Drug Allergy Testing

 
 
Elsevier (Verlag)
  • 1. Auflage
  • |
  • erschienen am 5. Juli 2017
  • |
  • 250 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-323-49707-7 (ISBN)
 

With a focus on improving diagnosis and treatment, Drug Allergy Testing is your new go-to resource for understanding various drug allergies and testing methods, the epidemiology of and economic impact of drug allergies, and new drug and allergy developments.

  • Features a wealth of up-to-date information for allergists, immunologists, and primary care physicians who diagnose and treat patients with drug allergies and hypersensitivity.

  • Covers the basics of drug allergy evaluation and management as well as specific drugs including antibiotics, ASA/NSAIDs, chemotherapeutic agents and monoclonal antibodies.
  • Englisch
  • Philadelphia
  • |
  • USA
  • Höhe: 260 mm
  • |
  • Breite: 184 mm
  • |
  • Dicke: 0 mm
  • 4,72 MB
978-0-323-49707-7 (9780323497077)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Drug Allergy Testing
  • Drug Allergy Testing
  • Copyright
  • List of Contributors
  • Preface: Drug Allergy Testing
  • Contents
  • 1 - Epidemiology of Drug Allergy
  • DRUG HYPERSENSITIVITY REACTIONS
  • SEVERE CUTANEOUS ADVERSE REACTIONS
  • ANAPHYLAXIS
  • PEDIATRIC DRUG ALLERGY
  • LIMITATIONS IN DIAGNOSIS
  • RISK FACTORS
  • GENETICS
  • CONCLUSIONS
  • REFERENCES
  • 2 - Economic Impact of Drug Allergy
  • INTRODUCTION
  • COST OF ADVERSE DRUG REACTIONS, ADVERSE DRUG EVENTS, AND HYPERSENSITIVITY REACTIONS
  • Cost of Adverse Drug Events and Adverse Drug Reactions
  • Cost of Hypersensitivity Reactions
  • COSTS OF OVERREPORTING ALLERGIES
  • COST-EFFECTIVENESS ANALYSES IN DRUG HYPERSENSITIVITY
  • Genetic Screening in Drug Hypersensitivity
  • Aspirin Desensitization
  • SUMMARY
  • REFERENCES
  • 3 - Drug Allergy: Definitions and Phenotypes
  • DEFINITIONS
  • PHENOTYPING OF DRUG HYPERSENSITIVITY REACTIONS BY CHRONOLOGY
  • PHENOTYPING OF DRUG HYPERSENSITIVITY REACTIONS BY CLINICAL MANIFESTATIONS
  • Clinical Phenotypes Often Associated With Immediate (Acute) Drug Hypersensitivity Reactions and typical elicitors
  • Urticaria and angioedema
  • Anaphylaxis
  • Maculopapular exanthem
  • Symmetric drug-related intertriginous and flexural exanthem
  • Acute generalized exanthematous pustulosis
  • Bullous exanthems
  • Drug reaction with eosinophilia and systemic symptoms
  • Fixed drug eruption
  • Vasculitis
  • Organ-specific and miscellaneous drug reactions
  • Drug-induced autoimmune disease
  • REFERENCES
  • 4 - Immune Mechanisms of Drug Allergy
  • INTRODUCTION
  • Gell-Coombs Classification of Immune-Mediated Adverse Drug Reactions
  • THE IMMUNOPATHOGENESIS OF T CELL-MEDIATED DRUG HYPERSENSITIVITY SYNDROME: ESTABLISHED MODELS
  • Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
  • Drug Reaction With Eosinophilia and Systemic Symptoms
  • Drug-Specific Models: The Aromatic Amine Anticonvulsants
  • Drug-Specific Models: Allopurinol
  • Drug-Specific Models: Abacavir Hypersensitivity Syndrome
  • Unexplained Features of T Cell-Mediated Adverse Drug Reactions
  • FUTURE RESEARCH AND IMPLICATIONS FOR CLINICAL PRACTICE
  • ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 5 - Pharmacogenomics of Drug Allergy
  • INTRODUCTION
  • REACTIONS LACKING IMMUNOLOGIC MEMORY
  • Reactions With a Pharmacologic Component
  • Reactions With an Off-Target Pharmacologic and/or Immunologic Component
  • Non-IgE-mediated mast-cell activation
  • Aspirin exacerbated respiratory disease
  • Other NSAID reactions. Cutaneous hypersensitivities to aspirin and other NSAID drugs can be classified as per the European Acade...
  • Drug-induced thrombocytopenia
  • Heparin-induced thrombocytopenia. Heparin and related anticoagulants are associated with the development of heparin-induced thro...
  • REACTIONS INVOLVING IMMUNOLOGIC MEMORY
  • Immediate/Accelerated Immune-Mediated Reactions
  • Delayed Immune Reactions
  • Human leukocyte antigen
  • PHARMACOGENOMIC SCREENING
  • ACKNOWLEDGEMENT
  • REFERENCES
  • 6 - Cutaneous Reactions to Drugs
  • INTRODUCTION
  • LYMPHOCYTIC AND EOSINOPHILIC EXANTHEMS
  • Morbilliform Exanthem Versus Drug Hypersensitivity
  • Drug-Induced Lichenoid Eruptions
  • Symmetric Drug-Related Intertriginous and Flexural Exanthema
  • NEUTROPHILIC EXANTHEMS
  • Acute Generalized Exanthematous Pustulosis
  • Linear IgA Bullous Dermatosis
  • Drug-Induced Sweet Syndrome
  • URTICARIA, ANGIOEDEMA, AND ANAPHYLAXIS
  • DRUG-INDUCED VASCULITIC REACTIONS
  • SEVERE ADVERSE DRUG REACTIONS
  • Erythema Multiforme
  • Drug Reaction With Eosinophilia and Systemic Symptoms
  • Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
  • DRUG-INDUCED ACANTHOLYTIC DISORDERS
  • Pemphigus
  • Pemphigoid
  • OTHER ADVERSE DRUG REACTIONS
  • Fixed Drug Eruption
  • Acneiform Eruptions
  • Pigmentary Disorders
  • Nail Disorders
  • Noncicatricial Alopecia
  • Pruritus Without Rash
  • REFERENCES
  • 7 - Basics of Skin Testing and Drug Challenges
  • SKIN TESTING
  • Cephalosporin antibiotics
  • Monobactam antibiotics
  • Carbapenem antibiotics
  • Non-ß-Lactam Antibiotics
  • Macrolide antibiotics
  • Quinolone antibiotics
  • Sulfonamide antibiotics
  • Other antibiotics
  • Aspirin and Nonsteroidal Drugs
  • Chemotherapy Drugs
  • Biologics and Monoclonal Antibodies
  • Perioperative Drugs (Including Local Anesthetics)
  • Radiocontrast Media
  • Corticosteroids
  • Heparins
  • DRUG CHALLENGES
  • REFERENCES
  • 8 - In Vitro and In Vivo Tests for Drug Hypersensitivity Reactions
  • INTRODUCTION
  • SKIN TESTING
  • DRUG PROVOCATION TESTING
  • IN VITRO DIAGNOSTIC TESTING
  • MEDIATORS OF AN ALLERGIC REACTION
  • Measuring Histamine and Histamine Metabolites
  • Serum Tryptase
  • IN VITRO TESTING FOR SPECIFIC IGE-MEDIATED AND NON-IGE-MEDIATED REACTIONS
  • Mediator Release Assays (Histamine and CysLTs)
  • Basophil Activation Test
  • ASSESSING T CELL-MEDIATED DRUG ALLERGY
  • Patch Testing
  • Intracutaneous Testing With Delayed Readings
  • Human Leukocyte Antigen Typing for Drug Hypersensitivity Screening
  • Lymphocyte Transformation Testing
  • Enzyme-Linked Immunosorbent Spot Assays
  • Combining Tests to Increase Sensitivity
  • SKIN BIOPSY
  • CONCLUSION
  • ABBREVIATIONS
  • CONFLICT OF INTEREST
  • REFERENCES
  • 9 - Drug Desensitization
  • POSSIBLE MECHANISMS
  • DESENSITIZATION PROCESS
  • PRETREATMENT
  • BREAKTHROUGH REACTIONS DURING DESENSITIZATION
  • OUTCOMES
  • REFERENCES
  • 10 - Penicillins
  • INTRODUCTION
  • THE EARLY PENICILLIN HYPERSENSITIVITY OBSERVATIONS
  • PENICILLIN SPECIFIC T CELLS RESPONSIBLE FOR DELAYED-ONSET PENICILLIN HYPERSENSITIVITY
  • ANTIPENICILLIN IGG AND SERUM SICKNESS-LIKE REACTIONS
  • OTHER SERIOUS PENICILLIN-ASSOCIATED ADVERSE REACTIONS
  • WHY PENICILLIN "ALLERGY" IS STILL SO COMMON
  • PENICILLIN BIOCHEMISTRY AND EARLY PENICILLIN SKIN TEST STUDIES
  • PENICILLIN ALLERGY TESTING TODAY
  • THE SAFETY AND CURRENT INDICATIONS FOR A DIRECT ORAL CHALLENGE TO VERIFY ACUTE PENICILLIN TOLERANCE
  • PENICILLIN SKIN TESTING BEFORE ORAL CHALLENGE
  • Adverse Reactions Associated With Penicillin Skin Testing
  • COMMERCIALLY AVAILABLE ANTIPENICILLIN IGE BLOOD ALLERGY TESTS ARE NOT CURRENTLY CLINICALLY USEFUL
  • RESENSITIZATION
  • DESENSITIZATION
  • CONCLUSIONS
  • REFERENCES
  • 11 - Cephalosporin Allergy
  • INTRODUCTION
  • CEPHALOSPORIN ALLERGENIC DETERMINANTS
  • CLINICAL MANIFESTATIONS
  • Immediate Reactions
  • Nonimmediate Reactions
  • DIAGNOSIS
  • Clinical History
  • Immediate Reactions
  • In vitro tests
  • Drug provocation tests
  • In vitro tests
  • ADMINISTRATION OF ALTERNATIVE ?-LACTAMS, INCLUDING CEPHALOSPORINS, IN SUBJECTS ALLERGIC TO CEPHALOSPORINS
  • ABBREVIATIONS
  • REFERENCES
  • 12 - Macrolide Allergy
  • INTRODUCTION
  • CLINICAL MANIFESTATIONS
  • IMMEDIATE REACTIONS
  • NONIMMEDIATE REACTIONS
  • Maculopapular Exanthema
  • Allergic Contact Dermatitis
  • Fixed Drug Eruption
  • Acute Generalized Exanthematous Pustulosis
  • Symmetric Drug-Related Intertriginous and Flexural Exanthema
  • Drug Reaction With Eosinophilia and Systemic Symptoms
  • Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
  • Eosinophilic Pneumonia
  • Vasculitic Syndromes
  • DIAGNOSIS
  • SKIN TESTING
  • PATCH TESTING
  • IN VITRO TESTING FOR SPECIFIC IGE
  • OTHER FORMS OF IN VITRO TESTING
  • DRUG PROVOCATION TESTING
  • History of Delayed Reactions
  • DESENSITIZATION PROTOCOLS
  • CROSS-REACTIVITY
  • HYPERSENSITIVITY REACTIONS TO IMMUNOSUPPRESSANT MACROLIDES
  • CONCLUSION
  • REFERENCES
  • 13 - Quinolone Allergy
  • INTRODUCTION
  • CLASSIFICATION AND CHEMICAL STRUCTURE
  • EPIDEMIOLOGY AND RISK FACTORS
  • CLINICAL SYMPTOMS
  • Immediate Reactions
  • Delayed Reactions
  • DIAGNOSIS
  • Clinical History
  • Skin Tests
  • In vitro tests
  • Drug provocation test
  • CROSS-REACTIVITY
  • MANAGEMENT
  • CONCLUSIONS
  • CONFLICT OF INTEREST
  • FUNDING
  • REFERENCES
  • 14 - Sulfonamide Drug Allergy
  • INTRODUCTION
  • TERMINOLOGY AND CLASSIFICATION
  • Sulfonamide
  • Sulfonamide Antibiotics
  • Sulfonamide Nonantibiotics
  • MECHANISMS OF REACTIONS TO SULFONAMIDE ANTIBIOTICS
  • Metabolism
  • Cellular Mechanisms
  • Humoral Mechanisms
  • Reactions in HIV
  • Hypersensitivity to Trimethoprim
  • APPROACH TO THE PATIENT
  • Types of Reactions to Sulfonamide Antibiotics
  • Types of Reactions in HIV
  • Adverse Effects
  • CLINICAL EVALUATION
  • History
  • Physical Examination
  • Laboratory Testing
  • Diagnostic Testing
  • CROSS-REACTIVITY
  • Cross-reactivity Among Sulfonamide Antibiotics
  • Cross-reactivity Between Sulfonamide Antibiotics and Nonantibiotics
  • SULFONAMIDE-NONANTIBIOTIC HYPERSENSITIVITY
  • Loop Diuretics
  • Thiazide Diuretics
  • Sulfonylureas
  • COX-2 Inhibitors
  • Sulfasalazine
  • Protease Inhibitors
  • Dapsone
  • Carboxy Anhydrase Inhibitors
  • 5-HT Agonists
  • MANAGEMENT
  • Desensitization
  • TMP-SMX Desensitization in HIV Negative Patients
  • Trimethoprim-Sulfamethoxazole Desensitization in HIV Positive Patients
  • CONCLUSION
  • REFERENCES
  • 15 - Other Antibiotic Allergy
  • INTRODUCTION
  • VANCOMYCIN
  • Red Man Syndrome
  • Linear IgA Bullous Dermatosis
  • Other Adverse Reactions
  • METRONIDAZOLE
  • TETRACYCLINES
  • DAPSONE
  • CLINDAMYCIN
  • AMINOGLYCOSIDES
  • REFERENCES
  • 16 - Multiple Drug Intolerance Syndrome
  • INTRODUCTION
  • EPIDEMIOLOGY
  • TRUE IMMUNOLOGICALLY MEDIATED MULTIPLE DRUG INTOLERANCE
  • RISK FACTORS FOR MULTIPLE DRUG INTOLERANCE
  • CLINICAL MANAGEMENT OF TYPICAL CASES
  • DRUG CHALLENGES
  • CONCLUSIONS
  • REFERENCES
  • 17 - Aspirin-Exacerbated Respiratory Disease
  • INTRODUCTION
  • Definition and Classification
  • Prevalence
  • DIAGNOSIS BASED ON CLINICAL HISTORY
  • DIAGNOSTIC TESTING WITH PROVOCATION CHALLENGES
  • Safety Requirements and Circumstances for Performing Provocation Challenges
  • Oral Aspirin Challenge
  • Intranasal Challenge With Ketorolac
  • IN VITRO DIAGNOSIS
  • SUMMARY
  • REFERENCES
  • 18 - Other NSAIDs Reactions
  • INTRODUCTION
  • CLASSIFICATION AND MECHANISMS
  • EPIDEMIOLOGY
  • TYPES OF NSAIDS IN SPECIFIC NSAID HYPERSENSITIVITY PHENOTYPES
  • PHENOTYPES OF NSAID HYPERSENSITIVITY
  • NSAID-Exacerbated Cutaneous Disease
  • NSAID-Induced Urticaria and Angioedema
  • Single NSAID-Induced Urticaria, Angioedema, and Anaphylaxis
  • Single NSAID-Induced Delayed Reactions
  • Maculopapular exanthema
  • Fixed drug eruption
  • Acute generalized exanthematous pustulosis
  • Drug rash with eosinophilia and systemic symptoms
  • Stevens-Johnson syndrome/toxic epidermal necrolysis
  • Contact dermatitis and photoallergic dermatitis
  • MIXED REACTIONS
  • COFACTORS, RISK FACTORS, AND ATOPY
  • NATURAL HISTORY OF NSAID HYPERSENSITIVITY
  • DIAGNOSIS
  • In Vivo Tests
  • In Vitro Tests
  • Drug Provocation Tests
  • CHALLENGE WITH ALTERNATIVE DRUGS
  • DESENSITIZATION
  • REFERENCES
  • 19 - Chemotherapy Allergy
  • INTRODUCTION
  • PLATIN HYPERSENSITIVITY
  • TAXANES HYPERSENSITIVITY
  • EVALUATION OF PATIENTS WITH HYPERSENSITIVITY REACTIONS TO CHEMOTHERAPY
  • PREMEDICATIONS AND PROTOCOLS FOR RAPID DRUG DESENSITIZATION FOR CHEMOTHERAPY
  • OUTCOMES OF RAPID DRUG DESENSITIZATION FOR CHEMOTHERAPY AND MONOCLONAL ANTIBODIES
  • CONCLUSION
  • REFERENCES
  • 20 - Hypersensitivity Reactions to Monoclonal Antibodies
  • BASICS OF MAB PRODUCTION
  • IMMUNOGENICITY
  • CLASSIFICATION OF ADVERSE REACTIONS TO MABS
  • INFUSION REACTIONS
  • RITUXIMAB
  • CETUXIMAB
  • OMALIZUMAB
  • MANAGEMENT
  • DIAGNOSTIC TESTING
  • DESENSITIZATION
  • CONCLUSIONS
  • ABBREVIATIONS
  • REFERENCES
  • 21 - Perioperative Allergy
  • INTRODUCTION
  • INCIDENCE
  • DEFINITION OF TERMS AND CLASSIFICATION
  • MECHANISMS AND DIFFERENTIAL DIAGNOSES
  • CLINICAL PRESENTATION AND MANAGEMENT IN THE OPERATING ROOM
  • ALLERGY EVALUATION
  • Serum Tryptase
  • Specific IgE
  • Basophil Histamine Release and Basophil Activation Tests
  • Skin Testing
  • Drug Provocation
  • CAUSES
  • Anesthetic Agents
  • Local Anesthetics
  • Opioids and Other Analgesics
  • Neuromuscular Blocking Agents
  • Reversal Agents
  • Antibiotics
  • Plasma Expanders
  • Blood and Blood Products
  • "Hidden Allergens"-Substances Not Administered IV and Not Always Documented on Charts
  • Latex
  • Disinfectants
  • Sterilizing Agents
  • Blue Dyes
  • Oxytocin
  • Other Hidden Exposures in the Perioperative Setting
  • ABBREVIATIONS
  • REFERENCES
  • 22 - Adverse Reactions to Contrast Media
  • INTRODUCTION
  • IODINATED CONTRAST MEDIA
  • Types of Iodinated Contrast Media
  • Types of Adverse Reactions
  • Epidemiology
  • Diagnostic Testing
  • Prevention of Immediate Hypersensitivity Reactions
  • Approach to High-Risk Patients
  • Management of Acute Reactions
  • GADOLINIUM-BASED CONTRAST MEDIA
  • Types of Gadolinium-Based Contrast Media
  • Types of Adverse Reactions, Frequency, and Management
  • REFERENCES
  • 23 - Corticosteroids
  • INTRODUCTION
  • IMMEDIATE HYPERSENSITIVITY REACTIONS
  • Skin Testing for Corticosteroids
  • Succinate ester
  • Lactose
  • Carboxymethylcellulose
  • Polyethylene glycol
  • Summary and Recommendations for Immediate Hypersensitivity Reactions
  • CONTACT DERMATITIS
  • Structure and Cross-Reactivity
  • Patch Testing
  • Summary and Recommendations for Contact Dermatitis
  • REFERENCES
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W

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