Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management.
Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.
- Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism
- Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics
- Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism
CHAPTER 1 History of the identification of gigantism and acromegaly CHAPTER 2 Pathology of pituitary growth hormone excess CHAPTER 3 Gigantism: clinical diagnosis and description CHAPTER 4 Acromegaly: clinical description and diagnosis CHAPTER 5 GPR101, an orphan G-protein coupled receptor, with roles in growth, puberty, and possibly appetite regulation CHAPTER 6 The role of the aryl hydrocarbon receptor interacting protein in pituitary tumorigenesis CHAPTER 7 The 3PAs syndrome and succinate dehydrogenase deficiency in pituitary tumors CHAPTER 8 CDKN1B (p27) defects leading to pituitary tumors CHAPTER 9 Multiple endocrine neoplasia syndromes and somatotroph adenomas CHAPTER 10 GNAS, McCune CHAPTER 11 Surgical management of growth hormone-secreting adenomas CHAPTER 12 Medical management of pituitary gigantism and acromegaly CHAPTER 13 GHRH-producing tumors and other neuroendocrine neoplasms associated with acromegaly and/or gigantism CHAPTER 14 Increased growth hormone secretion from lesions outside the anterior pituitary