This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as for medical doctors in hepatology.
Damjana Rozman is full Professor of Biochemistry and Molecular Biology at the Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia and Head of the Centre for Functional Genomcis and Bio-Chips (CFGBC).
Rolf Gebhardt is Professor (em.) of Biochemistry at the Rudolf Schönheimer Institute of Biochemistry, Department of General Biochemistry, University of Leipzig, Faculty of Medicine, Leipzig, Germany.
Sterols from the post-lanosterol part of cholesterol synthesis - novel signaling players.- Genetic variability in cholesterol metabolism.- Side-chain oxidized oxysterols in health and disease.- Bile acids and TGR5 (Gpbar1) signaling.- Bile acids as regulatory signalling molecules.- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19.- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.