ON GENETICALLY ENGINEERED ANIMALS
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 23 - Stem Cells: A Trek from Laboratory to Clinic to Industry
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • HISTORY OF STEM CELL RESEARCH
  • WHAT ARE STEM CELLS AND WHY ARE THEY IMPORTANT?
  • WHAT MAKES STEM CELLS SPECIAL?
  • DIFFERENTIATION POTENTIAL/POTENCY OF STEM CELLS
  • ARE STEM CELLS IMMORTAL?
  • CHARACTERISTICS OF STEM CELLS
  • WHERE TO FIND STEM CELLS?
  • WHERE DO STEM CELLS COME FROM?
  • HOW ARE STEM CELLS IDENTIFIED, ISOLATED, AND CHARACTERIZED?
  • THE STEM CELL NICHE
  • GROWING STEM CELLS IN THE LABORATORY
  • IPSCS: A STEM CELL RESEARCH BREAKTHROUGH
  • CANCER STEM CELLS (CSCS)
  • PROTOCOLS FOR HOECHST 33342 OR DCV STAINING AND STEM CELL PURIFICATION
  • ETHICAL ISSUES
  • STEM CELL RESEARCH AT THE CROSSROADS OF RELIGION AND SOCIAL ISSUES
  • Translational Significance
  • THERAPEUTIC POTENTIAL OF STEM CELLS: A NEW AGE IN HEALTH CARE
  • HOW ARE STEM CELLS USED IN CELL-BASED REGENERATIVE THERAPIES?
  • CAN STEM CELLS BE USED TO FIND NEW MEDICINES?
  • POTENTIAL USES OF STEM CELLS
  • STEM CELL BANKING
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 24 - Role of Cytogenetics and Molecular Genetics in Human Health and Medicine
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • CYTOGENETICS: AN OVERVIEW
  • CHROMOSOME MORPHOLOGY AND CLASSIFICATION
  • CHROMOSOMAL DISORDERS
  • METHODOLOGY: APPLICATION OF DIFFERENT CYTOGENETIC TECHNIQUES IN DIAGNOSIS OF GENETIC DISORDERS
  • MOLECULAR GENETICS: AN OVERVIEW
  • METHODOLOGY: APPLICATION OF DIFFERENT MOLECULAR TECHNIQUES FOR DIAGNOSIS OF GENETIC DISORDERS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 25 - Antibodies and Their Applications
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • IMMUNODIAGNOSTICS: ROLE OF ANTIBODIES
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • PROS
  • CONS
  • WEBSITES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 26 - Vaccines: Present Status and Applications
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • INTRODUCTION
  • TYPES OF VACCINES
  • MOLECULAR FARMING USING PLANTS AS BIO-REACTORS
  • ROLE OF ADJUVANTS
  • IMMUNE-STIMULATING COMPLEXES (ISCOMS)
  • PROTOCOL FOR THE DEVELOPMENT OF VACCINES
  • FUTURE CHALLENGES IN VACCINE DEVELOPMENT
  • ETHICAL ISSUES
  • MANDATES
  • VACCINE RESEARCH AND TESTING
  • INFORMED CONSENT
  • ACCESS ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 27 - Safety Assessment of Food Derived from Genetically Modified Crops
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • RATIONALE FOR THE ALLERGENICITY ASSESSMENT OF GM FOODS
  • MECHANISM OF FOOD PROTEIN-INDUCED ALLERGENICITY
  • SIMULATED GASTRIC FLUID (SGF) ASSAY
  • SIMULATED INTESTINAL FLUID (SIF) ASSAY
  • THERMAL TREATMENT ASSAY
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 28 - Nanotechnology and Detection of Microbial Pathogens
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • INDICATORS OF MICROBIAL WATER QUALITY
  • NEED FOR DETECTION OF WATER- AND FOOD-BORNE PATHOGENS
  • CONVENTIONAL METHODS TO DETECT FECAL INDICATOR ORGANISMS AND OTHER PATHOGENIC BACTERIA
  • MOLECULAR METHODS BASED ON GENETIC SIGNATURE OF TARGET PATHOGEN
  • NANOTECHNOLOGY AND ITS PROMISE
  • HISTORY
  • DETECTION PRINCIPLE
  • METHODOLOGY
  • EXAMPLES
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • FUTURE APPROACHES
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 29 - Biotechnological Exploitation of Marine Animals
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • INTRODUCTION
  • MARINE BIORESOURCES AND BIOTECHNOLOGY
  • GENETIC ENGINEERING AND ITS APPLICATION IN AQUACULTURE
  • MARINE ORNAMENTAL FISH TRADE AND CHROMOSOMAL MANIPULATION
  • ADVANCES IN MARICULTURE
  • MARINE GENOMICS
  • DISEASE DIAGNOSIS OF CULTIVABLE ANIMALS
  • THERAPEUTICS FROM MARINE ANIMALS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • FUTURE DIRECTIONS
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 30 - Herbal Medicine and Biotechnology for the Benefit of Human Health
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • METHODOLOGY
  • BIOTECHNOLOGICAL APPROACHES FOR HERBAL DRUG PRODUCTION
  • OPPORTUNITIES AND CHALLENGES
  • CONCLUSIONS AND OUTLOOK
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 31 - Perspectives on the Human Genome
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • HISTORY AND METHODS
  • Introduction
  • HUMAN GENOME SEQUENCING PROJECT
  • PRINCIPLE
  • METHODOLOGY
  • EXAMPLES WITH APPLICATIONS
  • ETHICAL ISSUES
  • TRANSLATIONAL SIGNIFICANCE
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • ABBREVIATIONS
  • GLOSSARY
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Chapter 32 - Ethical Issues in Animal Biotechnology
  • SUMMARY
  • WHAT YOU CAN EXPECT TO KNOW
  • History and Methods
  • INTRODUCTION
  • A BRIEF OVERVIEW OF ETHICAL THOUGHTS AND PRINCIPLES
  • PRINCIPLES
  • METHODOLOGY
  • APPLICATION OF ETHICS IN ANIMAL BIOTECHNOLOGY
  • ETHICAL CONCERNS IN ANIMAL BIOTECHNOLOGY
  • SOME CHALLENGING ETHICAL ISSUES IN ANIMAL BIOTECHNOLOGY
  • Translational Significance
  • HUMAN THERAPEUTIC CLONING AND OTHER TECHNIQUES IN ANIMAL BIOTECHNOLOGY
  • CONCLUSIONS
  • WORLD WIDE WEB RESOURCES
  • REFERENCES
  • GLOSSARY
  • ABBREVIATIONS
  • LONG ANSWER QUESTIONS
  • SHORT ANSWER QUESTIONS
  • ANSWERS TO SHORT ANSWER QUESTIONS
  • Index
  • Color Plates

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