Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical Applications

A. Introduction to the Acute Phase Response 1. The Acute Phase Response: An Overview 2. The Negative Acute Phase Proteins 3. Extrahepatic Synthesis of Acute Phase Proteins B. The Major Acute Phase Proteins: Their Structure and Possible Function in Acute Phase Response 4. Structure and Function of Human C-Reactive Protein 5. The SAA Lipoprotein Family 6. The ?1-Acid Glycoprotein: Structure and Possible Functions in the Acute Phase Response 7. Proteinase Inhibitors: An Overview of Their Structure and Possible Function in the Acute Phase 8. ?1-Antitrypsin: Structure, Function, Physiology 9. Fibrinogen: A Multifunctional Acute Phase Protein 10. Haptoglobin: Retrospectives and Perspectives 11. The Acute Phase Complement Proteins 12. Rat ?2-Macroglobulin and Related a-Macroglobulins in the Acute Phase Response 13. Rat Thiostatin: Structure and Possible Function in the Acute Phase Response C. Systems in which to Study Regulation of Acute Phase Proteins 14. Experimental Systems for Studying Hepatic Acute Phase Response D. The Cytokines and Hormones Implicated in Acute Phase Protein Regulation 15. Biological Perspectives of Cytokine and Hormone Networks 16. Interleukin-6 17. Interleukin-11: Molecular Biology, Biological Activities, and Possible Signaling Pathways 18. The Role of Oncostatin M in the Acute Phase Response 19. Tumor Necrosis Factor 20. Interleukin-6 Receptor E. Regulation of Acute Phase Protein Gene Expression 21. Regulation of C-Reactive Protein, Haptoglobin, and Hemopexin Gene Expression 22. Serum Amyloid A Gene Regulation 23. Regulation of ?1-Acid Glycoprotein Genes and Relationship to Other Type 1 Acute Phase Plasma Proteins 24. Transcriptional Regulation of the Human C3 Gene 25. Regulation of the ?2-Macroglobulin Gene 26. Regulation of the Rat ?2-Macroglobulin Gene by Interleukin-6 and Leukemia Inhibitory Factor 27. Regulation of the Rat Thiostatin Gene 28. Cytokine Regulation of the Mouse SAA Gene Family F. Signal Transduction of Cytokines in Hepatocytes 29. Signal Transduction Mechanisms Regulating Cytokine-Mediated Induction of Acute Phase Proteins G. Post-Transcriptional Processes 30. Intracellular Maturation of Acute Phase Proteins 31. Control of Glycosylation Alterations of Acute Phase Glycoproteins 32. Post-Translational Regulation of C-Reactive Protein Secretion H. Clinical Applications 33. Cytokine Measurements in Disease 34. Diagnostic and Prognostic Value of Interleukin-6 Measurements in Human Disease 35. The Measurement of Acute Phase Proteins as Disease Markers 36. Glycoforms of ?1-Acid Glycoprotein as Disease Markers