The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses.
With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.
Chapter 1. The Natural History of Breast CancerChapter 2. Perioperative Inflammation as Triggering Origin of Metastasis Development Chapter 3. Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer PatientsChapter 4. Perioperative Biologic Perturbation and Cancer Surgery: Targeting the adrenergic-inflammatory response and microcirculatory dysregulationChapter 5. Circulating tumor cells as predictive marker in metastatic diseaseChapter 6. Randomized Clinical Trials on Breast Cancer in Nigeria and other Developing Countries- Challenges and ConstraintsChapter 7. Do Breast Cancer Patients Benefit from Surgery? Hypotheses, Mathematical Models and False Beliefs Chapter 8. The impact of wound inflammation on cancer progression; Studies in fish and patientsChapter 9. Long term consequences of acute inflammation in cancer surgery: New findings and perspectivesChapter 10. Cancer: Nurture and NatureChapter 11. The systemic effects of local treatments (surgery and radiotherapy) of breast cancer
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