Neuronal Codes of the Cerebellum

Neuronal Codes of the Cerebellum
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 7. Oktober 2015
  • |
  • 280 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-801675-6 (ISBN)
 

The Neuronal Codes of the Cerebellum provides the most updated information on what is known on the topics of the cerebellum's anatomy and single cell physiology, two areas where there has been a gap in knowledge regarding the specific codes it uses to process information internally and convey commands to other brain regions. This has created difficulties for researchers and clinicians looking to develop an understanding of the mechanisms by which it contributes to behavior and how its dysfunction causes neurological symptoms.

Focused on findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes, this edited volume will aid scientists in overcoming that knowledge gap, also serving as the first resource to broadly address the different aspects of spike coding in the cerebellum that focuses on spike train analysis.


  • Compiles current knowledge about functioning of the cerebellum on a cellular basis and how information is encoded in the cerebellum
  • Highlights findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes
  • Contents include an introduction to the cerebellum and experimental/theoretical techniques, as well as the function of cerebral coding during disorder, learning, behavior generation, motor behavior, and more
  • Bridges the gap for cerebellar researchers between single cell biophysics/anatomic studies and behavioral studies
  • Incorporates various in vivo approaches with different behavioral paradigms in primates and rodents, modeling studies of coding, and in vitro approaches
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 4,70 MB
978-0-12-801675-6 (9780128016756)
0128016752 (0128016752)
weitere Ausgaben werden ermittelt
  • Front Cover
  • THE NEURONAL CODES OF THE CEREBELLUM
  • Copyright
  • Contents
  • Contributors
  • Foreword
  • Preface
  • 1 - Signaling of Predictive and Feedback Information in Purkinje Cell Simple Spike Activity
  • INTRODUCTION
  • PURKINJE CELL DISCHARGE SIGNALS MANY FEATURES OF MOVEMENTS
  • PURKINJE CELL DISCHARGE AND MOTOR ERRORS
  • COMPUTATIONAL FRAMEWORK FOR CEREBELLAR INFORMATION PROCESSING
  • PREDICTIVE AND FEEDBACK SIGNALING IN PURKINJE CELL SIMPLE SPIKE FIRING
  • INTEGRATION OF SIMPLE SPIKE KINEMATIC AND ERROR SIGNALS
  • CONCLUSIONS
  • References
  • 2 - Deep Cerebellar Nuclei Rebound Firing In Vivo: Much Ado About Almost Nothing?
  • INTRODUCTION
  • THE COMPUTATIONAL PRINCIPLES OF THE CEREBELLUM
  • THE DEEP CEREBELLAR NUCLEI: THE CEREBELLUM'S GATEWAY TO THE BRAIN
  • REBOUND DEPOLARIZATION: A POTENTIAL FEATURE OF SPONTANEOUSLY ACTIVE NEURONS
  • LOW-THRESHOLD T-TYPE CALCIUM CHANNELS AND REBOUND FIRING
  • REBOUND FIRING: AN INTRIGUING AND EFFECTIVE CODING MECHANISM THAT CONVERTS INHIBITORY INPUTS TO EXCITATORY ONES
  • REBOUND FIRING IN THE DEEP CEREBELLAR NUCLEI NEURONS: A PROMINENT BIOPHYSICAL FEATURE
  • DEEP CEREBELLAR NUCLEI REBOUND FIRING: THE DEVIL IS IN THE DETAILS
  • How Effective are Purkinje Cell Inputs in Hyperpolarizing Deep Cerebellar Nuclei Neurons?
  • Rebound Firing Following Electrical or Optogenetic Stimulation In Vivo
  • What Constitutes Meaningful Rebound Firing?
  • PHYSIOLOGICAL REBOUND FIRING IN VIVO
  • CONCLUSIONS
  • References
  • 3 - Classical Conditioning of Timed Motor Responses: Neural Coding in Cerebellar Cortex and Cerebellar Nuclei
  • BEHAVIORAL ASPECTS OF EYEBLINK CONDITIONING
  • Conditional Stimulus-Unconditional Stimulus Interval
  • Conditioned Response Amplitude
  • Latency to Conditioned Response Peak
  • Latency to the Conditioned Response Onset
  • Varying Conditional Stimulus Duration after Acquisition
  • NEURAL CIRCUITS ENGAGED DURING EYEBLINK CONDITIONING
  • Lesions of the Cerebellar Nuclei
  • Lesions of the Cerebellar Cortex
  • Unconditional Stimulus and Unconditioned Response Pathway
  • Conditional Stimulus Pathway
  • Conditioned Response Pathway
  • Contribution of Extracerebellar Structures
  • NEURAL PLASTICITY IN THE CEREBELLAR CORTEX AND CEREBELLAR NUCLEI
  • Learning versus Performance
  • Cerebellar Cortex versus Cerebellar Nuclei
  • Learning in the Cerebellar Cortex
  • Plasticity Mechanisms in the Cerebellar Cortex
  • Plasticity in Cerebellar Nuclei
  • Plasticity Mechanisms in the Cerebellar Nuclei
  • CONCLUSIONS
  • CONFLICT OF INTEREST
  • References
  • 4 - How the Vestibulocerebellum Builds an Internal Model of Self-motion
  • INTRODUCTION
  • BASIC ORGANIZATION OF THE PERIPHERAL VESTIBULAR SYSTEM
  • FRAMEWORK OF THE INTERNAL MODEL
  • TILT- AND TRANSLATION-SELECTIVE NEURONS IN THE CEREBELLUM
  • SPATIOTEMPORAL TUNING
  • REVEALING THE INTERNAL MODEL COMPUTATIONS
  • DISCUSSION
  • LIST OF ABBREVIATIONS
  • MATHEMATICAL VARIABLES
  • References
  • 5 - Modeling the Generation of Cerebellar Nuclear Spike Output
  • INTRODUCTION
  • CEREBELLAR NUCLEUS NEURONS AS SIMPLE INVERTERS
  • MODELING REBOUND RESPONSES
  • TIME-LOCKING, SYNCHRONY CODING, AND THE EFFECT OF IRREGULARITY
  • CONCLUSIONS
  • References
  • 6 - Cerebrocerebellar Loops in the Rodent Brain
  • INTRODUCTION
  • THE CORTICOCEREBELLAR PATHWAY
  • MOSSY FIBERS
  • CLIMBING FIBERS
  • PARALLEL FIBERS
  • CEREBELLOCEREBRAL CONNECTIONS
  • FUNCTIONAL MAPPING OF THE CEREBELLOCEREBRAL CONNECTIONS
  • CONCLUSION
  • References
  • 7 - Cerebellar Neuronal Codes-Perspectives from Intracellular Analysis In Vivo
  • INTRODUCTION
  • THE CONFIGURATION OF THE CEREBELLAR CORTICAL NETWORK
  • Anatomical Structure of the Cerebellar Neuronal Network
  • Synaptic Plasticity
  • Physiological Gating Effects
  • THE FLOW OF INFORMATION THROUGH THE CEREBELLAR NEURONAL NETWORK
  • The Mossy Fiber-to-Granule Cell Synapse
  • The Golgi Cell-to-Granule Cell Synapse
  • The Interneuron-to-Purkinje Cell Synapse
  • The Granule Cell-to-Purkinje Cell Synapse
  • The Synaptic Inputs to Golgi Cells
  • The Excitatory and Inhibitory Synapses on Molecular Layer Interneurons
  • Summary of the Consequences of the Low-Weight Synaptic Organization
  • SPIKE ENCODING IN THE CEREBELLAR NEURONS
  • DISTRIBUTED NEURONAL REPRESENTATIONS
  • CONCLUSIONS
  • References
  • 8 - The Role of the Cerebellum in Optimizing Saccades
  • THE OCULOMOTOR VERMIS: THE MAJOR CEREBELLAR SITE OF SACCADES AND SACCADIC ADAPTATION
  • THE CAUDAL FASTIGIAL NUCLEUS: A GATEWAY FOR SACCADE-RELATED SIGNALS ORIGINATING FROM THE OCULOMOTOR VERMIS
  • SUMMARY
  • References
  • 9 - Coordination of Reaching Movements: Cerebellar Interactions with Motor Cortex
  • ANATOMICAL CONNECTIVITY SUGGESTS DISTINCT ROLES FOR THE DENTATE AND INTERPOSITUS NUCLEI IN THE MOTOR SYSTEM HIERARCHY
  • DEEP CEREBELLAR NUCLEI NEURONS HAVE HIGH SPONTANEOUS FIRING RATES ABOUT WHICH MOVEMENT-RELATED MODULATION OCCURS
  • RELATIVE TIMING OF DENTATE AND INTERPOSITUS ACTIVITY WITH RESPECT TO MOVEMENT ONSET
  • TEMPORAL CORRELATION WITH SENSORY CUES OR MOTOR RESPONSES
  • DEEP CEREBELLAR NUCLEI NEURONS TEND TO SHOW INCREASED ACTIVITY DURING MOVEMENT
  • THE CODING OF MOVEMENT-RELATED PARAMETERS IN THE DEEP CEREBELLAR NUCLEI
  • DOES SPECIFIC INFORMATION ABOUT MOVEMENT PARAMETERS GET SENT TO MOTOR CORTEX FROM THE DEEP CEREBELLAR NUCLEI?
  • FUTURE DIRECTIONS AND CONCLUDING THOUGHTS
  • References
  • 10 - A Spatiotemporal Hypothesis on the Role of 4- to 25-Hz Field Potential Oscillations in Cerebellar Cortex
  • INTRODUCTION
  • SYNCHRONIZATION AND OSCILLATIONS IN CEREBELLAR CIRCUITS
  • CEREBELLAR CORTEX 4- TO 25-HZ OSCILLATIONS
  • SPATIOTEMPORAL ASPECTS OF GRANULE CELL LAYER SYNCHRONIZATION
  • CIRCUIT INTERACTIONS-A POTENTIAL EFFERENCE COPY ROLE?
  • CONDITIONS SUPPORTING A PREDICTIVE SENSORIMOTOR DIALOG
  • GRANULE CELL LAYER OSCILLATIONS AND INTERNAL MODELS
  • CONCLUSION-AND BACK TO THE HOCKEY .
  • References
  • 11 - Single-Neuron and Network Computation in Realistic Models of the Cerebellar Cortex
  • INTRODUCTION
  • BIOPHYSICALLY DETAILED MODELS OF THE CEREBELLAR NEURONS AND MICROCIRCUITS
  • Modeling One of the Simplest Neurons: The Granule Cell
  • Modeling Special Properties in Granular Layer Interneurons: The Golgi Cell and Unipolar Brush Cell
  • The First Detailed Network Model of Cerebellar Microcircuits: The Granular Layer
  • Modeling One of the Most Complex Neurons: The Purkinje Cell
  • Models of the Deep Cerebellar Nuclei and Inferior Olivary Cells
  • LARGE-SCALE SPIKING MODELS OF THE OLIVOCEREBELLAR NETWORK
  • REAL-TIME MODELS FOR CLOSED-LOOP ROBOTIC SIMULATIONS OF CEREBELLAR LEARNING AND CONTROL
  • Traditional Robotic Models
  • Liquid-State Machine Models
  • Closed-Loop Real-Time Robotic Simulations Using Spiking Cerebellar Networks
  • CONCLUSIONS
  • LIST OF ABBREVIATIONS
  • References
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • L
  • M
  • O
  • P
  • R
  • S
  • T
  • U
  • V
  • Z
  • Back Cover

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