This book combines the current knowledge on the role of lipids in stem cell pluripotency and differentiation. It showcases various approaches to the study of lipids and focuses on various types of stem cells and specific lipids driving maintenance or differentiation. The volume includes chapters reviewing roles of specific lipids in pluripotency, neurogenesis and exocytosis as well as in cancer stem cells. Examples of different classes of lipids-such as sphingolipids, lysophospholipids, cannabinoids and neutral lipids-are described and illustrate the vast biological effects of this class of molecules. The international contributors are all recognized experts in their respective fields.
Covering the various aspects of the topic, Lipidomics of Stem Cells provides an up-to-date snapshot-unique among the literature-of where the lipid world is in terms of understanding the roles of lipids in stem cell biology. It provides an essential reference for stem cell biologists, lipid biologists, development biologists, students, academics and clinicians in related areas.
Associate Professor Alice Pébay, Ph.D., is a Principal Research Fellow at the University of Melbourne and the principal investigator of the Neuroregeneration Unit at the Centre for Eye Research Australia. She holds a Ph.D. in neuroscience and has extensive expertise in cell biology, having published more than 50 peer reviewed articles and chapters in the field of stem cell biology and lysophospholipid biology. Dr Pébay's current research focuses on the mechanisms that enable human pluripotent stem cells to maintain their pluripotency and allow them differentiate towards specific retinal lineages. Dr Pébay also has comprehensive experience in neurotrauma research and a strong interest in the cellular mechanisms involved in the genetic disease, Friedreich Ataxia.
Dr. Raymond CB Wong, Ph.D., is a Senior Research Fellow at the University of Melbourne and the principal investigator of the Cellular Reprogramming Unit at the Centre for Eye Research Australia. He is a stem cell biologist specialising in human pluripotent stem cells and reprogramming. He completed his Ph.D. in stem cell biology (Monash University) and overseas postdoctoral training in University of California Irvine and subsequently National Institutes of Health. His previous research in the past 13 years has led to improvement in methods of growing and generating human pluripotent stem cells. Dr. Wong's current research focuses on developing methods to turn human pluripotent stem cells into retinal cells, as well as utilizing human stem cells to model and study pathological progression of various retinal diseases to improve treatment options.
Preface.- 1. Lysophosphatidic Acid and Sphingosine-1-Phosphate in Pluripotent Stem Cells.- 2. Morphogenetic Sphingolipids in Stem Cell Differentiation and Embryo Development.- 3. Autotaxin in Stem Cell Biology and Neurodevelopment.- 4. Lysophosphatidic Acid (LPA) Signaling in Neurogenesis.- 5. Fate Through Fat: Neutral Lipids as Regulators of Neural Stem Cells.- 6. Cannabinoids as Regulators of Neuronal Development and Adult Neurogenesis.- 7. Ceramide-1 Phosphate and Its Role in Trafficking of Normal Stem Cells and Cancer Metastasis.- 8. The Emerging Role of Sphingolipids in Cancer Stem Cell Biology.- 9. Lysophosphatidic Acid Signalling Enhances Glioma Stem Cell Properties.- 10. New Developments in Free Fatty Acids and Lysophospholipids: Decoding the Role of Phospholipases in Exocytosis.- Index.