The management of liver tumors is a nexus of interactions among multiple medical specialties, including radiation oncology. A multitude of liver-directed therapies are available for patients, ranging from surgery and liver transplantation to intra-arterial therapies, thermal ablation procedures, systemic therapies, and radiation treatments. With the introduction of hypofractionated irradiation, particle therapy, and radioembolization, there is growing interest in the use of radiation as a treatment for liver malignancies.
This book examines basic principles of the management of liver tumors. The evolving roles of x-ray and particle therapies as well as radioembolization in the treatment of liver tumors is the main focus. A theme of multidisciplinary management is also emphasized, as surgical, interventional and systemic therapies are reviewed.
A unique resource that discusses the role of radiation treatment in the context of other liver-directed therapies, Radiation Therapy for Liver Tumors is of broad interest to radiation oncologists, surgeons, hepatologists, medical oncologists, and radiologists.
Jeffrey Meyer, MD, MS, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA, Tracey E. Schefter, MD, Department of Radiation Oncology, University of Colorado Comprehensive Cancer Center, Aurora, CO, USA
Part I: Fundamentals.- Liver Anatomy and Function.- Imaging Characteristics of Normal liver and liver tumors.- Assessment of Liver Function: Focus on the ALBI Score.- Radiation Oncology: Fundamentals and Controversies.- Radiation Sensitivity of the Liver: Models and Clinical Data.- Part II: Principles of Surgery, Intra-arterial Therapies, and Thermal Ablation.- Surgical Considerations.- Principles of Intra-arterial Therapies.- Principles of Thermal Ablation.- Part III: Principles of Radiation Therapy.- External beam radiation therapy for liver tumors: Simulation, Treatment Planning, and Advanced Delivery Techniques.- Particle Radiation Therapy for Liver Tumors: Simulation and Treatment Planning.- Yttrium-90 Selective Internal Radiation Therapy.- Interstitial Brachytherapy For Liver Tumors: Practical Issues.- Part IV: Hepatocellular Carcinoma.- Hepatocellular Carcinoma: Epidemiology, Basic Principles of Treatment, and Clinical Data.- Radiation Therapy for Hepatocellular Carcinoma: Clinical Data.- Part V: Intrahepatic and Hilar Cholangiocarcinoma.- Intrahepatic and Hilar Cholangiocarcinoma: Epidemiology, Basic Principles of Treatment, and Clinical Data.- Radiation Therapy for Intrahepatic and Hilar Cholangiocarcinoma: Clinical Data.- Part VI: Liver Metastases.- Liver Metastases: Basic Principles of Treatment and Clinical Data.- Radiation Therapy for Liver Metastases: Clinical Data.- Part VII: Perspectives on Multidisciplinary Management.- Multidisciplinary Model for Liver Tumors.- Part VIII: Future Directions.- Radiation Therapy for Liver Tumors: Future Directions.