Advances in Pathobiology and Management of Paget's Disease of Bone

 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 28. April 2016
  • |
  • 158 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
978-0-12-809690-1 (ISBN)
 

Advances in Pathobiology and Management of Paget's Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget's disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as osteosarcoma, and current and future treatment for Paget's disease. This book serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease.


  • Discusses the current research of the nature of Paget's disease and its response to the latest treatments which are seminal in the management of this disease
  • Helps users quickly assess the very latest details on the diverse scientific and clinical aspects of Paget's disease, as opposed to searching through multiple journal articles in the literature
  • Presents work from featured leaders in Paget's disease around the globe
  • Serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 3,12 MB
978-0-12-809690-1 (9780128096901)
012809690X (012809690X)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Advances in Pathobiology and Management of Paget's Disease of Bone
  • Copyright Page
  • Contents
  • List of Contributors
  • About the Editor
  • Preface
  • 1 Clinical Perspectives of Paget's Disease of Bone
  • Introduction
  • Natural History
  • Clinical Features and Complications
  • Diagnosis
  • Pathology
  • Biochemistry
  • Epidemiology
  • Secular Change in Paget's Disease
  • References
  • 2 Viral Etiology of Paget's Disease of Bone
  • Introduction
  • Paramyxo-Viral Etiology
  • Viral and Genetic Interactions
  • Acknowledgments
  • References
  • 3 Genetics of Paget's Disease of Bone
  • Introduction
  • Importance of Genetic Factors
  • SQSTM1
  • TNFRSF11B
  • VCP
  • Chromosome 1p13 Locus
  • Chromosome 7q33
  • Chromosome 8q24
  • Chromosome 10p13
  • Chromosome 14q32
  • Chromosome 15q24
  • Chromosome 18q21
  • Genetic Determinants of Disease Severity
  • Clinical Implications
  • References
  • 4 Developmental Aspects of Pagetic Osteoclasts
  • Introduction
  • Increased Sensitivity of OCL Progenitors to Osteotropic Factors
  • Increased Sensitivity to RANKL and TNFa
  • Increased Sensitivity to 1,25-(OH)2D3
  • Increased Nuclei/OCL
  • Increased Expression of IL-6
  • MVNP Activation of TBK1 Increases IL-6, OCL Formation, and Nuclei/OCL
  • MVNP Downregulation of FoxO3 and Sirt1 also Increase IL-6
  • Increased Irregular Woven Bone Formation Induced by Pagetic OCL
  • EphrinB2/EphB4 Signaling
  • IGF1, FGF2, and CXCL5
  • Conclusion
  • Disclosures
  • References
  • 5 Mutant SQSTM1/p62 Signaling in Paget's Disease of Bone
  • Introduction
  • RANKL-Induced NF?B Signaling and Osteoclastogenesis
  • Defective NF?B Signaling Associated With Mutant SQSTM1/p62
  • SQSTM1/p62-Mediated RANKL-Induced AP-1, NFAT, and ERK Signaling
  • SQSTM1/p62-Mediated Regulation of Keap1/Nrf2 Signaling
  • SQSTM1/p62-Mediated Apoptosis
  • SQSTM1/p62-Mediated Autophagy
  • SQSTM1/p62 as a Signaling Hub Orchestrating the Interplay Between NF?B, Keap1 and Autophagy
  • References
  • 6 Early Onset Pagetic Disorders: Implications for Late-Onset Paget's Disease of Bone
  • Introduction
  • Early-Onset Pagetic Syndromes
  • RANK
  • Juvenile Paget's Disease
  • Osteoprotegerin
  • Multisystem Proteinopathy
  • Valosin-containing protein
  • Molecular Mechanisms Leading to Early-Onset Pagetic Disorders and Relevance for Late-onset PDB
  • Classic PDB: Association With Genes Involved in RANK Signaling and/or Osteoclast Formation
  • Classic PDB: Genes Involved in Protein Degradation Pathways
  • PDB: A Disorder of Protein Conformation?
  • Acknowledgments
  • References
  • 7 Osteosarcoma in Paget's Disease of Bone
  • Introduction
  • Epidemiology
  • Clinical Presentation
  • Histopathology
  • Treatment and Prognosis
  • The Progression From Normal Bone to Paget's Disease to Pagetic Osteosarcoma
  • Genes Differentially Expressed in Paget's Disease and Pagetic Osteosarcoma
  • Acknowledgments
  • References
  • 8 Paget's Disease of Bone: Prognosis and Complications
  • Introduction
  • Prognosis of Paget's Disease of Bone
  • Morbidity and Quality of Life
  • Mortality
  • Impact of Pharmacological Treatment of PDB on the Prognosis
  • Bone Complications
  • Secondary Osteoarthritis
  • Neoplastic Degeneration
  • Neurological Complications
  • Cardiovascular Complications
  • Other Complications
  • Disclosures
  • References
  • 9 Treatment of Paget's Disease of Bone
  • Introduction
  • Antipagetic Medications
  • Calcitonin
  • Bisphosphonates
  • Safety of Bisphosphonates
  • Future Medicines
  • Whom to Treat
  • Monitoring
  • Analgesics
  • Surgery
  • Disclosure
  • References
  • Index
  • Back Cover

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