Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.
Chapter 1 Cancer Metastasis: Tracking and Attacking a Moving Target
Chapter 2 The generation, detection, and prevention of genomic instability during cancer progression and metastasis.
Chapter 3 DNA damage response pathways in cancer predisposition and progression
Chapter 4 Mathematical modeling for DNA repair, carcinogenesis and cancer detection
Chapter 5 Animal models of metastasis
Chapter 6 Microenvironmental Control Of Metastatic Progression.
Chapter 7 Mechanotransduction, metastasis and genomic instability
Chapter 8 Immunomodulation and Genomic Instability
Chapter 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability.
Chapter 10 Nanomedicine - Nanoparticles in Cancer Imaging and Therapy