This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
1 Introduction.- References.- 2 Nomenclature.- References .- 3 Syntheses.- 3.1 Syntheses of acridine ring and its precursors.- 3.2 Acridine-peptide conjugates .- 3.3 Acridines as catalysts.- References.- 4.- Interactions of acridines with nucleic acids .- 4.1 DNA.- 4.2 DNA Quadruplexes.- 4.3 RNA.- 4.4 PNA .- 4.5 Acridine metal complexes.- 4.6 Structural aspects of nucleic acid binding.- References.- 5 Interactions with proteins.- 5.1 Interactions with nucleic acids processing proteins.- 5.1.1 Topoisomerases .- 5.1.2 Transcription factors.- 5.1.3 RecA protein.- 5.1.4 Telomerase.- 5.2 Interactions with other proteins.- 5.3 Structural aspects of acridine interactions with proteins.- References.- 6 Applications for treatment of neurodegenerative diseases.- 6.1 Alzheimer's disease.- 6.1.1 Multitargeted strategy in AD.- 6.2 Parkinson's disease.- 6.3 Prion diseases.- 6.4 Other neurodegenerative diseases.- References.- 7 Some application of selective toxicities of acridines.- 7.1 Antiprotozoal drug.- 7.2 Cancer treatment.- 7.3 Antibacterial drug.- 7.4 Pharmacokinetics and metabolism of acridine drugs.- References.- 8 Acridine on dendrimeric carriers.- 8.1 Application for drug and gene delivery.- References.- 9 Acridines used for staining.- References.- 10 Miscellaneous.- References.- 11 Conclusions and outlook