Epigenome and Developmental Origins of Health and Disease

Epigenome and Developmental Origins of Health and Disease
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 10. Oktober 2015
  • |
  • 560 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-801672-5 (ISBN)
 

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring.

The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring.

It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples.


  • Informs how everyday choices pregnant women make can impact child development
  • Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress)
  • Includes a boxed-in area in each chapter for further references and resources to keep up with the field
  • Features video interviews with the authors and other key leaders in the field
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 9,95 MB
978-0-12-801672-5 (9780128016725)
0128016728 (0128016728)
weitere Ausgaben werden ermittelt
  • Front Cover
  • The Epigenome and Developmental Origins of Health and Disease
  • Copyright
  • Dedication
  • Contents
  • List of Contributors
  • Acknowledgments
  • 1 - The Developmental Origins of Health and Disease (DOHaD) Concept: Past, Present, and Future
  • INTRODUCTION
  • THE ORIGINS OF THE FIELD
  • CONCEPTUAL DEVELOPMENTS AND EXPERIMENTAL OBSERVATIONS
  • DOHAD AND EPIGENETICS
  • THE WIDER DOHAD RESEARCH AGENDA
  • DOHAD AND PUBLIC POLICY
  • References
  • 2 - Historical Perspective of Developmental Origins of Health and Disease in Humans
  • INTRODUCTION
  • SOCIOECONOMIC STRESSORS AND INFANT AND CHILD HEALTH
  • ALLOSTASIS AND ALLOSTATIC LOAD
  • WEATHERING AND AFRICAN AMERICAN HEALTH DISPARITIES
  • ACCULTURATION AND THE HISPANIC PARADOX
  • A LIFE COURSE APPROACH AND THE DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
  • EPIGENETIC REGULATION AND EFFECTS?OF PSYCHOSOCIAL STRESS
  • HEALTH VULNERABILITIES CAN BE HERITABLE
  • CONCLUSIONS
  • References
  • 3 - DOHaD and the Periconceptional Period, a Critical Window in Time
  • INTRODUCTION: DOHAD AND THE?PERICONCEPTIONAL PERSPECTIVE
  • THE PERICONCEPTIONAL PERIOD: A SUMMARY?OF KEY EVENTS
  • IN VIVO MATERNAL NUTRITIONAL MODELS OF PERICONCEPTIONAL PROGRAMMING
  • Maternal Protein Deficiency in Rodents
  • Maternal Undernutrition in Sheep
  • Maternal Overnutrition and Obesity Models
  • IN VITRO MODELS OF PERICONCEPTIONAL PROGRAMMING RELATED TO ASSISTED?REPRODUCTIVE TREATMENTS
  • Culture Medium and Duration
  • Cryopreservation
  • Maternal Age
  • THE PATERNAL INFLUENCE ON PERICONCEPTIONAL DEVELOPMENTAL PROGRAMMING
  • CONCLUSIONS
  • Acknowledgments
  • References
  • 4 - Introduction to Epigenetic Mechanisms: The Probable Common Thread for Various Developmental Origins of Health and Diseases Effects
  • INTRODUCTION
  • DNA METHYLATION
  • POSTTRANSLATIONAL HISTONE MODIFICATIONS
  • NONCODING RNA
  • NUCLEOSOME REMODELING
  • EMBRYONIC EPIGENETIC REPROGRAMMING
  • PRIMORDIAL GERM CELL REPROGRAMMING
  • CONCLUSION
  • References
  • 5 - Perinatal Neurohormonal Programming and Endocrine Disruption
  • INTRODUCTION
  • EFFECTS OF SEX STEROID HORMONES ON BRAIN SEXUAL DIFFERENTIATION
  • SEX STEROID-INDUCED EPIGENETIC REGULATION OF BRAIN SEXUAL DIFFERENTIATION
  • ON BRAIN DEVELOPMENT AND SEXUAL?DIFFERENTIATION
  • ENDOCRINE DISRUPTION OF NORMAL BRAIN PROGRAMMING
  • CONCLUSIONS
  • Glossary
  • References
  • 6 - Parental Nutrition and Developmental Origins of Health and Disease
  • INTRODUCTION
  • OVERNUTRITION
  • UNDERNUTRITION
  • EPIGENETICS AND PRENATAL PROGRAMMING BY MALNUTRITION
  • CONCLUSIONS
  • Acknowledgments
  • References
  • 7 - Maternal Prenatal Stress and the Developmental Origins of Mental Health: The Role of Epigenetics
  • INTRODUCTION
  • Defining the Exposure
  • Effects on the Child
  • Timing of Exposure
  • Underlying Mechanisms
  • EPIGENETICS
  • DNA Methylation
  • Early Life Stress and 5mC
  • Genetic and Gene-by-Environment?Influences on the Epigenome
  • Prenatal Stress and Posttranscriptional Regulation of Gene Expression
  • Transgenerational Effects of Prenatal?Stress
  • Prenatal Stress and Other Regulators of the Epigenome
  • Methodological Considerations
  • CONCLUSIONS
  • References
  • 8 - Epigenetics in the Developmental Origin of Cardiovascular Disorders
  • INTRODUCTION
  • PERIODS OF SUSCEPTIBILITY TO DEVELOPMENTAL PROGRAMMING
  • Periconceptional and Embryonic
  • Fetal and Early Postnatal
  • Adolescence and Adulthood
  • PROGRAMMING STIMULI
  • Diet and Nutritional Factors
  • Xenobiotics and Endocrine Disruptor?Compounds
  • Clinical Conditions
  • Human Studies
  • Animal Studies
  • MECHANISMS OF DOHaD IN CVD
  • General
  • Epigenetic
  • DNA Methylation and?Hydroxymethylation
  • Histone Modifications
  • RNA Mechanisms
  • CONCLUDING REMARKS
  • Acknowledgments
  • References
  • 9 - Developmental Effects of Endocrine-Disrupting Chemicals in the Ovary and on Female Fertility
  • INTRODUCTION
  • OVARIAN DEVELOPMENT AND FUNCTION
  • Primordial Germ Cells and Gonadal Differentiation
  • Oocyte Nest Breakdown and Primordial Follicle Formation and Primordial-to-Primary Follicular Transition
  • Preantral and Antral Follicle Growth and Follicular Recruitment, Selection, and Maturation or Atresia
  • Ovulation and Corpus Luteum Formation
  • Endocrine-disrupting Chemicals Can Affect?the Ovary Several Ways
  • Reproductive Senescence
  • EFFECTS OF ENDOCRINE-DISRUPTING CHEMICALS ON FEMALE REPRODUCTION AND OVARY
  • Phthalates
  • Phthalates-Epidemiological Studies
  • Phthalates-Animal Studies
  • Organochlorine Pesticides
  • DDT and Its Metabolites
  • DDT-EPIDEMIOLOGICAL STUDIES
  • DDT-ANIMAL STUDIES
  • Methoxychlor
  • MXC-EPIDEMIOLOGICAL STUDIES
  • MXC-ANIMAL STUDIES
  • Dioxins
  • Dioxin-Epidemiological Studies
  • Dioxin-Animal Studies
  • Diethylstilbestrol
  • DES-Epidemiological Studies
  • DES-Animal Studies
  • CONCLUSIONS
  • Acknowledgments
  • References
  • 10 - Developmental and Epigenetic Origins of Male Reproductive Pathologies
  • INTRODUCTION
  • ENVIRONMENTAL FACTORS KNOWN TO CORRELATE?WITH MALE REPRODUCTIVE DYSFUNCTION
  • DEVELOPMENTAL ENVIRONMENT AND ESTABLISHMENT OF EPIGENETIC PATTERNS
  • DEVELOPMENTAL EXPOSURES AND THE INCIDENCE?OF MALE REPRODUCTIVE ABNORMALITIES
  • ENVIRONMENTALLY INDUCED TRANSGENERATIONAL EPIGENETIC EFFECTS RELATED TO MALE REPRODUCTION
  • GERM LINE TO SOMATIC EPIGENETIC EFFECTS:?LESSON FROM THE VINCLOZOLIN TRANSGENERATIONAL?MODEL
  • EPIGENETIC MARKS IN FERTILITY: DNA METHYLATION AND HISTONE MODIFICATIONS
  • EPIGENETIC MARKS AND FERTILITY: SMALL?NONCODING RNAS
  • CONCLUSIONS AND PERSPECTIVES
  • Acknowledgments
  • References
  • 11 - Developmental Origins of Childhood Asthma and Allergic Conditions-Is There Evidence of Epigenetic Regulation?
  • INTRODUCTION
  • What Does the Epidemiology Tell Us?
  • What are the Developmental Origins of Asthma and Eczema?
  • What Factors are Associated with Asthma and Eczema?
  • What Do Intervention Studies Tell Us?
  • Asthma and Eczema on the Context of Other Noncommunicable Diseases
  • Fetal Origins of Disease
  • Antenatal Fetal Measurements and Asthma Outcomes
  • Antenatal Fetal Measurements and Eczema Outcomes
  • Factors Associated with Altered Fetal Size
  • Postnatal Weight Gain
  • So How Does Epigenetics Fit into the Development of Asthma and Eczema?
  • Epigenetic Mechanisms
  • Associations between Asthma, Eczema, and Epigenetic Variation
  • Associations between Antenatal and Postnatal Environmental Exposures and Epigenetic Variation
  • CONCLUSIONS
  • References
  • 12 - Immune Disorders, Epigenetics, and the Developmental Origins of Health and Disease
  • INTRODUCTION
  • ENVIRONMENTAL RISK FACTORS AFFECTING?IMMUNE FUNCTION AND INDIVIDUAL?VULNERABILITY
  • THE IMMUNE SYSTEM, DEVELOPMENTAL?ORIGINS OF ADULT HEALTH AND DISEASE,?AND PUBLIC HEALTH IMPLICATIONS
  • IMMUNE PROGRAMMING BY THE MICROBIOTA
  • INTERLINKAGE OF IMMUNE DISORDERS
  • Co-occurrence of Immunosuppression and Inappropriate Immune Enhancement
  • IMMUNE DISORDERS AND COMMUNICABLE?DISEASES
  • IMMUNE DISORDERS AND NONCOMMUNICABLE DISEASES
  • Allergic Disorders
  • Allergic Rhinitis
  • Atopic Dermatitis
  • Asthma
  • Food Allergies
  • AUTOIMMUNE DISORDERS
  • Celiac Disease
  • Multiple Sclerosis
  • Systemic Lupus Erythematosus
  • Female Prevalence in SLE
  • Infectious Agents in Systemic Lupus Erythematosus
  • Epigenetics in Systemic Lupus?Erythematosus
  • Type 1 Diabetes
  • INFLAMMATORY DISORDERS
  • Atherosclerosis
  • Depression
  • Psoriasis
  • Sleep Disorders
  • CONCLUSIONS
  • References
  • 13 - Neurobehavioral Disorders and Developmental Origins of Health and Disease
  • INTRODUCTION
  • THE RISK ASSOCIATED WITH EARLY-LIFE INSULTS
  • CHANGES IN THE STRESS SYSTEM DURING?PREGNANCY
  • ORGANOGENESIS
  • TIMING OF INTRAUTERINE EXPOSURES
  • EMOTIONAL REGULATION
  • Birth Phenotype
  • Length of Gestation
  • Birth Weight
  • Intrauterine Exposures
  • Fetal Exposure to Maternal Psychological?Distress
  • Fetal Exposure to Maternal HPA Axis?and Placental Hormones
  • COGNITIVE REGULATION
  • Birth Phenotype
  • Length of Gestation
  • Birth Weight
  • Intrauterine Exposures
  • Fetal Exposure to Maternal?Psychological Distress
  • Fetal Exposure to the Maternal?HPA Axis
  • EPIDEMIOLOGICAL EVIDENCE FOR PROGRAMMING NEUROBEHAVIORAL OUTCOMES
  • Birth Phenotype: Neurodevelopmental?and Clinical Outcomes
  • Intrauterine Effects: Neurodevelopmental?and Clinical Outcomes
  • PROGRAMMING THE VULNERABLE HUMAN?FETAL BRAIN
  • BIRTH PHENOTYPE AND NEURONAL?CONSEQUENCES
  • Length of Gestation
  • Birth Weight/Size
  • NEURONAL CONSEQUENCES OF INTRAUTERINE?EXPOSURES
  • Exposure to Early-Life Stress
  • Fetal Exposure to Maternal Psychological?Distress
  • Fetal Exposure to the Maternal HPA Axis
  • SEX DIFFERENCES AND THE DOHAD MODEL
  • CONCLUSIONS
  • Acknowledgments
  • References
  • 14 - Metabolic Disorders and Developmental Origins of Health and Disease
  • INTRODUCTION
  • INTRAUTERINE GROWTH RESTRICTION
  • IUGR Induced by Maternal Dietary Protein Restriction
  • Uteroplacental Insufficiency Model of IUGR
  • IUGR Induced by Maternal Total Calorie Restriction
  • GESTATIONAL DIABETES IN PREGNANCY?AND METABOLIC PROGRAMMING OF?THE OFFSPRING
  • Population-Based Studies Examining the?Effect of Diabetes in Pregnancy on the Offspring
  • Oxidative Stress: A Possible Link Between?Diabetes in Pregnancy and Chromatin Remodeling in the Offspring
  • Evidence of Epigenetic Programming?of Gene Expression in Humans?Exposed to GDM
  • OBESITY IN PREGNANCY AND METABOLIC PROGRAMMING OF THE OFFSPRING
  • Stages of the Developing Adipocyte: Determination and Differentiation
  • Experimental Systems for Studying?Adipogenesis
  • Adipogenesis
  • CAAT/Enhancer Binding Proteins
  • PPAR? - A Master Regulator of Adipogenesis
  • Epigenetic Regulation of Adipogenesis
  • Epigenetic Regulation of Preadipocyte Determination
  • Chromatin Remodeling and C/EBP Transcription Factors in Adipogenesis
  • Epigenetic Regulation of PPAR?:?The Role of Histone Acetylation
  • Histone Methylation in Adipogenesis
  • Linking In Utero Exposures to?the Development of Obesity in?the Offspring
  • CONCLUSION
  • References
  • 15 - The Developmental Origins of Renal Dysfunction
  • INTRODUCTION
  • IMPACT OF THE PRENATAL ENVIRONMENT ON RENAL DYSFUNCTION AND CHRONIC KIDNEY DISEASE
  • KIDNEY DEVELOPMENT AND NEPHRON?ENDOWMENT
  • THE IMPORTANCE OF NEPHRON ENDOWMENT:?LINKS TO BLOOD PRESSURE AND RENAL DISEASE
  • EXPLORING THE MECHANISMS OF RENAL PROGRAMMING OF LOW NEPHRON ENDOWMENT: EVIDENCE FROM ANIMAL MODELS
  • Maternal Nutrition
  • Maternal Hypoxia and Uteroplacental?Insufficiency
  • Maternal Glucocorticoid Exposure
  • Maternal Substance Exposure during?Pregnancy
  • WHY IS THE KIDNEY SUSCEPTIBLE TO?PROGRAMMING?
  • MECHANISMS LEADING TO IMPAIRED RENAL STRUCTURE AND FUNCTION
  • Mechanisms Contributing to Altered Renal Development
  • Mechanisms Contributing to Long-term?Alterations in Renal Function
  • Renal Tubules and Sodium Channels
  • Renin-Angiotensin System
  • Epigenetic and Transgenerational Regulation?of Renal Function
  • CONCLUSIONS
  • References
  • 16 - Cancer and Developmental Origins of Health and Disease-Epigenetic Reprogramming as a Mediator
  • INTRODUCTION
  • EPIGENETIC REGULATION IN CANCER
  • DEVELOPMENTAL ORIGIN OF ADULT DISEASE
  • DEVELOPMENTAL ORIGIN OF ADULT DISEASE?AND BREAST CANCER
  • DEVELOPMENTAL ORIGIN OF ADULT DISEASE AND PROSTATE CANCER
  • OTHER CANCERS
  • EPIGENETICALLY ACTIVE AGENTS INVOLVED IN CARCINOGENESIS
  • EXOGENOUS FACTORS
  • Heavy Metals
  • Endocrine-Disrupting Chemicals
  • Xenoestrogens
  • Pesticides and Insecticides
  • Agent Orange
  • Light
  • ENDOGENOUS FACTORS
  • Oxidants
  • Vitamins
  • Endogenous Hormones
  • Fatty Acids and Glucose
  • CONCLUSIONS
  • Glossary Terms, Acronyms,?and Abbreviations
  • Acknowledgments
  • References
  • 17 - Epigenetic Regulation of Gastrointestinal Epithelial Barrier and Developmental Origins of Health and Disease
  • INTRODUCTION
  • EPIGENETICS AND GI TRACT DEVELOPMENT?AND MATURATION
  • THE GUT MICROBIOTA AND PROGRAMMING
  • The Gut Microbiota and Associated Metabolic Activities
  • The Gut Microbiota and Epigenetic Processes
  • The Gut Microbiota as a Long-term Memory?of Perinatal Life
  • The Particular Role of Butyrate in Epigenetic Modulation of GI Epithelium
  • DEVELOPMENTAL ORIGINS OF GI DISEASES
  • Inflammatory Bowel Disease
  • Epidemiology
  • Animal Studies
  • Irritable Bowel Syndrome
  • Epidemiology
  • Environmental Factors and Epigenetics?in IBS
  • Animal Studies
  • Generational Transfer and Epigenetics
  • Colorectal Cancer
  • Epidemiological Studies
  • Animal Studies
  • FOOD AND EPIGENETICS OF THE GI EPITHELIUM
  • Methyl Donors and Precursors
  • Dietary Modulators/Inhibitors of Epigenetic Enzymes
  • HDAC Inhibitors from Cruciferous Vegetables
  • Allyl Compounds from Garlic
  • Dietary Polyphenols
  • Dietary Isoflavones
  • Other Food Compounds and Interactions
  • CONCLUSIONS AND FUTURE DIRECTIONS
  • ABBREVIATIONS
  • References
  • 18 - How the Father Might Epigenetically Program the Risk for Developmental Origins of Health and Disease Effects in His Offspring
  • INTRODUCTION
  • SPERM EPIGENETICS
  • DNA Methylation
  • Histone Modifications, Variants,?and Protamines
  • mRNA, Proteins, and Small?Noncoding RNA
  • ZYGOTIC EPIGENETIC REPROGRAMMING
  • PATERNAL AGING
  • PATERNALLY DRIVEN ENVIRONMENTAL EFFECTS
  • TRANSGENERATIONAL EPIGENETIC INHERITANCE
  • CONCLUSIONS
  • References
  • 19 - Linkage between In Utero Environmental Changes and Preterm Birth
  • INTRODUCTION
  • ENVIRONMENTAL EXPOSURES
  • CHEMICALS
  • Metals
  • Polycyclic Aromatic Hydrocarbons
  • Endocrine Disrupters
  • PARTICLES/AIR POLLUTION
  • Industrial and Combustion Engine?Air Pollution
  • Tobacco Smoke
  • MATERNAL HEALTH
  • Obesity
  • Diabetes
  • Nutrition
  • CONCLUSIONS
  • Glossary Terms
  • References
  • 20 - Sexual Dimorphism and DOHaD through the Lens of Epigenetics: Genetic, Ancestral, Developmental, and Environmental Origins from Previous to the Next Generation(s)
  • INTRODUCTION
  • COMPLEX TRAJECTORIES DUE TO SEX SPECIFICITY TO BOTH THE TRANSMISSION AND INHERITANCE OF SUSCEPTIBILITY
  • Sexual Dimorphism and Nongenetic?Heritability
  • Resilience-a Neglected Approach
  • Transgenerational Responses to Programming:?A Vicious Circle or Resilience?
  • MECHANISMS OF UNEQUAL EXPRESSION OF X-?AND Y-CHROMOSOME-LINKED GENES
  • Early Involvement of Sex Chromosomes in?Sex Differences
  • Sex Differences: Sex Hormones and/or Sex Chromosomes?
  • Unequal Dosage and Compensation?Mechanisms between Males (XY) and?Females (XX)
  • Male-Specific Y Chromosome Genes
  • EPIGENETICS AND GENE EXPRESSION: SEX-?SPECIFIC MARKS, MECHANISMS, AND DYNAMICS
  • Sex-Specific Epigenetic Marks Modulate Sex-Specific Gene Expression
  • Sex-Specific Impact of Environmental?Influences
  • The Special Case of X/Y Pairs of Paralogues
  • THE SPECIFIC EPIGENETIC FEATURES OF EXTRAEMBRYONIC TISSUES AND PLACENTA
  • The Specific Features of the Placenta
  • Sex Differences: Sex Hormones and/or Sex Chromosomes?
  • DIFFERENCES BETWEEN MALE/FEMALE?GAMETOGENESIS
  • Even before Conception for the Future?Father and the Mother
  • DIFFERENCES IN REPROGRAMMING OF MATERNAL/PATERNAL GENOME
  • Environmental and Metabolic Programming?from Fertilization to Preimplantation
  • The Various Phases of Reprogramming and the?Twists of Mark Erasure
  • Mysterious Intermediaries Passing on the?Message from Generation to Generation
  • Noncoding RNAs
  • Skip in Generation
  • Persistence?
  • WHAT LEVELS OF EVIDENCE: THE LIMITING AND CONFOUNDERS FACTORS
  • CONCLUSIONS
  • References
  • 21 - Transgenerational Epigenetic Inheritance: Past Exposures, Future Diseases
  • INTRODUCTION
  • A CRUCIAL ROLE FOR THE GERMLINE IN EPIGENETIC AND GENETIC INHERITANCE
  • EVIDENCE FOR TRANSGENERATIONAL EPIGENETIC INHERITANCE IN ANIMAL MODELS
  • Initial Studies
  • Exposure to Other Environmental Toxicants?and Drugs
  • Dietary Exposures and Exercise
  • Behavioral Effects
  • Fish and Invertebrates
  • EVIDENCE FOR TRANSGENERATIONAL EPIGENETIC INHERITANCE IN HUMANS
  • ENVIRONMENTAL EXPOSURES AFFECTING?THE MALE GERMLINE: ADULT VERSUS?DEVELOPMENTAL EXPOSURES
  • CONCLUSIONS AND PERSPECTIVES
  • Acknowledgments
  • References
  • 22 - The Placenta and Developmental Origins of Health and Disease
  • INTRODUCTION
  • EPIDEMIOLOGY AND THE PLACENTA
  • PLACENTAL FUNCTION
  • The Placental Barrier
  • Placental Drug Transfer
  • Placental Nutrient Transfer
  • ENVIRONMENTAL INFLUENCES ON PLACENTAL?FUNCTION
  • Maternal and Fetal Signals
  • Maternal Body Composition
  • Maternal Diet
  • Uteroplacental and Umbilical Blood Supply
  • Maternal Exercise
  • Maternal Stress and Glucocorticoids
  • Environmental Toxins
  • EPIGENETICS AND THE PLACENTA
  • The Placental Epigenome
  • Environmental Influences on Placental Epigenetics
  • Placental Epigenetic Influences on the Fetus
  • Placental Imprinting
  • Placental Influences on Fetal Epigenetics
  • THE "PLACENTAL PHENOTYPE," INTERVENTIONS,?AND TREATMENTS
  • Interventions
  • CONCLUDING REMARKS AND FUTURE DIRECTIONS
  • References
  • 23 - The Moral and Legal Relevance of DOHaD Effects for Pregnant Mothers
  • INTRODUCTION: DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE RESEARCH AND LEGISLATIVE INTERVENTIONS
  • THE LEGAL RECOGNITION OF FETAL RIGHTS
  • THE CRIMINALIZATION OF THE "BAD MOTHER"
  • CARING FOR FETUSES VERSUS CARING FOR FUTURE PERSONS
  • BENEFICENCE, NONMALEFICENCE, AND FUTURE?PEOPLE
  • The Magic Doll Analogy
  • DOHAD EFFECTS ARE NOT DETERMINISTIC
  • DOHAD AND THE NONIDENTITY PROBLEM
  • DO WOMEN HAVE A DUTY TO ABORT IN ORDER?TO AVOID CAUSING DEVELOPMENTAL ORIGINS OF?HEALTH AND DISEASE HARM TO FUTURE?PERSONS?
  • IS THE CRIMINALIZATION OF MOTHERS?JUSTIFIABLE?
  • CONCLUSIONS
  • Endnotes
  • References
  • Bibliography
  • 24 - Introduction to Moms in Motion (MIM)
  • ABBREVIATIONS
  • References
  • 25 - Reversing Harmful Developmental Origins of Health and Disease Effects
  • INTRODUCTION
  • Community Partners' Perspectives Working?with Academic Researchers
  • WIC Perspectives
  • Suggested Strategies for Working with Community Partners Such as WIC
  • Factors Affecting WIC Involvement
  • Researchers' Reflections on Successfully Working with WIC
  • Primary Aim and Hypotheses
  • Prior Studies
  • Focus Group Discussions with?Overweight and Obese WIC Mothers
  • METHOD
  • RESULTS
  • Pilot Mothers in Motion
  • METHOD
  • RESULTS
  • METHOD
  • Overview of the Ongoing Mothers In Motion?Program
  • Community and Peer Advisory Groups
  • The Conceptual Model
  • Intervention
  • Culturally Sensitive DVDs
  • TRAINING OF WIC (FEATURED) MOTHERS IN THE DVDS
  • THE DVD CHAPTERS
  • DVD COMPONENTS
  • DVD REVIEW
  • DVD CHAPTERS WATCHED AT HOME
  • Peer Support Group Teleconference
  • TRAINING OF MODERATORS
  • PSGTS DIAL IN AT ANY CONVENIENT LOCATION
  • Comparison Group
  • Setting, Participants, and Recruitment
  • Recruiter Training and Recruitment Strategies
  • Sequential Screening
  • Recruitment Challenges and?Modification
  • Randomization
  • Retention Strategies
  • Measurements
  • Primary Outcome
  • Additional Mediators
  • Sample Size and Statistical?Methods
  • DISCUSSION
  • Limitations
  • Conclusions
  • Future Studies
  • ABBREVIATIONS
  • References
  • 26 - Informational Resources for Developmental Origins of Health and Disease Research
  • INTRODUCTION
  • DOHAD-RELATED SCIENTIFIC?ORGANIZATIONS
  • DOHAD-RELATED SCIENTIFIC MEETINGS
  • DOHAD-RELATED JOURNALS, DATABASES,?AND OTHER INFORMATIVE RESOURCES
  • SOCIAL MEDIA RESOURCES REPORTING?DEVELOPMENTAL ORIGINS OF HEALTH?AND DISEASE FINDINGS
  • JUDGING THE RELIABILITY OF DEVELOPMENTAL?ORIGINS OF HEALTH AND DISEASE INFORMATIONAL?RESOURCES
  • CONCLUSIONS
  • Glossary
  • Acknowledgments
  • References
  • Example DOHaD-Related Scientific Meetings
  • Journals and Databases to Find DOHaD Articles
  • Social Media Resources for DOHaD Topics
  • Example DOHaD YouTube Videos
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z
  • Back Cover

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