This volume records the proceedings of an International Symposium on The Structure and Function of Gangliosides, held at Le Bischenberg, Alsace, France, in April 23-27, 1979. The meeting was convened to get a comprehensive view of the immense activity that had occurred in the field since the previous conference on gangliosides held at Mont Sainte-Odile, ~lsace, France, in April 1973. At a conference on Enzymes of Lipid Metabolism held at the same place in April, 1977, several of the participants from the first ganglioside conference in 1973 met again. All previous participants agreed that the first meeting with its many frank and stimulating lectures, round tables and informal discussions had been of tremendous importance for the activity in the field and led to many personal contacts and a warm friendship among the ganglioside researchers. The success of the first meeting must be ascribed largely to one single man, PAUL MANDEL. Therefore, we decided to dedicate the next ganglioside conference to hirn and I was given the privilege to arrange the meeting together with him and staff members at Centre de Neurochirnie, Strasbourg. The Symposium on The Structure and Function of Gangliosides was arranged to honour PAUL MANDEL for his unique and never failing efforts to promote and strengthen international col laboration in all fields of neurochemistry.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
62
62 s/w Abbildungen
XI, 571 p. 62 illus.
Dateigröße
ISBN-13
978-1-4684-7844-0 (9781468478440)
DOI
10.1007/978-1-4684-7844-0
Schweitzer Klassifikation
Chemical Structure of Gangliosides.- Introductory Remarks on Chemical Structures of Gangliosides.- Ganglioside Designation.- A New Approach to the Analysis of Ganglioside Molecular Species.- Isolation and Separation of Gangliosides on a New Form of Glass Bead Ion Exchanger.- Structures of Some New Complex Gangliosides of Fish Brain.- Structural Fingerprinting of Gangliosides and Other Glycoconjugates by Mass Spectrometry.- Mass Spectra and NMR Spectra of Gangliosides Containing Fucose.- Trifluoroacetolysis, a New Method for Structural Studies of Glycolipids.- High Resolution 1H-NMR Spectroscopy of Carbohydrate Structures.- Enzymic Degradation of Gangliosides.- Characterization of Micellar and Liposomal Dispersions of Gangliosides and Phospholipids.- Structural Modifications of Gangliosides in Synaptic Membranes.- Hydrolysis of Gangliosides in Micellar and Liposomal Dispersion by Bacterial Neuraminidases.- Distribution of Gangliosides in Tissues, Subcellular Fractions, Cells and Fluids.- Brain and Retinal Ganglioside Composition from Different Species Determined by TLC and HPTLC.- Glycolipids and Cell Differentiation.- Gangliosides of the CNS Myelin Membrane.- Gangliosides in Fish Brain.- Gangliosides of Brain and of Extraneural Tissues: Structural Relationship to Protein-Linked Glycans.- A Sensitive Assay for Gangliosides in the Subnanomole Range.- Metabolism of Gangliosides.- Introductory Remarks on Ganglioside Metabolism.- Biosynthesis of Gangliosides in Tissues.- Sialyltransferase Activities in Two Neuronal Models: Retina and Cultures of Isolated Neurons.- Sialyltransferases in Young Rat Brain.- Cell Biological and Immunological Significance of Ganglioside Changes Associated with Transformation.- Gangliosides, Neuraminidase and Sialyltransferase at the Nerve Endings.- "Neuraminidase-Resistant" Sialic Acid Residues of Gangliosides.- The Specificity of Human N-Acetyl-?-D-Hexosaminidases Towards Glycosphingolipids is Determined by an Activator Protein.- The Specificity of ?-Galactosidase in the Degradation of Gangliosides.- Immunological Methods for the Identification of Gangliosides.- Preparation and Properties of Antibodies to Gangliosides.- Antibodies to Total Brain Gangliosides: Titer and Specificity of Antisera.- Perturbation of CNS Functions by Antibodies to Gangliosides. Speculations on Biological Roles of Ganglioside Receptors.- Immunoassays Based on Plastic-Adsorbed Gangliosides.- Immunological Properties of Glycolipids Including Some Gangliosides in Mammalian Erythrocyte Membranes.- Detection of Antibodies to Gangliosides in Pathologic Human Sera. Serum-Sickness Type Heterophile Antibodies.- Sialidoses and Sialidases.- Sialidoses, New Types of Inborn Diseases.- Sialidoses (Mucolipidoses), Clinical Pictures.- Sialidase in Brain and Fibroblasts in Three Patients with Different Types of Sialidosis.- Neuraminidase Studies in Sialidosis.- Function of Gangliosides (Receptor Properties, Involvement in Neurotransmission).- Saccharide Traffic Signals in Receptor-Mediated Endocytosis and Transport of Acid Hydrolases.- Gangliosides as Receptors for Bacterial Toxins and Sendai Virus.- Isolation of Cholera Toxin by Affinity Chromatography on Porous Silica Beads with Covalently Coupled Ganglioside Gm1.- The Interaction Between Gangliosides and Interferon.- Thyrotropin Receptors and Gangliosides.- Gangliosides and Thermal Adaptation.- Neuronal and Glial Cell Cultures, a Tool for Investigation of Ganglioside Function.- Gangliosides and Synaptic Transmission.- List of Participants.- Contributor Index.
