Cardiovascular Diseases

Genetic Susceptibility, Environmental Factors and their Interaction
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 5. August 2016
  • |
  • 252 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-803313-5 (ISBN)
 

Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction covers the special heritability characteristics and identifying genetic and environmental contributions to cardiovascular health. This important reference provides an overview of the genetic basis of cardiovascular disease and its risk factors.

Included are important topics, ranging from lifestyle choices, risk factors, and exposure, to pollutants and chemicals. Also covered are the influences of Mendelian traits and familial aggregation and the interactions and interrelationships between genetics and environmental factors which, when compared, provide a sound understanding of the interplay between inherited and acquired risk factors.

The book provides a much needed reference for this rapidly growing field of study. By combining the latest research within the structured chapters of this reference, a better understanding of genetic and environmental contribution to cardiovascular disease is found, helping to substantiate further investigations in the field and design prevention and treatment strategies.

  • Provides an overview of the genetic basis of cardiovascular disease and its risk factors
  • Reviews several large population-based studies which indicate that exposure to several environmental factors may increase CVD morbidity and mortality, exploring the plausibility of this association by data from animal studies
  • Reflects on future studies to help understanding the role of genes and environmental factors in the development and progression of cardiovascular disease


Dr. Papageorgiou has completed his basic training in Greece and continued his cardiology training in Dusseldorf, Germany and thereafter in London, UK. He has trained at the London Heart Hospital, University College London and currently at the Barts Heart Centre, St. Bartholomew's Hospital London UK. He has a strong interest in endothelial function and the mechanisms of atherosclerosis. He also has a strong interest in the role of genetics in cardiovascular disease and holds a PhD degree which is related to that. Currently, he focuses on arrhythmias and the therapeutic approaches which aim to them. He is a reviewer of several international journals, member of the EACVI35. Dr. Papageorgiou currently has over 120 publications in peer reviewed journals, all PubMed listed, and has done more than 100 presentations in international conferences where he has been an invited speaker.
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 3,52 MB
978-0-12-803313-5 (9780128033135)
0128033134 (0128033134)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Cardiovascular Diseases
  • Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and their Interaction
  • Copyright
  • Dedication
  • Contents
  • List of Contributors
  • Acknowledgments
  • 1 - Summary
  • 2 - Atherosclerosis and Coronary Artery Disease: From Basics to Genetics
  • INTRODUCTION
  • NORMAL ARTERY STRUCTURES
  • PATHOGENESIS OF ATHEROSCLEROSIS
  • INITIATION OF ATHEROMA
  • The Role of Endothelium
  • The Role of LDL Particles
  • The Role of Inflammation
  • Monocyte-Derived Macrophages
  • LDL and Inflammation
  • Atheroprotective Mechanisms and Inflammation
  • Retention of Macrophages
  • T Lymphocytes
  • THE FORMATION OF ATHEROSCLEROTIC PLAQUE
  • Apoptosis and Efferocytosis of Macrophages
  • The Role of Vascular Smooth Muscle Cells
  • Neovascularization
  • CLINICAL IMPLICATIONS OF ATHEROSCLEROSIS
  • GENETICS OF CORONARY ARTERY DISEASE
  • ABO Blood Groups
  • Lipid-Associated Genes
  • Other Atherosclerosis-Related Genes
  • The Role of microRNAs
  • ATHEROSCLEROSIS: THERAPEUTIC OPTIONS
  • REFERENCES
  • 3 - The Role of Genetics in Acute Coronary Syndrome
  • INTRODUCTION
  • CLOPIDOGREL
  • Metabolism and Pharmacokinetics
  • Absorption and Role of P-glycoprotein
  • Hepatic Carboxylation and Oxidation
  • Effect of Genotypic Polymorphisms
  • ABCB1
  • CYP2C19
  • Nomenclature
  • CYP2C19*2 and Other Loss-of-Function Alleles
  • Pharmacokinetics/Pharmacodynamics
  • Clinical Trials and Meta-analyses
  • CYP2C19*17 Gain of Function Allele
  • Incidence of CYP2C19 Alleles in Specific Ethnic Groups
  • CYP3A4
  • CYP1A2
  • Paraoxonase 1
  • CYP4F2
  • Platelet Surface Receptors
  • P2Y12 Receptor
  • Platelet Endothelial Aggregation Receptor-1
  • Protease Activated Receptors
  • Nongenetic Factors
  • Clopidogrel and Proton Pump Inhibitors
  • PRASUGREL
  • Metabolism
  • Pharmacokinetics, Pharmacodynamics, and Clinical Trials
  • TICAGRELOR
  • Metabolism
  • Pharmacokinetics, Pharmacodynamics, and Clinical Trials
  • Compliance
  • Drug-Drug Interactions
  • GENOTYPING ASSAYS
  • COST-EFFECTIVENESS OF GENOTYPING
  • GENETIC POLYMORPHISMS RELATED TO ASPIRIN
  • FUTURE DIRECTIONS
  • Cilostazol and Role of Genetics
  • Statins and the Role of Genetics
  • SUMMARY: ROLE OF GENOTYPING IN ACUTE CORONARY SYNDROME
  • REFERENCES
  • 4 - Global Epidemiology and Incidence of Cardiovascular Disease
  • INTRODUCTION
  • GLOBAL BURDEN OF DISEASE: REPORTING METRICS
  • MEASURING THE GLOBAL BURDEN OF CARDIOVASCULAR DISEASE
  • Limitations of the Quality and Completeness of Data
  • CHANGES IN TOTAL DISEASE BURDEN VERSUS CVD
  • GLOBAL CARDIOVASCULAR MORTALITY
  • Global CVD Mortality Rates by WHO Region
  • Global CVD Mortality Rates by WHO/World Bank Region
  • Age and Gender Global CVD Mortality Rates
  • GLOBAL CARDIOVASCULAR DALY
  • Global CVD Lost DALYs Within WHO Regions
  • Global CVD Lost DALYs by WHO/World Bank Region
  • Age and Gender Global CVD Loss of DALYs
  • RISK FACTORS FOR CVD GLOBALLY
  • Hypertension
  • Diabetes Mellitus
  • Tobacco
  • Dyslipidemia
  • Physical Activity
  • Alcohol Consumption
  • EPIDEMIOLOGICAL TRANSITION
  • AGING POPULATION
  • ETHNICITY
  • European
  • Chinese
  • South Asian
  • Hispanic
  • Blacks of African Origin
  • MIGRATION
  • URBANIZATION
  • SPECIFIC CVD CONDITIONS
  • Ischemic Heart Disease
  • Atrial Fibrillation
  • Heart Failure
  • Congenital Heart Disease
  • CONCLUSIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 5 - Lifestyle Choices, Risk Factors, and Cardiovascular Disease
  • INTRODUCTION
  • DIETARY PATTERNS AND CV RISK
  • Individual Nutrients
  • Fats
  • Carbohydrates
  • Sodium and Potassium
  • Food Groups
  • Red Meat
  • Fish
  • Fruit and Vegetables
  • Cocoa Products
  • Drinks
  • Soft Drinks
  • Alcoholic Beverages
  • Tea
  • Overall Dietary Patterns
  • Mediterranean Diet
  • Western Diet
  • PHYSICAL ACTIVITY/FITNESS AND CV RISK
  • OBESITY AND CV RISK
  • SMOKING AND CV RISK
  • PSYCHOLOGICAL FACTORS AND CV RISK
  • CONCLUSION
  • REFERENCES
  • 6 - The Contribution of Pollutants and Environmental Chemicals in Cardiovascular Disease
  • INTRODUCTION
  • AIR POLLUTANTS
  • Particulate Matter and Cardiovascular Disease
  • Ozone Pollution
  • Environmental Smoke
  • METAL TOXICITY
  • Lead
  • Cadmium
  • Mercury
  • Arsenic
  • CONCLUSIONS
  • REFERENCES
  • 7 - Genetic Susceptibility to Cardiovascular Diseases: From Mendelian Disorders to Common Variants
  • INTRODUCTION
  • GENETIC STUDIES: A METHODOLOGIC APPROACH
  • GENETIC POLYMORPHISMS IN CARDIOVASCULAR DISEASES
  • Polymorphisms of Lipid Metabolism (Table 7.1)
  • Polymorphisms Involved in Endothelial and Vascular Function (Table 7.1)
  • Polymorphisms Involved in Thrombosis/Fibrinolysis Cascades (Table 7.1)
  • Polymorphisms of Genes Involved in Inflammation (Table 7.1)
  • GENOME-WIDE LINKAGE AND ASSOCIATION STUDIES: LEAPS TOWARD INDIVIDUALIZED CARDIOVASCULAR MEDICINE?
  • Genome-Wide Association Studies and 9p21 Locus (Table 7.2)
  • Mendelian Randomization Studies
  • CONCLUSIONS
  • GLOSSARY
  • REFERENCES
  • 8 - Role of Conventional Risk Factors in Genetic Susceptibility to Cardiovascular Diseases
  • THE RELATIONSHIP OF RISK FACTORS AND GENETICS TO DISEASE
  • METHODS FOR ASSESSING CAUSALITY
  • RANDOMIZED CONTROLLED TRIALS
  • OBSERVATIONAL STUDIES
  • GENETIC STUDIES AND MENDELIAN RANDOMIZATION
  • Searching the Genome for Risk-Associated Variants
  • Identifying Causal Risk Factors
  • BLOOD LIPIDS
  • LDL Cholesterol
  • HDL Cholesterol and Triglycerides
  • INFLAMMATION
  • ANTHROPOMETRIC TRAITS AS RISK FACTORS
  • BEHAVIORAL AND ENVIRONMENTAL RISK FACTORS
  • Alcohol
  • Smoking
  • LIMITATIONS OF CAUSAL INFERENCE USING GENETICS
  • CONCLUSIONS
  • REFERENCES
  • 9 - Genetic Susceptibility in Biochemical and Physiological Traits
  • INTRODUCTION
  • HYPERTROPHIC CARDIOMYOPATHY
  • CHANNELOPATHIES
  • Long-QT Syndrome
  • Major Long-QT Genes
  • Minor Long-QT Genes
  • Jervell and Lange-Nielsen Syndrome
  • Andersen-Tawil Syndrome and Timothy Syndrome
  • Catecholaminergic Polymorphic Ventricular Tachycardia
  • Brugada Syndrome
  • CONNECTIVE TISSUE DISORDERS
  • Marfan Syndrome
  • Loeys-Dietz Syndrome
  • GENETIC DISORDERS LEADING TO ATHEROSCLEROSIS
  • Familial Hypercholesterolemia
  • Lipoxygenases
  • Myocyte Enhancer Factor 2A
  • Tangier Disease and Sitosterolemia
  • CARDIOVASCULAR PHARMACOGENETICS AND PHARMACOGENOMICS
  • Pharmacogenetics of Warfarin
  • REFERENCES
  • 10 - Interactions-Interrelationships Between Genetics and Environmental Factors in Cardiovascular Disease
  • INTRODUCTION
  • MODELS OF INTERACTION
  • Complementary Versus Antagonistic
  • Gene-Gene Interactions
  • Models of Disease Risk
  • Additive
  • Multiplicative
  • Additive Versus Multiplicative Model
  • ENVIRONMENTAL FACTORS
  • INTERACTIONS BETWEEN GENOTYPE, DIET, AND CORONARY HEART DISEASE
  • INTERACTIONS BETWEEN ALCOHOL AND CORONARY HEART DISEASE
  • INTERACTION BETWEEN APOE GENOTYPE, SMOKING, AND RISK OF CORONARY HEART DISEASE
  • ENVIRONMENTAL POLLUTANTS, EPIGENETICS, AND CARDIOVASCULAR DISEASE
  • DRUG-GENOME INTERACTIONS RELEVANT TO CARDIOVASCULAR DISEASE
  • GENE-ENVIRONMENTAL INTERACTIONS AND CONGENITAL HEART DISEASE
  • CONCLUSIONS
  • REFERENCES
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • L
  • M
  • N
  • O
  • P
  • R
  • S
  • T
  • V
  • W
  • Y
  • Back Cover

Dateiformat: EPUB
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat EPUB ist sehr gut für Romane und Sachbücher geeignet - also für "fließenden" Text ohne komplexes Layout. Bei E-Readern oder Smartphones passt sich der Zeilen- und Seitenumbruch automatisch den kleinen Displays an. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Dateiformat: PDF
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat PDF zeigt auf jeder Hardware eine Buchseite stets identisch an. Daher ist eine PDF auch für ein komplexes Layout geeignet, wie es bei Lehr- und Fachbüchern verwendet wird (Bilder, Tabellen, Spalten, Fußnoten). Bei kleinen Displays von E-Readern oder Smartphones sind PDF leider eher nervig, weil zu viel Scrollen notwendig ist. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Download (sofort verfügbar)

128,52 €
inkl. 19% MwSt.
Download / Einzel-Lizenz
ePUB mit Adobe DRM
siehe Systemvoraussetzungen
PDF mit Adobe DRM
siehe Systemvoraussetzungen
Hinweis: Die Auswahl des von Ihnen gewünschten Dateiformats und des Kopierschutzes erfolgt erst im System des E-Book Anbieters
E-Book bestellen

Unsere Web-Seiten verwenden Cookies. Mit der Nutzung dieser Web-Seiten erklären Sie sich damit einverstanden. Mehr Informationen finden Sie in unserem Datenschutzhinweis. Ok