In Situ Tissue Regeneration

Host Cell Recruitment and Biomaterial Design
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 17. Juli 2016
  • |
  • 458 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-802500-0 (ISBN)
 

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.


  • Explores the body's ability to mobilize endogenous stem cells to the site of injury
  • Details the latest strategies developed for inducing and supporting the body's own regenerating capacity
  • Presents smart biomaterials in cell-based tissue engineering applications-from the cell level to applications-in the first unified volume
  • Features chapter authors and editors who are authorities in this emerging field
  • Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 8,28 MB
978-0-12-802500-0 (9780128025000)
012802500X (012802500X)
weitere Ausgaben werden ermittelt
  • Front Cover
  • In Situ Tissue Regeneration
  • Dedication
  • In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design
  • Copyright
  • Contents
  • List of Contributors
  • Preface
  • 01 - INTRODUCTION
  • 1 - FUNDAMENTALS OF IN SITU TISSUE REGENERATION
  • INTRODUCTION
  • STRATEGY: IN SITU TISSUE REGENERATION
  • DESIGN CONSIDERATIONS: BIOMATERIAL SCAFFOLDS
  • APPLICATIONS OF IN SITU TISSUE REGENERATION
  • CONCLUSION AND FUTURE DIRECTIONS
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 02 - ENDOGENOUS CELL SOURCES
  • 2 - STEM CELL HOMING
  • INTRODUCTION
  • HOMING OF HEMATOPOIETIC STEM CELLS TO BONE MARROW NICHES
  • CHANGES IN THE BONE MARROW LEVEL OF CHEMOATTRACTANTS FOR HEMATOPOIETIC STEM CELLS
  • HOMING OF NONHEMATOPOIETIC STEM CELLS TO DAMAGED ORGANS
  • TO MODULATE HOMING GRADIENTS AS A STRATEGY TO DELIVER THERAPEUTIC STEM CELLS TO THE DAMAGED ORGANS
  • CONCLUSIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 3 - IMMUNOLOGY: HOST RESPONSES TO BIOMATERIALS
  • INTRODUCTION
  • INNATE IMMUNITY
  • CELL TYPES
  • COMPLEMENT
  • ADAPTIVE IMMUNITY
  • T CELL DEVELOPMENT
  • HELPER T CELLS
  • B CELLS
  • BIOMATERIALS
  • ACUTE RESPONSE TO BIOMATERIALS
  • CHRONIC IMMUNE RESPONSE TO BIOMATERIALS
  • Adhesion of macrophages
  • Foreign body response
  • ADAPTIVE IMMUNE RESPONSE TO BIOMATERIALS
  • BIOMATERIAL COMPOSITION INFLUENCES THE IMMUNE RESPONSE
  • CONCLUSION
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • REFERENCES
  • 4 - FOREIGN BODY REACTION AND STEM CELL RESPONSES
  • INTRODUCTION
  • IMPLANT-MEDIATED INFLAMMATORY RESPONSES AND STEM CELL RECRUITMENT
  • FOREIGN BODY REACTIONS VERSUS WOUND HEALING RESPONSES
  • IMPLANT-MEDIATED STEM AND PROGENITOR CELL RECRUITMENT
  • INFLAMMATION-MEDIATED STEM CELL RECRUITMENT
  • INFLAMMATORY CYTOKINES AND STEM CELL RECRUITMENT
  • FIBROCYTES-PROGENITOR FIBROTIC CELLS-AND THEIR ROLE IN TISSUE REACTIONS TO MATERIALS
  • FIBROCYTES-FIBROBLAST PROGENITOR CELLS-AND THEIR ROLE IN TISSUE REACTIONS TO MATERIALS
  • INFLUENCE OF INFLAMMATORY RESPONSES ON FIBROCYTES RECRUITMENT
  • SOURCE OF FIBROCYTES
  • NEW STRATEGIES TO ENGINEER STEM CELL RESPONSES FOR TISSUE REGENERATIONS
  • TISSUE ENGINEERING SCAFFOLDS FOR DIRECTING AUTOLOGOUS STEM CELL RESPONSES
  • PROGRAMMED STEM CELL DIFFERENTIATION TO ALTER FIBROCYTE REACTIONS
  • CYTOKINE-MEDIATED STEM CELL RECRUITMENT AND TISSUE REGENERATION
  • CONCLUSIONS
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • REFERENCES
  • 03 - BIOCHEMICAL AND PHYSICAL CUES
  • 5 - ROLES OF ENDOGENOUS GROWTH FACTORS AND SMALL PEPTIDES IN IN SITU TISSUE REGENERATION
  • INTRODUCTION
  • STEM CELL MOBILIZATION AND VASCULOGENESIS
  • STROMAL CELL-DERIVED FACTOR 1 ALPHA
  • VASCULAR ENDOTHELIAL GROWTH FACTOR
  • GRANULOCYTE-COLONY STIMULATING FACTOR
  • SUBSTANCE-P
  • EXPERIMENTAL STRATEGIES TO IDENTIFY STEM CELL TRAFFICKING AND HOMING USING CANDIDATE MOLECULES
  • CONCLUSION
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 6 - SMALL MOLECULES: CONTROLLING CELL FATE AND FUNCTION
  • INTRODUCTION
  • TARGET CELLS FOR SMALL MOLECULE REGULATION IN REGENERATIVE MEDICINE
  • HUMAN EMBRYONIC STEM CELLS
  • HUMAN INDUCED PLURIPOTENT STEM CELLS
  • ADULT STEM CELLS
  • TERMINALLY DIFFERENTIATED CELLS
  • IN VITRO/EX VIVO REGULATION OF HUMAN CELLS BY SMALL MOLECULES
  • SMALL MOLECULES FOR HESC/HIPSC CELL PROLIFERATION AND MAINTENANCE
  • SMALL MOLECULES FOR GUIDED PLURIPOTENT STEM CELL DIFFERENTIATION
  • SMALL MOLECULES FOR HIPSC GENERATION
  • SMALL MOLECULES FOR IN VITRO ADULT STEM CELL REGULATION
  • SMALL MOLECULES FOR IMPROVING SAFETY OF PLURIPOTENT STEM CELL-DERIVED CELLS
  • USING SMALL MOLECULES TO ENHANCE IN VIVO TISSUE REGENERATION
  • SMALL MOLECULES FACILITATING THE PROLIFERATION AND DIFFERENTIATION OF ADULT STEM CELLS
  • Small molecules promoting neurogenesis
  • Small molecules promoting cardiomyocyte regeneration
  • Small molecules promoting regeneration of other tissues
  • ENHANCING THE PROLIFERATION/FUNCTION OF DIFFERENTIATED CELLS
  • INDUCING REPROGRAMMING AND TRANSDIFFERENTIATION OF FIBROBLASTS TO TARGET CELLS
  • CURRENT STATUS AND FUTURE DIRECTIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 7 - SMALL RNA DELIVERY FOR IN SITU TISSUE REGENERATION
  • INTRODUCTION
  • STRATEGIES FOR SMALL RNAS IN TISSUE REGENERATION
  • RNA INTERFERENCE
  • SMALL RNAS: SMALL INTERFERING RNAS AND MICRORNAS
  • DESIGN CONSIDERATION FOR SMALL RNA DELIVERY
  • GENERAL DELIVERY STRATEGY OF SMALL RNAS
  • POLYMERIC DELIVERY SYSTEM
  • ADVANCED CARRIER MATERIALS FOR SMALL RNA DELIVERY
  • SMALL RNAS FOR IN SITU TISSUE REGENERATION
  • REGULATION OF STEMNESS
  • BONE REGENERATION
  • CARTILAGE REGENERATION
  • SKELETAL MUSCLE REGENERATION
  • NERVE REGENERATION
  • CARDIAC TISSUE REGENERATION
  • WOUND HEALING
  • VASCULARIZATION
  • OTHER APPLICATIONS
  • SUMMARY AND FUTURE DIRECTIONS
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • ACKNOWLEDGMENT
  • REFERENCES
  • 8 - MICRO- AND NANOTOPOGRAPHICAL CUES GUIDING BIOMATERIAL HOST RESPONSE
  • INTRODUCTION
  • EXTRACELLULAR MATRIX TOPOGRAPHY AND ITS EFFECT ON CELLULAR RESPONSE
  • CONTROLLED SUBSTRATE TOPOGRAPHY GUIDING IN VIVO HOST RESPONSE
  • MICRO- AND NANOTOPOGRAPHY AND ITS EFFECT ON WATER INTERACTION
  • MICRO- AND NANOTOPOGRAPHY AND ITS EFFECT ON PROTEIN ADSORPTION
  • DIFFERENT FABRICATION TECHNIQUES USED TO CREATE MICRO-/NANOSURFACE TOPOGRAPHY
  • PHOTOLITHOGRAPHY AND ELECTRON BEAM LITHOGRAPHY
  • SOFT LITHOGRAPHY
  • ELECTROSPINNING
  • MICROSTEREOLITHOGRAPHY
  • IN VITRO ASSESSMENT OF MICRO- AND NANOTOPOGRAPHIC FEATURES
  • THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON CELL MORPHOLOGY AND MIGRATION
  • THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON CELL PROLIFERATION
  • THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON STEM CELL DIFFERENTIATION
  • The effect of topographic modulation on mesenchymal stem cell differentiation
  • The effect of topographic modulation on embryonic stem cells
  • The effect of topographic modulation on adipose-derived stem cells
  • USE OF TOPOGRAPHICAL MODIFICATIONS TO ENGINEER FUNCTIONAL TISSUE-ENGINEERED CONSTRUCTS
  • Tendon tissue engineering
  • Vascular tissue engineering
  • Cardiac tissue engineering
  • MODULATION OF SURFACE TOPOGRAPHY AND ITS EFFECT ON ASSOCIATED IN VIVO RESPONSE
  • EFFECTS ON THE BONE IMPLANTS TISSUE INTEGRATION
  • SUMMARY
  • REFERENCES
  • 9 - MECHANOBIOLOGY AND MECHANOTHERAPY IN TISSUE ENGINEERING
  • INTRODUCTION
  • CELLS AND THE PHYSICAL ENVIRONMENT
  • MECHANOSENSITIVITY OF CELLS
  • MECHANOSENSORS, MECHANORECEPTORS, AND MECHANOSENSITIVE NOCICEPTORS
  • MECHANOSIGNALING PATHWAYS
  • MECHANOBIOLOGY AND MECHANOTHERAPY
  • MECHANOTHERAPY AT THE MOLECULAR LEVEL
  • MECHANOTHERAPY AT A CELLULAR LEVEL
  • MECHANOTHERAPY AT THE TISSUE LEVEL
  • MECHANOTHERAPY FOR DISEASES
  • DEVELOPMENT OF NEW MECHANOTHERAPIES FOR TISSUE ENGINEERING
  • CONCLUSION
  • REFERENCES
  • 04 - SMART BIOMATERIALS DEVELOPMENT
  • 10 - A BIOMIMETIC STRATEGY TO DESIGN BIOMATERIALS FOR IN SITU TISSUE REGENERATION
  • INTRODUCTION
  • BIOMIMETIC MATERIALS
  • EXTRACELLULAR MATRIX-MIMETIC BIOACTIVE MATERIALS
  • Cell-adhesive or enzyme-sensitive peptides
  • Growth factor bearing or binding biomaterials
  • PHYSICOCHEMICAL SIGNALS FOR CONTROLLING CELL FATES
  • Bioactive molecules for controlling stem cell fates
  • Substrates with controlled topographical cues
  • Substrate elasticity/stiffness and mechanical cues
  • Electrical stimuli
  • DESIGNED STRUCTURE OF PEPTIDE-BASED MOLECULES
  • Growth factor-mimicking peptides
  • Peptide amphiphiles
  • SUMMARY AND FUTURE PERSPECTIVES
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 11 - IMPACT OF MATRIX DYNAMIC PROPERTIES ON STEM CELL VIABILITY
  • INTRODUCTION
  • VIABILITY OF HUMAN MESENCHYMAL STEM CELLS IN TWO HYDROGELS
  • STIFFNESS AND RELAXATION SPECTRA OF TWO HYDROGELS
  • NANOSCALE STRUCTURAL DIFFERENCES DEFINING FIBER DYNAMICS
  • CONCLUSIONS
  • GLOSSARY
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 12 - FUNCTIONALIZED POLYMERIC BIOMATERIALS FOR IN SITU TISSUE REGENERATION
  • INTRODUCTION
  • STRATEGIES FOR THE FUNCTIONALIZED POLYMERIC SCAFFOLD
  • BIOMATERIALS FOR FUNCTIONALIZED POLYMERIC SCAFFOLD
  • SCAFFOLDING SYSTEM
  • CHEMOKINE SIGNALING
  • STEM CELL RECRUITING FACTORS
  • DESIGN CONSIDERATIONS OF FUNCTIONALIZED POLYMERIC SCAFFOLDS
  • IN SITU TISSUE REGENERATION USING THE FUNCTIONALIZED POLYMERIC SCAFFOLDS
  • CONCLUSION AND FUTURE TECHNOLOGICAL CHALLENGES
  • REFERENCES
  • 13 - TISSUE-DERIVED MATRICES
  • INTRODUCTION
  • COMPOSITION OF THE EXTRACELLULAR MATRIX
  • FIBROUS PROTEINS
  • PROTEOGLYCANS
  • GLYCOPROTEINS
  • FUNCTIONS OF NATIVE EXTRACELLULAR MATRIX
  • STRUCTURAL FUNCTION OF THE EXTRACELLULAR MATRIX
  • REGULATION OF THE ACTIVITY OF OTHER EXTRACELLULAR MOLECULES
  • Regulation of growth factor signaling
  • Regulation of proteolytic enzymes
  • FUNCTIONAL INTERACTIONS OF THE EXTRACELLULAR MATRIX WITH EMBEDDED CELLS
  • The ECM interacts with cells via specific receptors
  • ECM physical properties can affect stem cell fate
  • ECM physical properties regulate branching morphogenesis in development
  • TISSUE-DERIVED MATRICES FOR TISSUE ENGINEERING
  • METHODS FOR THE REMOVAL OF CELLS FROM TISSUE-DERIVED MATRICES
  • Physical protocols to decellularize tissues
  • Chemical methods to decellularize tissues
  • Biological methods to decellularize tissues
  • Delivery of decellularizing solutions
  • DESIRABLE PROPERTIES OF TISSUE-DERIVED MATRICES
  • CURRENT CLINICAL APPLICATIONS FOR TISSUE-DERIVED MATRICES
  • DERMAL-DERIVED MATRICES FOR SOFT TISSUE RECONSTRUCTION
  • PERICARDIAL-DERIVED MATRICES FOR VASCULAR RECONSTRUCTIONS
  • TISSUE-DERIVED MATRICES FOR HEART VALVE REPLACEMENTS
  • FUTURE DIRECTIONS FOR TISSUE-DERIVED MATRICES
  • FUTURE ADVANCES RELATING TO TISSUE-DERIVED MATRICES
  • FUNCTIONALIZATION OF TISSUE-DERIVED MATRICES BY CELLULAR RESEEDING
  • IN VITRO RESEEDING OF TISSUE-DERIVED MATRICES
  • Embryonic stem cells
  • Adult stem cells
  • Induced pluripotent stem cells
  • In vivo reseeding of tissue-derived matrices
  • APPLICATIONS FOR RESEEDED TISSUE-DERIVED MATRICES
  • Adaptive growth of tissue-derived matrices
  • Organ-derived matrices for organ engineering
  • Bioartificial organs for transplantation
  • CONCLUSION
  • GLOSSARY
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • REFERENCES
  • 05 - TISSUE-SPECIFIC APPLICATIONS
  • 14 - SYNOVIAL JOINT: IN SITU REGENERATION OF OSTEOCHONDRAL AND FIBROCARTILAGINOUS TISSUES BY HOMING OF ENDOGENOUS CELLS
  • INTRODUCTION
  • CURRENT TREATMENTS AND BIOLOGICALLY BASED APPROACHES
  • ARTICULAR CARTILAGE LESIONS
  • Cell delivery matrices and scaffolds
  • Matrix-induced autologous chondrocytes implantation
  • Hydrogels
  • Hybrid scaffolds: a combination of hydrogels and solid polymers
  • Bilayered scaffold for osteochondral tissue engineering
  • Anatomically shaped 3-D scaffolds for the regeneration of the entirearticular surface?of synovial joint
  • MENISCUS INJURY
  • Meniscectomy
  • Meniscus allograft transplantation (MAT)
  • Biomaterials-assisted meniscal regeneration
  • REGENERATION OF SYNOVIAL JOINTS BY ENDOGENOUS STEM/PROGENITOR CELL HOMING
  • REGENERATION OF ENTIRE ARTICULAR SURFACE BY ENDOGENOUS CELL HOMING
  • KNEE MENISCUS REGENERATION BY ENDOGENOUS CELL HOMING
  • SUMMARY AND PERSPECTIVES
  • REFERENCES
  • 15 - BIOENGINEERED STRATEGIES FOR TENDON REGENERATION
  • INTRODUCTION
  • BIOLOGICAL STRUCTURE AND EXTRACELLULAR MATRIX ROLE, MECHANICAL DEMANDS, AND BIOACTIVE?MOLECULES IN TENDON TISSUE
  • TENDON DEVELOPMENT AND PHYSIOLOGY
  • TENDON EXTRACELLULAR MATRIX: A CRITICAL PARTICIPANT IN TENDON FUNCTIONALITY
  • MECHANICAL BEHAVIOR OF TENDONS
  • BIOACTIVE MOLECULES
  • INTEGRATED APPROACHES TOWARD TENDON REPAIR
  • STEM CELLS AND THEIR ROLE IN TENDON TISSUE ENGINEERING
  • TENDON TISSUE ENGINEERING STRATEGIES WITH AND WITHOUT EXOGENOUS SCAFFOLDS
  • MECHANOTRANSDUCTION AND MECHANICAL STIMULI IN TENDON TISSUE ENGINEERING
  • MECHANICAL STIMULATION USING MAGNETIC FORCE FIELDS
  • CONCLUSIONS AND FUTURE PERSPECTIVES
  • LIST OF ACRONYMS AND ABBREVIATIONS
  • REFERENCES
  • 16 - IN SITU VOLUMETRIC MUSCLE REPAIR
  • INTRODUCTION
  • BASIC COMPONENTS FOR IN SITU MUSCLE REGENERATION
  • ENDOGENOUS CELLS
  • SCAFFOLDING SYSTEM
  • BIOACTIVE FACTORS
  • BIOACTIVE FACTORS DELIVERY SYSTEM
  • VARIOUS APPLICATIONS OF VOLUMETRIC MUSCLE REGENERATION IN SITU
  • LEG MUSCLE REGENERATION
  • ANTERIOR MUSCLE
  • POSTERIOR LEG MUSCLE
  • DIAPHRAGM REGENERATION
  • ABDOMINAL MUSCLE REGENERATION
  • CONCLUSION AND FUTURE PERSPECTIVES
  • ACKNOWLEDGMENT
  • REFERENCES
  • 17 - MENDING THE HEART THROUGH IN SITU CARDIAC REGENERATION
  • INTRODUCTION
  • INTRINSIC REGENERATIVE CAPACITY OF THE MAMMALIAN HEART
  • SYSTEMIC AND RESIDENT CARDIAC STEM OR PROGENITOR CELLS
  • PROTEIN LIGANDS FOR INDUCING CARDIAC REGENERATION
  • PROTEIN DELIVERY SYSTEMS FOR IN SITU CARDIAC REGENERATION
  • GENETICALLY ALTERING THE IN SITU REGENERATION CAPACITY OF THE HEART
  • ROLE OF MICRORNAS IN CARDIAC REGENERATION
  • DIRECT IN SITU EPIGENETIC REPROGRAMMING OF NONMYOCYTES INTO CARDIOMYOCYTES
  • CONCLUSIONS
  • REFERENCES
  • 18 - SKIN WOUND HEALING: SKIN REGENERATION WITH PHARMACOLOGICAL MOBILIZED STEM CELLS
  • INTRODUCTION
  • BONE MARROW AND SKIN
  • BONE MARROW-DERIVED CELL MOBILIZATION AFTER INJURY
  • DRUGS IN MOBILIZATION OF ENDOGENOUS STEM CELLS
  • AMD3100
  • Osteogenesis and bone healing
  • Wound healing in diabetes
  • GRANULOCYTE-COLONY STIMULATING FACTOR
  • FK506
  • SYNERGY
  • AMD3100 PLUS LOW-DOSE FK506 ACCELERATED SKIN WOUND HEALING
  • Full-thickness surgical excisional wound
  • Burns
  • AMD3100 PLUS LOW-DOSE FK506 IMPROVED THE QUALITY OF HEALING: HAIR FOLLICLE REGENERATION
  • MECHANISMS
  • AMD3100 AND LOW-DOSE FK506 SYNERGISTICALLY MOBILIZED STEM CELLS
  • LOW-DOSE FK506 INCREASED SDF-1-PRODUCING MACROPHAGES
  • DUAL DRUG TREATMENT INCREASED THE EXPRESSION OF ANGIOGENIC CYTOKINES
  • THE CRITICAL ROLE OF CD133 STEM CELLS IN IMPROVING WOUND HEALING
  • CONCLUSION
  • REFERENCES
  • 19 - IN SITU RENAL REGENERATION
  • INTRODUCTION
  • IN SITU RENAL REGENERATION: STRATEGY
  • STEM CELLS CONTRIBUTE TO RENAL REGENERATION
  • RENAL STEM OR PROGENITOR CELLS
  • BONE MARROW-DERIVED CELLS
  • NONRENAL STEM CELLS
  • SUMMARY AND FURTHER DIRECTIONS
  • REFERENCES
  • 20 - REGULATORY ASPECTS: REGULATION OF CELL-FREE BIOMATERIAL IMPLANTS
  • Introduction
  • MEDICAL DEVICES
  • CLASSIFICATION OF MEDICAL DEVICES
  • COMBINATION PRODUCTS
  • QUALITY SYSTEM REGULATIONS
  • REGULATORY SCOPE
  • INVESTIGATIONAL DEVICE EXEMPTION
  • SIGNIFICANT RISK STUDY
  • FDA REVIEW PROCESS
  • IDE PREPARATION
  • INVESTIGATIONAL DEVICE EXEMPTION SUBMISSION AND FDA RESPONSES
  • BENCH AND LABORATORY TESTING
  • TYPES OF BIOMATERIALS
  • Synthetic materials
  • Animal-derived materials
  • MATERIAL CHARACTERIZATION
  • STERILIZATION
  • BIOLOGICAL EVALUATION: BIOCOMPATIBILITY
  • TEST SELECTION
  • BIOCOMPATIBILITY TESTING
  • CROSS-REFERENCING OTHER DOCUMENTS
  • PRECLINICAL STUDIES
  • CLINICAL INVESTIGATION
  • SCOPE OF CLINICAL STUDY
  • PMA APPLICATION
  • CONCLUSION
  • REFERENCES
  • 21 - BUSINESS PERSPECTIVE: CASE STUDY: COMMERCIALIZED CELL-FREE CARDIOVASCULAR IMPLANT
  • INTRODUCTION
  • PRODUCT AND MARKET DYNAMICS
  • THE HISTORY OF PERCUTANEOUS CORONARY INTERVENTION
  • ABSORB BVS
  • COST AND COMPLEXITY OF GETTING A HIGHLY TECHNICAL IN SITU SCAFFOLD TO MARKET
  • DESIGN, DEVELOPMENT, AND MANUFACTURING
  • Balloon catheter and scaffold deliverability
  • Scaffold material and design
  • Coating the scaffold
  • Crimping the scaffold onto the delivery system
  • Packaging and sterilization
  • PRECLINICAL EVALUATION
  • Study objectives
  • Study duration
  • Scaffold integrity
  • CLINICAL EVALUATION
  • Global versus regional clinical strategy
  • Noninferiority, superiority, and differentiated endpoints
  • Absorb clinical trial program
  • CHANGING DYNAMICS OF HEALTHCARE
  • MARKET ACCESS AND REIMBURSEMENT
  • CASE STUDY: ABSORB: FOLLOW THE PATIENT THROUGH THE SYSTEM-SYMPTOMS DRIVE?RESOURCES
  • CONCLUSION AND VIEW TO THE FUTURE
  • REFERENCES
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Back Cover

Dateiformat: EPUB
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat EPUB ist sehr gut für Romane und Sachbücher geeignet - also für "fließenden" Text ohne komplexes Layout. Bei E-Readern oder Smartphones passt sich der Zeilen- und Seitenumbruch automatisch den kleinen Displays an. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Dateiformat: PDF
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat PDF zeigt auf jeder Hardware eine Buchseite stets identisch an. Daher ist eine PDF auch für ein komplexes Layout geeignet, wie es bei Lehr- und Fachbüchern verwendet wird (Bilder, Tabellen, Spalten, Fußnoten). Bei kleinen Displays von E-Readern oder Smartphones sind PDF leider eher nervig, weil zu viel Scrollen notwendig ist. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Download (sofort verfügbar)

128,52 €
inkl. 19% MwSt.
Download / Einzel-Lizenz
ePUB mit Adobe DRM
siehe Systemvoraussetzungen
PDF mit Adobe DRM
siehe Systemvoraussetzungen
Hinweis: Die Auswahl des von Ihnen gewünschten Dateiformats und des Kopierschutzes erfolgt erst im System des E-Book Anbieters
E-Book bestellen

Unsere Web-Seiten verwenden Cookies. Mit der Nutzung dieser Web-Seiten erklären Sie sich damit einverstanden. Mehr Informationen finden Sie in unserem Datenschutzhinweis. Ok