This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field.
The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications.
The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.
Prof. Dr. med. Dierk Thomas is Associate Professor at the University of Heidelberg and Head of the Cardiac Electrophysiology Department, Medical University Hospital, University of Heidelberg, Germany.
Dr. Carol Ann Remme is Associate Professor and Principal Investigator at the Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
Part A: (Dys)function of cardiac ion channels
2. The electrophysiological basis of cardiac conduction and repolarization (include also: Distribution of ion channels in the heart (atrium vs ventricle, conduction system versus working myocardium, Purkinje, transmural distribution))
Jules Hancox (University of Bristol, UK; Jules.Hancox@bristol.ac.uk)
3. Novel insights into ion channel complexity and diversity: relevance for cardiac channelopathies (interacting proteins, subcellular distribution, non-electrogenic effects, electro-mechanical overlap, impact on other organs, etc).
Hugues Abriel (Bern, CH)
4. Cardiac sodium channel structure and (dys)function
C.A. Remme (Amsterdam, NL)
5. Potassium channels in the heart: structure and (dys)function
Nicole Schmitt (Copenhagen, Denmark; firstname.lastname@example.org)
6. Calcium channels and their roles in cardiac electrophysiology
Niels Voigt (Göttingen; Germany; email@example.com)
7. HCN channels and cardiac pacemaking
Mirko Baruscotti (Department of Biomolecular Sciences and Biotechnology, University of Milan, Italy; firstname.lastname@example.org)
8. (Dys)regulation of ionic homeostasis: relevance for cardiac arrhythmias (including ryanodine receptor channelopathies, etc)
Luigi Venetucci (Institute of Cardiovascular Sciences, University of Manchester, UK; email@example.com)
Part B: Cardiac channelopathies: clinical and genetic findings
9. Long QT syndrome (including Timothy syndrome), short QT syndrome
Lia Crotti (Department of Molecular Medicine, University of Pavia, Pavia, Italy; firstname.lastname@example.org)
10. Brugada syndrome
Koonlawee Nademanee (The Pacific Rim Electrophysiology Research Institute, Los Angeles, USA; email@example.com)
11. Sinus node disease and Lev-Lenègre syndrome-progressive cardiac conduction disease
Patrick Schweizer (Heidelberg, Germany; firstname.lastname@example.org)
12. Catecholaminergic polymorphic ventricular tachycardia
Bjorn C. Knollmann (Vanderbilt University School of Medicine, Nashville, USA; email@example.com)
13. Idiopathic ventricular fibrillation and early repolarization
Pieter Postema (Academic Medical Center, Amsterdam, The Netherlands; firstname.lastname@example.org)
14. Atrial fibrillation
Dierk Thomas (Heidelberg, Germany)
15. Pulmonary arterial hypertension
Horst Olschewski (Ludwig Boltzmann Institute for Lung Vascular Research, Medical University of Graz, Austria; email@example.com)
16. Genetic testing for inheritable cardiac channelopathies
Julien Barc (l'institut du thorax, Nantes, France; firstname.lastname@example.org)
Part C: Research into cardiac channelopathies: new avenues
17. Novel imaging techniques in cardiac ion channel research
Eli Rothenberg (Department of Biochemistry and Molecular Pharmacology, New York, USA; Eli.Rothenberg@nyumc.org)
18. iPSC-CM: towards personalized therapeutic strategies?
Alessandra Moretti (Technical University of Munich, Germany;
19. Computational modeling in cardiac channelopathy research
Blanca Rodriguez (Department of Computer Science, University of Oxford, Oxford, UK; email@example.com)
20. Identification of disease modifiers in cardiac channelopathies
Elisabeth Lodder/Connie Bezzina (Academic Medical Center, Amsterdam, The Netherlands; firstname.lastname@example.org)
21. Transgenic animal models of cardiac channelopathies - benefits and limitations
Katja Odening (Universitäts-Herzzentrum Freiburg, Germany; email@example.com)