Industrial Scale Suspension Culture of Living Cells

Wiley-Blackwell (Verlag)
  • erschienen am 16. Juli 2014
  • |
  • 642 Seiten
E-Book | PDF mit Adobe-DRM | Systemvoraussetzungen
978-3-527-68334-5 (ISBN)
Comprehensive and comparative coverage of all suspension cell-based production methods, containing outstanding contributions from a balanced mix of industry and academia, and edited by leading figures at one of the largest companies using industrial-scale biotechnology processing.
All chapters adhere to a standardized structure and the editors have carefully avoided any overlaps in content. The following are included for each host or expression system presented:
(a) organisms, cells, expression systems, products,
(b) basic process design aspects,
(c) basic bioreactor design aspects,
(d) key factors affecting process economics,
(e) regulatory aspects,
(f) summary and outlook.
weitere Ausgaben werden ermittelt
The holder of a PhD in microbiology from the University of Fribourg, Switzerland, Hans-Peter Meyer served as VP Strategic Projects Biotechnology at Lonza until his retirement in early 2014. Following three years of postdoctoral studies in Stockholm, at the University of Pennsylvania, Philadelphia, and Lehigh University, Bethlehem, USA, in 1982 he joined Prof. Armin Fiechter's team as group leader at the ETH in Zürich before starting at Lonza in Visp, Switzerland in 1986, where he held a number of positions in R&D, manufacturing, and sales & marketing. He recently joined the faculty of the University of Applied Sciences and Arts of Western Switzerland, and also remains an expert at the Commission for Technology & Innovation (CTI) of the Swiss Federal Confederation.

Diego R. Schmidhalter is head of R&T within the pharma and biotechnology custom manufacturing division at Lonza Switzerland. He holds a PhD in microbiology from the University of Fribourg, Switzerland, and carried out two years of postdoctoral studies at Genencor International, California, USA. He has held various management positions at Lonza, including head of microbial anufacturing, head of the Biopharma R&D Services business, and as head of Microbial Manufacturing Science and Technology, as well as being a member of the Biopharmaceuticals business team. Dr. Schmidhalter has over 20 years of experience in the biotechnology industry in biopharmaceuticals and biochemicals process development and manufacturing, technology transfer, scaling-up fermentations right up to the 50,000-liter scale, and within the biopharmaceuticals related regulatory environment.
The History and Economic Relevance of Industrial Scale Suspension Culture of Living Cells (Hans-Peter Meyer, Diego R. Schmidhalter)

Bacterial Suspension Cultures (Patrick Sagmeister, Mohammad Jazini, Joachim Klein, and Christoph Herwig)
Yeast Suspension Culture (Diethard Mattanovich, Carmen Jungo, Jana Wenger, Michal Dabros, and Michael Maurer)
Filamentous Fungi Fermentation (Anders Norregaard, Stuart M. Stocks, Mads O. Albaek, John M. Woodley, and Krist V. Gernaey)

Microalgae Grown Under Heterotrophic and Mixotrophic Conditions (Karin Kovar, Pavel Pribyl, and Markus Wyss)
Recombinant Protein Production with Microalgae (Alexandre Lejeune, Rémy Michel, and Aude Carlier)
Suspension Culture of Microorganisms (Algae and Cyanobacteria)under Phototrophic Conditions (Peter Bergmann, Astrid Nissen, Lars Beyer, Peter Ripplinger, Walter Trösch)
Suspension Culture of Plant Cells under Heterotrophic Conditions (Nicole Imseng, Stefan Schillberg, Cornelia Schürch, Daniel Schmid, Kai Schütte, Gilbert Gorr, Dieter Eibl, and Regine Eibl)
Suspension Culture of Plant Cells under Phototrophic Conditions (Holger Niederkrüger, Paulina Dabrowska-Schlepp, and Andreas Schaaf)

Suspension Culture of Protozoan Organisms (M.W.W. Hartmann and R. Breitling)
Industrial Large Scale of Suspension Culture of Insect Cells (António Roldão, Manon Cox, Paula Alves, Manuel Carrondo, and Tiago Vicente)
Avian Suspension Culture Cell Lines for Production of Vaccines and Other Biologicals (Manfred Reiter, Daniel Portsmouth, and P. Noel Barrett)
Large Scale Suspension Culture of Mammalian Cells (Richard M Alldread, John R. Birch, Hilary K Metcalfe, Suzanne Farid, Andrew J. Racher, Robert J. Young, and Mohsan Khan)

Pillars of Regenerative Medicine: Therapeutic Human Cells and Their Manufacture
(Christian van den Bos, Robert Keefe, Carmen Schirmaier, and Michael McCaman)
Virus Production Under Suspension Conditions (O.-W. Merten, W.A.M. Bakker, J. Vorlop, M. Reiter, G. Visnovsky, V. Jäger, M. Merabishvili, and U. Reichl)
Cultivable Marine Organisms as a Source of New Products (Jean-Michel Kornprobst)

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