Regulating virtually all biological processes, the genome's 2,654 newly discovered variants of mature microRNAs - short ribonucleic acid molecules found in eukaryotic cells - hold a key role in the body's toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies.
In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering.
Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence.
- Features chapter contributions from international leaders in the field, covering the spectrum from bench to bedside
- Includes short, applied chapters offering focused discussion and practical examples
- Incorporates multi-color text layout with more than 150 color figures to illustrate important findings
Auflage
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 270 illustrations (200 in full color)
Dateigröße
ISBN-13
978-0-12-820722-2 (9780128207222)
Schweitzer Klassifikation
Part 1: Stem Cells1. MicroRNA Biogenesis in Regenerative Medicine2. Control of Pluripotency and Reprogramming3. Epigenetic Modification of MicroRNAs4. miRNAs in Bone Marrow-Derived Mesenchymal Stem Cells5. miRNAs in Cancer Stem Cells6. MicroRNAs in Neural Stem Cells7. MicroRNAs in Embryonic Stem Cells8. MicroRNAs in Normal and Malignant Myelopoiesis9. MicroRNAs: Molecular Rheostats Regulating Stem Cells Self-renewal and Therapeutic Implications10. MicroRNAs in Endothelial Progenitor Cells
Part 2: Development11. MicroRNA Function in Muscle Homeostasis and Regenerative Medicine12. MicroRNAs in Skin Fibrosis13. MicroRNAs in Hematopoietic Stem Cell Biology14. miRNAs in Bone Formation and Homeostasis15. Lung Development16. MicroRNAs in Pancreas and Islet Development17. MicroRNAs in Skeletal Muscle Differentiation18. MicroRNAs in Brain Development19. MicroRNAs in the Retina and in Visual Connectivity20. MicroRNAs in Neural Crest Development21. Adipogenesis and Obesity
Part 3: Repair22. MicroRNAs with Mega Functions in Cardiac Remodeling and Repair: The Micromanagement of Matters of the Heart23. MicroRNAs in Vascular Remodeling and Repair24. Skin Wound Healing25. miRNAs in Bone Repair26. MicroRNAs as Future Therapeutic Targets for Spinal Cord Injury27. MicroRNA Regulation of Angiogenesis28. Micromanaging Inflammation and Tissue Repair29. MicroRNA Regulation of mTOR Function30. OxymiRs in Regenerative Medicine31. MicroRNAs and Exosomes in Cancer Diagnosis and Therapy32. Organ Transplantation and MicroRNA Expression
Part 4: Regeneration33. MicroRNAs in the Control of Neurogenesis in the Developing Cerebral Cortex34. miRNAs in Transitions: EMT, MET, and EndoMT35. MicroRNAs in Cardiac Regeneration36. MicroRNAs in Liver Regeneration
Part 5: Methodology37. MicroRNA Technology and Small-Molecule Delivery
Part 6: Intervention38. Drug-MicroRNA Cross-Talk39. Delivery and Biological Activity of Therapeutic miRNAs and miRNA Modifiers40. RNA-Based Therapies for Bone Diseases41. MicroRNA-Mediated Regulation of Cardiovascular Differentiation and Therapeutic Implications42. Circulating MicroRNAs as Biomarkers
Part 7: Tissue Engineering43. Nuclear Architecture and Transcriptional Regulation of MicroRNAs44. MicroRNAs in Tissue Engineering and Regenerative Medicine45. microRNAs in Renal Development and Regeneration46. Mitochondrial MicroRNA in Tissue Regeneration47. MicroRNA and Microbiota48. Mitochondrial MicroRNA in Tissue Regeneration49. MicroRNA Detection50. Bone Formation and Homeostasis51. Bone Formation and Homeostasis52. MicroRNAs in Liver Disease53. MicroRNA Bioinformatics54. MicroRNAs in Ischemic Stroke55. MicroRNAs in Senescence56. Ocular miRNA
