Computational Biology

A Hypertextbook
 
 
ASM Press
  • 1. Auflage
  • |
  • erschienen am 6. August 2020
  • |
  • 210 Seiten
 
E-Book | PDF mit Adobe-DRM | Systemvoraussetzungen
978-1-68367-003-2 (ISBN)
 
An introduction to the world of bioinformatics

Massive increases in computing power and the ability to routinely sequence whole genomes of living organisms have begun to fundamentally alter our understanding of biology, medicine, and agriculture. At the intersection of the growing information and genomics revolutions sits bioinformatics, which uses modern computational power to reveal patterns in biological data sets, especially DNA, RNA, and protein sequences.

Computational Biology: A Hypertextbook, by Scott Kelley and Dennis Didulo, provides a wonderful introduction for anyone who wants to learn the basics of bioinformatics. This book is more than a textbook because of the wealth of online ancillary materials and how the print and electronic components are integrated to form a complete educational resource. Aspects that make Computational Biology: A Hypertextbook a unique and valuable tool for teaching and learning bioinformatics include
* Clear explanations of the basic biology of DNA, RNA, and proteins and how the related bioinformatics algorithms work
* Extensive exercises that enable students to practice with the same bioinformatics applications that are used by scientists worldwide
* Tutorials, sample data sets, and interactive learning tools developed with teachers in mind and field-tested by hundreds of students
* Online tutorials and curated web links that are accurate (instead of frustrating!) and won't lead to dead ends
* Online resources that work on multiple platforms and electronic devices

Computational Biology: A Hypertextbook is written in an accessible voice, punctuated with humor, and designed to significantly increase computational competencies. Biology and computer science undergraduate and graduate students will thoroughly enjoy learning from this unique hypertextbook, as will anyone with an interest in exploring this burgeoning topic.
1. Auflage
  • Englisch
  • USA
  • Für Beruf und Forschung
  • 31,95 MB
978-1-68367-003-2 (9781683670032)
weitere Ausgaben werden ermittelt
Scott T. Kelley is a professor of biology at San Diego State University. He received his doctoral degree from the University of Colorado and his bachelor's degree from Cornell University. His lab uses phylogenetic methods and culture-independent molecular tools to study environmental microbiology, and Kelley has published extensively on the human microbiome, built environment, and numerous natural environments.

Dennis Didulo is a data analytics and software engineer working at Becton, Dickinson and Company. He received his master's degree in information technology at De La Salle University and his second master's degree in bioinformatics at San Diego State University. He has development expertise in more than a dozen computer languages, as well as in database management, algorithm design, and systems engineering.
Preface ix

For the Instructor xi

For the Student xiii

Acknowledgments xiv

About the Authors xv

Chapter -1 Getting Started 1

Chapter 00 Introduction 5

Activity 0.1: Biological Databases and Data Storage 20

Chapter 01 BLAST 31

Activity 1.1: BLAST Algorithm 36

Chapter 02 Protein Analysis 47

Activity 2.1: Hydrophobicity Plotting 52

Activity 2.2: Protein Secondary Structure Prediction 58

Chapter 03 Sequence Alignment 67

Activity 3.1: Dynamic Programming 74

Chapter 04 Patterns in the Data 91

Activity 4.1: Protein Sequence Motifs 94

Activity 4.2: Position-Specific Weight Matrices 102

Chapter 05 RNA Structure Prediction 111

Activity 5.1: RNA Structure Prediction 118

Chapter 06 Phylogenetics 133

Activity 6.1: Phylogenetic Analysis 140

Chapter 07 Probability: All Mutations are not Equal (-ly Probable) 157

Activity 7.1: Generating PAM and BLOSUM Substitution Matrices 163

Chapter 08 Bioinformatics Programming: A Primer 179

Index 191

Dateiformat: PDF
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat PDF zeigt auf jeder Hardware eine Buchseite stets identisch an. Daher ist eine PDF auch für ein komplexes Layout geeignet, wie es bei Lehr- und Fachbüchern verwendet wird (Bilder, Tabellen, Spalten, Fußnoten). Bei kleinen Displays von E-Readern oder Smartphones sind PDF leider eher nervig, weil zu viel Scrollen notwendig ist. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Bitte beachten Sie bei der Verwendung der Lese-Software Adobe Digital Editions: wir empfehlen Ihnen unbedingt nach Installation der Lese-Software diese mit Ihrer persönlichen Adobe-ID zu autorisieren!

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Download (sofort verfügbar)

69,99 €
inkl. 5% MwSt.
Download / Einzel-Lizenz
PDF mit Adobe-DRM
siehe Systemvoraussetzungen
E-Book bestellen