New Experimental Probes for Enzyme Specificity and Mechanism

1. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis2. New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases3. Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase4. Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses5. Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces6. Kinetics and Mechanism for Reactions of Enzyme Pieces7. Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase8. Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase9. Innovative and emerging modalities of EGFR kinase inhibitors10. Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases11. Employing deuterium kinetic isotope effects to uncover the mechanism of (R)-3-hydroxybutyrate dehydrogenase12. Probing the mechanism of flavin action in the oxidative decarboxylation catalyzed by salicylate hydroxylase13. Kinetic Characterization of Methylthio-D-ribose-1-phosphate Isomerase14. The Role of Protein Motions in Catalysis15. The nickel-pincer coenzyme of lactate racemase: A case study of uncovering cofactor structure and biosynthesis16. Adaptation of Transient State Methods to Reveal the Mechanism of Mammalian Dihydropyrimidine Dehydrogenase17. Charge Resonance in Enzyme Redox Reactions18. Motions and Allostery in Human Glucokinase19. Kinetic Dissection of CRISPR CAS-920. Oxygenase PLP Chemistry21. Electron bifurcating flavoproteins