Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Volume 10
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 14. Juni 2016
  • |
  • 370 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-809428-0 (ISBN)
 

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 10 offer a valuable guide to both cellular processes, while encouraging researchers to explore their potentially important connections. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis.

This is the tenth volume of the multivolume series that discusses, in detail, almost all aspects of the autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. Volume 10 of the Autophagy series discusses the role of a novel binuclear palladacycle complex that inhibits melanoma growth through apoptosis and autophagy.


  • Presents the most advanced information regarding the role of the autophagic system in life and death
  • Contains a direct focus on the role of a novel binuclear palladacycle complex that inhibits melanoma growth
  • Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
  • States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities
  • Edited work with chapters authored by leaders in the field from around the globe-the broadest, most expert coverage available
  • Englisch
  • Saint Louis
  • |
  • USA
Elsevier Science
  • 8,59 MB
978-0-12-809428-0 (9780128094280)
0128094281 (0128094281)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Autophagy
  • Copyright Page
  • Dedication
  • 10 Lines of Autophagy for Volume 10
  • Mitophagy and Biogenesis
  • Autophagy and Cancer
  • Some Thoughts on Autophagy and Immunity
  • Autophagy: Friend or Foe?
  • Autophagy: If and When
  • What Happened When Autophagy Didn't
  • Sugar Isn't Always Sweet
  • Mitochondrial Mysteries
  • A Photo Is Static, An Instant in Time
  • Autophagy Subversion
  • Contents
  • Foreword by Roberta A. Gottlieb
  • Foreword by Eeva-Liisa Eskelinen
  • Preface
  • Contributors
  • Autophagy: Volume 1-Contributions
  • Autophagy: Volume 2-Contributions
  • Autophagy: Volume 3-Contributions
  • Autophagy: Volume 4-Contributions
  • Autophagy: Volume 5-Contributions
  • Autophagy: Volume 6-Contributions
  • Autophagy: Volume 7-Contributions
  • Autophagy: Volume 8-Contributions
  • Autophagy: Volume 9-Contributions
  • I. Molecular Mechanisms
  • 1 Overview of Autophagy
  • Specific Functions of Autophagy (A Summary)
  • Autophagy in Normal Mammalian Cells
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress
  • Major Types of Autophagies
  • Macroautophagy (Autophagy)
  • Microautophagy
  • Chaperone-Mediated Autophagy
  • Autophagosome Formation
  • Autophagic Flux
  • Autophagic Lysosome Reformation
  • Autophagy as a Double-Edged Sword
  • Protein Synthesis
  • Methods
  • Abnormal Proteins
  • Molecular Chaperones
  • The Endoplasmic Reticulum
  • Endoplasmic Reticulum and Apoptosis
  • Autophagic Proteins
  • Protein Degradation Systems
  • Beclin 1
  • Nonautophagic Functions of Autophagy-Related Proteins
  • Microtubule-Associated Protein LC3
  • Aggrephagy
  • Aggresome, Ubiquitin Proteasome, and Autophagic Systems
  • Monitoring Autophagy
  • Reactive Oxygen Species (ROS)
  • Mammalian Target of Rapamycin (mTOR)
  • Role of Autophagy in Tumorigenesis and Cancer
  • Role of Autophagy in Immunity
  • Autophagy and Senescence
  • Role of Autophagy and Cellular Senescence in Aging
  • Role of mTOR
  • Response by mTOR and Autophagy to Dietary Restriction
  • Role of Sirtuins
  • Role of Stem Cells
  • Role of Cellular Senescence
  • Effect of Aging on Skeletal Muscle
  • Role of Autophagy in Heart Disease
  • Role of Autophagy in HD
  • Role of Autophagy in AD
  • Role of Autophagy in Macular Degeneration
  • Role of Autophagy in Viral Defense and Replication
  • Role of Autophagy in Intracellular Bacterial Infection
  • Role of Autophagy in Heart Disease
  • Role of Autophagy in Neurodegenerative Diseases
  • Cross-Talk Between Autophagy and Apoptosis
  • Autophagy and Ubiquitination
  • Autophagy and Necroptosis
  • Mitochondrial Fusion and Fission
  • Selective Autophagy
  • Allophagy
  • Axonophagy (Neuronal Autophagy)
  • Chromatophagy
  • Ciliophagy
  • Crinophagy
  • Exophagy
  • Glycophagy
  • Lipophagy
  • Lysophagy
  • Mitophagy
  • Nucleophagy
  • Pexophagy
  • Role of Pexophagy in Yeast
  • Reticulophagy
  • Ribophagy
  • Xenophagy
  • Zymophagy
  • References
  • 2 Molecular Mechanisms Underlying the Degradation of Peroxisomes
  • Introduction
  • Molecular Mechanisms of Selective Autophagy
  • The PAS Assembly
  • Cargo Receptors: The Key Factors in Selective Autophagy
  • Pexophagy in Yeast
  • Cargo Recognition
  • Pexophagy-Specific PAS
  • Upstream Signaling
  • Pexophagy in Mammals
  • Cargo Recognition
  • Upstream Signaling
  • Discussion
  • Acknowledgments
  • References
  • 3 Role of Poly(ADP-Ribose) in Catalyzing Starvation-Induced Autophagy
  • PARPs: Concept and Family
  • PARP-1: Structure and Biochemistry of PARylation
  • Cellular Effects of PARPs Activation
  • PAR-Mediated Cell Death
  • Types of Cell Death: General Concepts
  • PARP and PARylation in Cell Death
  • PARthanatos
  • Necroptosis (PARP-1 and Regulated Necrosis)
  • Autophagy: Concept, Functions, and Types
  • Autophagosomes and Autolysosomes: Formation, Fusion, and Degradation
  • Autophagy Signaling Through PAR and PARP-1
  • Concluding Remarks
  • Acknowledgments
  • References
  • 4 Cross-Talk Between Autophagy and Death Receptor Signaling Pathways
  • Apoptosis
  • Extrinsic Apoptosis Induced by the Fas and Trail Receptors
  • Signal Transduction Through TNF-R1
  • Autophagy
  • Autophagy and Programmed Cell Death
  • Cross-Regulatory MechanismS within Autophagy and Programmed Cell Death
  • Autophagy and the Trail and Fas Receptors Signaling Pathways
  • Autophagy and the TNFR Signaling Pathway
  • Conclusion
  • Acknowledgments
  • References
  • 5 Role of Autophagy in Mammalian Embryogenesis: Response to Developmental Programs
  • Introduction
  • Autophagy in the Early Embryogenesis in Mammals
  • Autophagy in Somatic Cell Reprogramming
  • Autophagy in Gastrulation
  • Autophagy in Nerve Tissue Development
  • Endocytosis and Autophagy in the Developmental Context
  • References
  • 6 Autophagy in Adipose Tissue
  • Adipose Tissue and Adipokines
  • Obesity
  • Caloric Restriction
  • Autophagy Flux
  • Autophagy in Adipocytes and Adipose Tissue
  • Autophagy in Obese Adipose Tissue
  • Autophagy, Aging, and CR
  • Possible Role of Autophagy in Adipose Tissue
  • References
  • 7 Prevention of Adverse Metabolic Consequences of Adipocyte Dysfunction Using MR Antagonists
  • Introduction
  • MR in Adipose Tissue Physiology and Pathophysiology
  • Autophagy in Adipose Tissue Development
  • Autophagy in Dysfunctional Adipose Tissue
  • MR and Regulation of Autophagy
  • Discussion
  • Acknowledgments
  • References
  • 8 A Rapid Method for Detecting Autophagy Activity in Live Cells Using Cellometer Image Cytometry
  • Introduction
  • Cellometer Image Cytometer and Disposable Counting Chamber
  • Flow Cytometry Analysis
  • Cyto-ID Green Autophagy Dye for Live Cell Autophagosome Staining
  • Validation of Cyto-ID Green Autophagy Dye via Fluorescent Microscopy
  • Validation of Autophagy Detection Using Image Cytometry
  • Starvation and Recovery Assay
  • Autophagic Flux Assay
  • Time-Course Detection of Rapamycin-Induced Autophagy
  • Autophagic Dose-Response Comparison of Rapamycin and Tamoxifen
  • Discussion
  • References
  • II. Role in Disease
  • 9 Cdc37: Implications in Regulation of Kinases and Proteins Linked to Neurodegenerative and Other Diseases
  • Introduction
  • Cdc37 as an Hsp90 Co-chaperone
  • Cdc37 and Kinases
  • Role in Neurodegenerative Diseases: Cdc37 and TDP-43
  • Role in Neurodegenerative Diseases: Cdc37 and Tau
  • Cdc37 and Autophagy
  • Therapeutic Potential of Cdc37
  • Conclusions
  • References
  • 10 Autophagy in the Degeneration of Optic Nerve and Spinal Cord Axons
  • Introduction
  • Axonal Degeneration
  • Autophagy
  • Autophagy in the Optic Nerve
  • Axonal Degeneration after Traumatic Lesion of the Optic Nerve
  • Optic Nerve Degeneration in Glaucoma Models
  • Autophagy and Axonal Degeneration after Traumatic SCI
  • Conclusion
  • References
  • 11 Membrane Type-1 Matrix Metalloproteinase-Regulated Autophagy: A Role in Brain Cancer Chemoresistance
  • Abbreviations
  • Introduction
  • Barriers to Brain Cancer Growth
  • Resistance to Current Treatments for Brain Cancer
  • ECM Degradation and Matrix Metalloproteinases: A Link to the Chemoresistance Phenotype
  • Matrix Metalloproteinases
  • Membrane Type-1 Matrix Metalloproteinase
  • Discussion
  • Targeting Autophagy to Fight Cancer
  • MTCBP-1
  • References
  • 12 Induction of Autophagy and Apoptosis in Melanoma Treated With Palladacycle Complexes
  • Introduction
  • Apoptosis
  • Intrinsic Apoptosis
  • Extrinsic Apoptosis
  • Autophagy in Melanoma
  • Autophagy as a Tumor Suppressor Mechanism
  • Autophagy Supports Tumor Progression and Metastasis
  • The Expression of Atg Proteins in Melanoma Specimens
  • The Dual Role of Autophagy in Melanoma Treatments
  • Cross-Talk Between Apoptosis and Autophagy
  • Pd-Based Compounds
  • Bidentate Nitrogen Ligands
  • Phosphine Ligands
  • Antitumor Activity of Pd-Based Compounds in Melanoma
  • Induction of Apoptosis and Autophagy
  • Mechanisms of Antitumor Activity of Pd-Based Compounds
  • Induction of DNA Damage
  • Targeting Organelles
  • Signaling Pathways Affected by Pd-Based Compounds
  • Inhibition of the mTOR Pathway
  • Activation of MAPKs
  • References
  • 13 Autophagy in Atherosclerosis
  • Atherosclerosis
  • Detection of Autophagy in Atherosclerosis
  • Autophagy Detection via Transmission Electron Microscopy
  • Autophagy Detection via Immunohistochemistry or Fluorescence Microscopy
  • Autophagy Detection via Molecular Techniques
  • The Role of Autophagy in Atherosclerosis
  • Autophagy in VSMCs
  • Autophagy in Macrophages
  • Autophagy in Atherosclerosis
  • Pharmacological Modulation of Autophagy
  • mTOR Inhibition
  • AMPK and SIRT1 Activation
  • Calcium Regulation
  • Inhibition of Histone Acetylation
  • Other Mechanisms
  • Acknowledgments
  • References
  • Abbreviations and Glossary
  • Note
  • Index
  • Back Cover

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