Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer's, stroke and multiple sclerosis.
- Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging
- Features sections on diagnosis and biomarkers of neurological aging, Alzheimer's and stroke
- Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter
- Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations
- Includes more than 500 illustrations and tables
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 500 illustrations (250 in full color)
Dateigröße
ISBN-13
978-0-12-818001-3 (9780128180013)
Schweitzer Klassifikation
I. Introductory chapters: Setting the scene for the neuroscience of aging1. The concept of productive aging2. Quality of life in the over 80s3. Successful aging and diet4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral perspective5. The brain in life span: Use of phase fMagnetic Resonance Imaging (MRI)6. Neuronal structure in aging: cytoskeleton in health and disease7. Sporadic Alzheimer's Triad: Age, Sex, and ApoE8. How polymorphisms impact: BDNF polymorphism, inhibitory performance and the elderly9. Menopause as an aging process and alcohol misuse10. Brain banking and aging
II. Impairments and Diseases11. Dementia or no dementia in the very elderly. Why?12. Neuropsychology, Social Cognition and Loss of Insight in Frontotemporal Dementia13. Neuroinflammation in the elderly14. Cortical microinfarcts and the aging brain15. Vascular brain injury and neurodegeneration in elderly racial and ethnic minority populations16. Hearing loss amongst the elderly17. Aging Auditory Cortex: The Impact of Reduced Inhibition on Function18. Aging and vestibular disorders19. Brain aging in HIV and antiretrovirals 20. Antioxidants, Methylmercury, and Aging21. Aging and the effects of ethanol on the brain: Comparing the effects of different aging
III. Biomarkers and Diagnosis 22. Aging brain: Radiological biomarkers23. Plasma ADAM10 as a biomarker of mental impairment in the elderly24. Circulating microRNAs as biomarkers of healthy elderly25. DHEA as a biomarker of aging in humans and nonhuman primates: Synthesis, neuroprotection and cognitive function26. Evaluation of subjective memory abilities in elderly people27. The Functional Activities Questionnaire: Applications to aging28. Autobiographical memory as a diagnostic tool in aging29. Assessment tools for subjective memory abilities in elderly people30. Knowledge of Memory Aging
IV. Management and Treatments31. Pharmacological use of transient receptor potential (TRP) ion channel antagonists in neurological disease: Effects on swallowing and implications for nutrition32. Aripiprazole: Features and use in the aged33. Cognition-Enhancing Drugs and Applications to Aging34. Creatine supplementation and impact on the aging brain35. Photobiomodulation as a brain-boosting strategy in aging36. Innovation in deep brain stimulation in aging: a focus on Parkinson Disease37. Exergames: What they are and how they can be used to improve cognition in aging38. Linking cognitive decline and ballroom dance as a therapeutic intervention in the elderly39. Active experiencing training in the elderly40. Psychiatric self-management, smartphone apps and older adults41. Psychosocial Interventions for Suicide Prevention in the Elderly: Advances and Future Directions
V. Models and Modelling42. D-galactose-induced aging and brain mitochondria43. Drosophila as a model organism in ageing research44. The Zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging: applications and observation45. Murine models of primary Tauopathy as a model of aging46. Modelling nutrition and brain aging in rodents47. Modelling primates and neurological aging: A focus on Alzheimer's disease48. Linking aging and animal models to neurodegeneration: The Striatum, Substantia Nigra and Parkinson's Disease49. Behavioral evaluation of aging
VI. Resources50. Research and recommended resources in the neuroscience of aging
