Gut-Brain Axis

Dietary, Probiotic, and Prebiotic Interventions on the Microbiota
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 13. Mai 2016
  • |
  • 508 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-802544-4 (ISBN)
 

The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota examines the potential for microbial manipulation as a therapeutic avenue in central nervous system disorders in which an altered microbiota has been implicated, and explores the mechanisms, sometimes common, by which the microbiota may contribute to such disorders.


  • Focuses on specific areas in which the microbiota has been implicated in gut-brain communication
  • Examines common mechanisms and pathways by which the microbiota may influence brain and behavior
  • Identifies novel therapeutic strategies targeted toward the microbiota in the management of brain activity and behavior
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 6,13 MB
978-0-12-802544-4 (9780128025444)
0128025441 (0128025441)
weitere Ausgaben werden ermittelt
  • Front Cover
  • The Gut-Brain Axis
  • The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota
  • Copyright
  • Contents
  • List of Contributors
  • Preface
  • 1 - Regulatory Considerations for the Use and Marketing of Probiotics and Functional Foods
  • REGULATORY IMPACT OF DEFINITIONS
  • GUT-BRAIN AXIS: WHAT COULD BE RELEVANT FOR ESTABLISHING REGULATIONS?
  • CONCLUSIONS
  • REFERENCES
  • 2 - Targeting the Microbiota: Considerations for Developing Probiotics as Functional Foods
  • THE PROBIOTIC CONCEPT AND EVOLUTION
  • FUNCTIONAL FOOD VERSUS FOODS BEARING NUTRITIONAL OR HEALTH CLAIMS
  • CRITERIA FOR DEVELOPING PROBIOTICS AND CLAIMING THEIR BENEFITS ON FOODS IN EUROPE
  • CHARACTERIZATION OF THE FOOD (CONSTITUENT)
  • DEFINITION OF THE HEALTH CLAIM AND RELEVANCE TO HUMAN HEALTH
  • SUBSTANTIATION OF THE HEALTH CLAIM
  • SITUATION OF CLAIMS ON PROBIOTIC PRODUCTS IN DIFFERENT COUNTRIES
  • FUTURE PERSPECTIVES IN THE DEVELOPMENT OF PROBIOTICS
  • CONCLUSIONS
  • ACKNOWLEDGMENT
  • REFERENCES
  • 3 - Perspectives on Microbiome Manipulation in People of Developing Countries
  • MICROBIOME NUANCES
  • FERMENTED FOODS AND PROBIOTICS FOR HEALTH
  • CONCLUSIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 4 - Value of Microbial Genome Sequencing for Probiotic Strain Identification and Characterization: Promises and Pitfalls
  • INTRODUCTION
  • PROBIOTIC SELECTION AND IDENTIFICATION
  • TAXONOMIC IDENTIFICATION
  • NEXT-GENERATION SEQUENCING TOOLS
  • ROCHE/454 LIFE SCIENCES
  • ILLUMINA
  • LIFE TECHNOLOGIES
  • THIRD-GENERATION DNA SEQUENCERS
  • FROM SEQUENCE TO FUNCTION
  • PROBIOTIC SAFETY ASSESSMENTS USING GENOMIC DATA
  • PROBIOGENOMICS
  • CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 5 - Probiotics as Curators of a Healthy Gut Microbiota: Delivering the Solution
  • INTRODUCTION
  • GUT MICROBIOTA COMPOSITION IN INFANTS AND ADULTS
  • FACTORS DISRUPTING THE GUT MICROBIOTA
  • PREBIOTICS AND PROBIOTICS
  • POTENTIAL BENEFITS OF PREBIOTICS AND PROBIOTICS
  • DELIVERY OF VIABLE AND FUNCTIONAL PROBIOTICS
  • NONFOOD-BASED PROBIOTIC DELIVERY
  • FOOD-BASED PROBIOTIC DELIVERY
  • Yogurt
  • Ice Cream and Desserts
  • Cheese
  • Beverages and Other Probiotic Foods
  • GUT MICROBIOTA MODULATION USING PROBIOTICS AND PREBIOTICS
  • INFANT MICROBIOTA MODULATION
  • ADULT MICROBIOTA MODULATION
  • CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 6 - Microbial Endocrinology: Context and Considerations for Probiotic Selection
  • HISTORICAL CONTEXT
  • MICROBIAL ENDOCRINOLOGY: RELEVANCE TO PROBIOTICS
  • CONCEPTUAL BASIS
  • PROBIOTIC MICROORGANISMS KNOWN TO PRODUCE NEUROCHEMICALS
  • ESCHERICHIA
  • LACTOBACILLI
  • SACCHAROMYCES
  • OTHER BACTERIAL GENERA
  • EXPERIMENTAL ISSUES ASSOCIATED WITH EVALUATION OF PROBIOTICS FOR NEUROCHEMICAL PRODUCTION
  • IN VITRO TESTING ISSUES
  • EXPERIMENTAL RUBRIC TO ADDRESS IN VITRO TO IN VIVO DESIGN ISSUES
  • DIETARY ISSUES
  • CONCLUDING THOUGHTS
  • REFERENCES
  • 7 - Germ-Free Animals: A Key Tool in Unraveling How the Microbiota Affects the Brain and Behavior
  • INTRODUCTION
  • COMMUNICATION ALONG THE MICROBIOTA-GUT-BRAIN AXIS
  • THE MICROBIOTA-BRAIN-GUT AXIS IN HEALTH AND DISEASE
  • THE GERM-FREE MOUSE
  • THE GERM-FREE MOUSE AND HEALTH
  • AGING
  • IMMUNE STATUS
  • METABOLISM AND DIGESTION
  • GASTROINTESTINAL HEALTH
  • ENTERIC NERVOUS SYSTEM FUNCTION
  • GNOTOBIOTICS, HUMANIZATION, AND FECAL MICROBIAL THERAPY
  • ANXIETY AND STRESS RESPONSIVITY
  • ALTERATIONS IN HPA FUNCTION
  • ALTERATIONS IN STRESS CIRCUITRY
  • ALTERATIONS IN ANXIETY BEHAVIOR
  • SOCIAL, REPETITIVE, AND LOCOMOTOR BEHAVIORS
  • SOCIAL BEHAVIOR IN GERM-FREE MICE
  • REPETITIVE AND LOCOMOTOR BEHAVIOR IN GERM-FREE MICE
  • PARALLELS TO AUTISM SPECTRUM DISORDERS
  • LEARNING AND MEMORY
  • NEUROCHEMICAL AND MOLECULAR ALTERATIONS
  • SEROTONERGIC SYSTEM
  • SYNAPSE-RELATED TRANSCRIPTOMIC ALTERATIONS
  • BRAIN-DERIVED NEUROTROPHIC FACTOR
  • NEUROGENESIS
  • BLOOD-BRAIN BARRIER
  • MICROGLIA
  • THE GERM-FREE MOUSE: STRENGTHS, LIMITATIONS, AND ALTERNATIVES
  • CONCLUSIONS
  • REFERENCES
  • 8 - Global and Epidemiological Perspectives on Diet and Mood
  • CHANGES TO THE FOOD SUPPLY AND GLOBAL IMPACT ON HEALTH
  • NUTRIENTS AND MENTAL HEALTH
  • DIET QUALITY
  • INTERVENTION STUDIES
  • CLINICAL APPLICATIONS
  • REFERENCES
  • 9 - Importance of the Microbiota in Early Life and Influence on Future Health
  • INTRODUCTION
  • THE DEVELOPING MICROBIOTA IN EARLY LIFE
  • PRENATAL MICROBIOTA COLONIZATION
  • FACTORS AFFECTING POSTNATAL MICROBIAL COLONIZATION
  • ENVIRONMENTAL INFLUENCES ON EARLY LIFE MICROBIOTA
  • Nutrition
  • Stress
  • Early Life Antibiotic Use and Germ-Free Environment
  • IMPACT OF EARLY LIFE MICROBIOTA ON THE DEVELOPMENT OF KEY HOST HOMEOSTATIC MECHANISMS
  • HOW IS INTESTINAL BARRIER DEVELOPMENT SHAPED BY THE MICROBIOTA?
  • IMMUNE DEVELOPMENT
  • DEVELOPMENT OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND STRESS RESPONSE
  • HEALTH OUTCOMES RELATED TO PERTURBATION OF THE INTESTINAL MICROBIOTA IN EARLY LIFE
  • DISORDERS OF THE GUT
  • Inflammatory Bowel Disease
  • Celiac Disease
  • DISORDERS OF THE BRAIN AND NERVOUS SYSTEM
  • Anxiety and Depression
  • Obesity
  • Autism Spectrum Disorders
  • CONCLUDING REMARKS
  • REFERENCES
  • 10 - The Microbiome in Aging: Impact on Health and Wellbeing
  • INTRODUCTION
  • GENERAL FEATURES OF THE MICROBIOTA
  • MICROBIOTA THROUGHOUT LIFE
  • MICROBIOME RICHNESS
  • HOW HABITUAL DIET MODULATES MICROBIOTA DIVERSITY
  • MICROBIOTA IN THE ELDERLY
  • CHANGES DURING AGING
  • IMMUNOSENESCENCE AND INFLAMM-AGING
  • MICROBIOME COMPOSITION IN THE ELDERLY
  • PRESSURES ON THE AGING MICROBIOME
  • PROBIOTICS, PREBIOTICS AND OTHER MODULATORS OF THE MICROBES IN THE ELDERLY
  • FUTURE PERSPECTIVES
  • REFERENCES
  • 11 - Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis
  • INTRODUCTION
  • ANTIBIOTICS USE AMONG PERSONS WITH CYSTIC FIBROSIS
  • THE MODULATORY EFFECTS OF SPECIFIC ANTIBIOTICS ON THE GUT MICROBIOTA (NON-CYSTIC FIBROSIS HOSTS)
  • Macrolides
  • ß-Lactams
  • Lincosamides
  • Fluoroquinolones
  • Polmyxins
  • Nitrimidazoles
  • Glycopeptides
  • Effects of Combination Therapy on Gut Microbiota
  • LONG-TERM ISSUES OF CHRONIC ANTIBIOTIC USE
  • MULTIDRUG RESISTANCE
  • Development of Opportunistic Pathogens and Antibiotic-Associated Diarrhea
  • Interference of Mutualistic Host-Microbe Interactions through Antibiotic-Induced Alteration of Gut Microbiome
  • MODULATION OF THE GUT MICROBIOTA
  • DIET
  • Positive Modulation of the Gut Microbiota
  • FUTURE DIRECTIONS
  • CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 12 - Correlating the Gut Microbiome to Health and Disease
  • INTRODUCTION
  • GUT MICROBIOTA AND IMMUNE SYSTEM-RELATED DISEASES
  • ALLERGIES AND ASTHMA
  • RHEUMATOID ARTHRITIS
  • GUT MICROBIOTA AND INTESTINAL DISEASES
  • RECURRENT CLOSTRIDIUM DIFFICILE INFECTIONS
  • INFLAMMATORY BOWEL DISEASE
  • IRRITABLE BOWEL SYNDROME
  • COLORECTAL CANCER
  • GUT MICROBIOTA AND DISEASES OF THE NERVOUS SYSTEM
  • ANXIETY AND DEPRESSION
  • AUTISTIC SPECTRUM DISORDER
  • ALZHEIMER'S DISEASE
  • PARKINSON'S DISEASE
  • GUT MICROBIOTA AND METABOLIC DISEASES
  • OBESITY
  • TYPE II DIABETES
  • NONALCOHOLIC FATTY LIVER DISEASE
  • OVERVIEW OF SOME POTENTIAL THERAPIES THAT ARE CURRENTLY BEING USED TO RE-ESTABLISH A HEALTHY GUT MICROBIOTA
  • CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 13 - The Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota: A Target for Dietary Intervention?
  • INTRODUCTION
  • THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
  • GUT MICROBIOTA: A CRITICAL FACTOR FOR DETERMINING THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS SETPOINT
  • ANTISTRESS EFFECTS OF PROBIOTICS
  • PATHWAYS, MOLECULES, AND CELL TYPES INVOLVED IN MICROBIOTA-GUT-BRAIN SIGNALING
  • AFFERENT NEURAL SIGNALING
  • SHORT-CHAIN FATTY ACIDS
  • MOLECULAR AND CELLULAR TARGETS INFLUENCED BY THE MICROBIOTA, PROBIOTICS, AND SHORT-CHAIN FATTY ACIDS
  • LEAKY GUT AND BLOOD-BRAIN BARRIER PERMEABILITY
  • MICROGLIA
  • EPIGENETICS
  • PROBIOTICS, PREBIOTICS, AND STRESS-RELATED DISORDERS
  • CONCLUSION AND PERSPECTIVES
  • REFERENCES
  • 14 - A Role for the Microbiota in Neurodevelopmental Disorders
  • INTRODUCTION
  • AUTISM SPECTRUM DISORDER
  • GASTROINTESTINAL DYSFUNCTION IN AUTISM SPECTRUM DISORDER
  • MICROBIAL DYSBIOSIS IN AUTISM SPECTRUM DISORDER
  • PROBIOTICS IN THE TREATMENT OF NEURODEVELOPMENTAL DISORDERS
  • OTHER MICROBIOTA-RELATED TREATMENTS FOR AUTISM SPECTRUM DISORDER
  • FUTURE STUDIES
  • REFERENCES
  • 15 - Altering the Gut Microbiome for Cognitive Benefit?
  • INTRODUCTION
  • FACTORS INFLUENCING COGNITION
  • DIETARY FACTORS
  • Breastfeeding and Bacterial Colonization
  • High-Fat Diet and Obesity
  • Depression
  • Serotonin
  • Inflammation and Infection
  • Aging
  • PROBIOTIC INTERVENTIONS AND COGNITIVE FUNCTION
  • PROBIOTIC INTERVENTION IN A HEALTHY CONTEXT
  • PROBIOTICS AND COGNITION IN THE CONTEXT OF DISEASE
  • INFLAMMATION AND INFECTION
  • METABOLIC DISORDERS
  • SCHIZOPHRENIA
  • PREBIOTIC INTERVENTION AND COGNITIVE FUNCTION
  • CONCLUSIONS
  • REFERENCES
  • 16 - The Influence of Diet and the Gut Microbiota in Schizophrenia
  • INTRODUCTION
  • GUT-BRAIN PATHWAYS IN SCHIZOPHRENIA
  • NEURODEVELOPMENT
  • BRAIN-DERIVED NEUROTROPHIC FACTOR
  • SEROTONIN
  • N-METHYL-D-ASPARTATE
  • INFLAMMATION AND IMMUNITY IN SCHIZOPHRENIA
  • GUT BARRIER DYSFUNCTION
  • INFECTION
  • AUTOIMMUNITY
  • DIET AND SCHIZOPHRENIA
  • GLUTEN SENSITIVITY
  • BOVINE CASEIN SENSITIVITY
  • METABOLIC DYSFUNCTION AND SCHIZOPHRENIA
  • HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
  • MICROBIOTA-GUT-BRAIN INTERVENTIONS IN SCHIZOPHRENIA
  • DIET
  • ANTIMICROBIALS
  • PREBIOTICS
  • PROBIOTICS
  • FECAL MICROBIAL TRANSPLANTATION
  • SUMMARY
  • REFERENCES
  • 17 - Alcohol-Dependence and the Microbiota-Gut-Brain Axis
  • ALCOHOL AND GUT BARRIER FUNCTION: WHAT HAVE ANIMAL AND HUMAN STUDIES TAUGHT US?
  • ALCOHOL, TIGHT JUNCTION FUNCTION, AND GUT PERMEABILITY
  • MOLECULAR MECHANISMS UNDERLYING ALCOHOL-INDUCED DISRUPTION OF THE GUT BARRIER
  • EFFECTS OF ALCOHOL ON THE GUT MUCUS LAYER
  • ALCOHOL-INDUCED CHANGES ON THE GUT MICROBIOTA
  • GUT MICROBIOTA-DERIVED METABOLITES
  • EFFECT OF ETHANOL ON GUT MICROBIOTA COMPOSITION
  • MICROBIOTA-DERIVED METABOLITES, GUT PERMEABILITY, AND ALCOHOL DEPENDENCE
  • CONTRIBUTION OF GENETIC AND ENVIRONMENTAL FACTORS TO ALCOHOL-ASSOCIATED DYSBIOSIS
  • DO CHANGES IN THE GUT INFLUENCE BRAIN AND BEHAVIOR IN ALCOHOL USE DISORDERS?
  • PSYCHOLOGICAL AND BEHAVIORAL CHANGES IN ALCOHOL DEPENDENCE
  • THE SICKNESS BEHAVIOR THEORY AND SYMPTOMS ASSOCIATED WITH ALCOHOL DEPENDENCE
  • NEUROINFLAMMATION AND ALCOHOL DEPENDENCE
  • DYSBIOSIS AND THE COMPLEXITY OF SYMPTOMS IN ALCOHOL USE DISORDERS
  • CONCLUSION
  • REFERENCES
  • 18 - Gut Microbiota and Metabolism
  • INTRODUCTION
  • GUT MICROBIOTA COMPOSITION AND METABOLIC DISORDERS
  • DYSBIOSIS ASSOCIATED WITH METABOLIC DISORDERS
  • PREBIOTIC AND PROBIOTIC AS TOOLS TO MODULATE DYSBIOSIS IN METABOLIC DISEASES
  • GUT MICROBIOTA, OBESITY, AND BEHAVIOR: THE MODULATION OF THE GUT ENDOCRINE FUNCTION AS A KEY TARGET
  • CONCLUSIONS
  • REFERENCES
  • 19 - Influence of the Microbiota on the Development and Function of the "Second Brain"-The Enteric Nervous System
  • INTRODUCTION
  • DEVELOPMENT OF THE ENTERIC NERVOUS SYSTEM
  • PRENATAL DEVELOPMENT OF THE ENTERIC NERVOUS SYSTEM
  • POSTNATAL DEVELOPMENT OF THE ENTERIC NERVOUS SYSTEM
  • MICROBIAL COLONIZATION OF THE GASTROINTESTINAL TRACT
  • INFLUENCE OF MICROBIOTA ON THE DEVELOPMENT OF THE ENTERIC NERVOUS SYSTEM
  • PROPOSED MECHANISMS FOR MICROBIAL-ENTERIC NERVOUS SYSTEM INTERACTIONS
  • POTENTIAL FOR PROBIOTIC THERAPY TO INFLUENCE THE ENS
  • CLINICAL RELEVANCE
  • CONCLUSIONS
  • REFERENCES
  • 20 - Dietary Interventions and Irritable Bowel Syndrome
  • INTRODUCTION
  • DIET, THE MICROBIOME, AND IRRITABLE BOWEL SYNDROME
  • PROBIOTICS IN IRRITABLE BOWEL SYNDROME
  • A SCIENTIFIC BASIS FOR THE USE OF PROBIOTICS IN IRRITABLE BOWEL SYNDROME
  • CLINICAL EVIDENCE OF EFFICACY OF PROBIOTICS IN IRRITABLE BOWEL SYNDROME
  • PREBIOTICS
  • CONCLUSION
  • REFERENCES
  • 21 - The Role of the Microbiota and Potential for Dietary Intervention in Chronic Fatigue Syndrome
  • INTRODUCTION
  • HUMAN GUT MICROBIOTA
  • COMPOSITION
  • DYSBIOSIS OF THE GUT MICROBIOTA
  • DYSBIOSIS IN CHRONIC FATIGUE SYNDROME
  • PROBIOTICS IN CHRONIC FATIGUE SYNDROME
  • DYSBIOSIS IN CHRONIC FATIGUE SYNDROME: POSSIBLE CAUSES AND CONSEQUENCES
  • Bacterial and Viral Infections
  • Impaired Mucosal Barrier Function and a "Leaky Gut"
  • Intestinal Barrier Dysfunction and Chronic Inflammation
  • CONCLUSION
  • REFERENCES
  • 22 - Translating Microbiome Science to Society-What's Next?
  • INTRODUCTION
  • WHAT SHOULD CHANGE-OBSTACLES TO LINKING SCIENCE AND SOCIETY
  • FLAWED CONCEPTS AND BAD LANGUAGE
  • UNREALISTIC EXPECTATIONS AND EXTRAPOLATIONS FROM EXPERIMENTAL ANIMALS
  • CHALLENGES AND OPPORTUNITIES
  • CONCLUSION-BOLD PREDICTIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z
  • Back Cover

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