This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases.
Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.
Dr. Gerard Marshall Raj. D holds an M.B.B.S. and M.D. in Pharmacology. Currently, he is working as an Assistant Professor at the Dept. of Pharmacology, Sri Venkateshwaraa Medical College Hospital & Research Centre, Puducherry, India. He has published two book chapters, one on 'Intellectual Property Rights in Drug Development and Biotechnology' in the book 'Intellectual Property Issues in Biotechnology' (CABI; ISBN: 9781780646534) and the other on 'Intellectual Property Issues Surrounding Antimicrobial Agents' in the book 'Intellectual Property Issues in Microbiology' (Springer-Nature; ISBN: 9789811374654). He was awarded the 'Prof. M. N. Ghosh Gold Medal' for outstanding performance during the M.D. Pharmacology course at JIPMER, Puducherry and has published many research articles, reviews, commentaries, case reports and letters-to-the-editor in peer-reviewed and indexed journals.
Dr. Ramasamy Raveendran, Dean (Research) -cum- Professor (Senior Scale) and Head of Pharmacology, JIPMER, Puducherry, graduated from the University of Madras and obtained his M.D. degree in Pharmacology from JIPMER, Puducherry and his Diploma in Clinical Pharmacology from St Bartholomew's Medical College, London, UK. With over 34 years of research and teaching experience, his main interests include Computer Assisted Learning (CAL) and toxicology. He has authored 55 research papers, 7 CAL software packages and 1 book. He has also conducted more than 50 workshops on research methodologies, biomedical communication and biostatistics throughout India. He was chief editor of the Indian Journal of Pharmacology from 2001 to 2006 and is currently editor-in-chief of the Journal of Pharmacology and Pharmacotherapeutics (since 2010). Further, as the Dean (Research) of JIPMER, he is coordinating all research activities at the premier institute.
General pharmacological principles and allied sciences1. Historical aspects of drug discovery 1) Landmarks in the growth and development of pharmacology2) Wonder discoveries in pharmacologyi. Nobel laureates in pharmacology and their revolutionary discoveries ii. Important contributions of renowned Indian pharmacologists
2. General pharmacological principles 1) Source, nature and preparations of drugs 2) Principles and modes of drug administrationi. Dosage forms & drug delivery systems3) Pharmacokinetic principles and parameters i. Absorptionii. Distributioniii. Metabolism (Biotransformation)1. Drug metabolizing enzymesiv. Elimination4) Theories and mechanism of drug action (Pharmacodynamics) i. Physiological and biochemical basis of drug action1. Molecular targets of drug action ii. Drug receptors and pharmacodynamicsiii. Dose response relationships 1. Concentration-response relationshipsiv. Factors modifying drug action (response) 5) Drug transporters 6) Adverse effects of drugs i. Pharmacovigilance & ADR monitoring1. Hemovigilance2. Materiovigilance3. Cosmetovigilance4. Addictovigilance7) Drug interactions i. Synergismii. Antagonismiii. Adverse drug interactions8) Structure-activity relationships i. Steroids ii. Antihistaminesiii. Catecholamines iv. Opioidsv. Antipsychotics
3. Special topics in pharmacology 1) Drug information and sources of drug information i. Use of information technology2) Pharmacogenetics, Pharmacogenomics and Personalized medicine 3) Chronopharmacology 4) Pharmacoepidemiology i. Drug utilization studies ii. Therapeutic audit5) Ethnopharmacology i. Role of medicinal plantsii. Isolation of compounds from herbal sources6) Pharmacoeconomics 7) Orphan drugs & diseases 8) Fixed dose combinations 9) Translational medicine i. Reverse pharmacology10) Gene therapy 11) Stem cell therapy 12) Principles of prescription writing i. Over the counter drugs1. Therapeutic & Toxic Potential
4. Toxicology 1) Environmental, Occupational and Industrial Toxicology i. Environmental - heavy metal1. Arsenic2. Mercury3. Lead4. Cadmiumii. Nonmetallic environmental toxicants 1. Air pollutants2. Insecticides3. Rodenticides4. Fungicides5. Herbicides6. Fumigants
2) Basic principles of diagnosis and treatment of drug poisoning i. Clinical features of common poisoningii. Applied analytical toxicologyiii. Antidotes in the management of poisoning 1. Heavy Metal Intoxication and Chelatorsiv. Toxicovigilance
5. Molecular Biology in Pharmacology 1) Gene expression2) Proteomics3) Techniques involved in studying receptor dynamics4) PCR5) Northern blot, Southern blot and Western blot 6) Protein purification 7) Molecular biology in receptor identification 8) Antisense oligonucleotides 9) Recombinant DNA technology