Spinal Cord Injury Pain presents the basis for preclinical and clinical investigations, along with strategies for new approaches in the treatment of central neuropathic pain. Contributors from the private sector and academia provide a comprehensive review of state-of-the-art research in this challenging space. Topics include Epidemiology of Chronic Pain Following SCI, experimental models and mechanisms of chronic pain in SCI, and new targets and technologies. This book serves as a resource for continued translational research that will result in novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI.
Despite a better understanding of the complexity of mechanisms of CNP/SCI, improved medical and surgical management of SCI, and the subsequent acceleration of the identification of new targets and the development of novel analgesics, there is still a great unmet clinical need in the area of CNP following SCI. Hence, this book is a welcomed addition to current research and developments.
- Provides a comprehensive resource for novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI
- Includes contributors from the private sector and academia
- Covers epidemiology of chronic pain following SCI, experimental models, mechanisms of chronic pain in SCI, and new targets and technologies
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 100 illustrations (100 in full color)
Dateigröße
ISBN-13
978-0-12-818663-3 (9780128186633)
Schweitzer Klassifikation
Part I: Approaches to the development of new technologies
1. Electrophysiological phenotyping of neuropathic pain following spinal cord injury2. Spinal cord injury pain: A retrospective3. Central neuropathic pain after spinal cord injury: Therapeutic opportunities. A brief history and temporal progression of the pathophysiology from acute trauma to chronic conditions4. Mechanisms of pain below the level of spinal cord injury (SCI)5. Devil's advocate: Why past and future animal models of neuropathic pain in spinal cord injury are without merit6. Counterpoint: Why animal models are indispensable for translational pain research in spinal cord injury7. Behavioral assays of pain in rodent models of spinal cord injury8. Biomarker signatures for neuropathic pain after SCI9. Decoding nociception in the spinal cord: Computer modeling and machine learning10. EEG biomarkers of pain and applications of machine learning11. Perspectives on preclinical evidence for translation in SCI12. Screening and treatment of neuropathic pain after SCI
Part II: Mechanisms of CNP following SCISection 1: Spinal and supraspinal mechanisms13. Spinal GABA mechanism in neuropathic pain after spinal cord injury14. Glial activation and neuropathic pain15. Mechanisms of CNP following SCI: Chemokines in neuronal-glial cell interaction
Section 2: Peripheral mechanisms16. When soft touch hurts: How hugs become painful after spinal cord injury17. Peripheral mechanisms contributing to central neuropathic pain following SCI
Section 3: Clinical applications of novel targets and technologies18. Human neural stem cell transplantation for improved recovery after spinal cord injury19. Cell transplantation for reducing neuropathic pain after SCI20. Gene therapy of neuropathic pain after spinal cord injury21. Exercise as a therapeutic intervention for neuropathic pain after spinal cord injury
