Negative Affective States and Cognitive Impairments in Nicotine Dependence

 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 17. August 2016
  • |
  • 362 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-802669-4 (ISBN)
 

Negative Affective States and Cognitive Impairments in Nicotine Dependence is the only book of its kind that addresses nicotine use and abuse in the context of negative reinforcement mechanisms. Written and edited by leading investigators in addiction, affective, genetic, and cognitive research, it provides researchers and advanced students with an overview of the clinical bases of these effects, allowing them to fully understand the various underlying dysfunctions that drive nicotine use in different individuals. In addition, this book examines animal models that researchers have utilized to investigate the biological bases of these dysfunctions.

The combination of clinical and preclinical approaches to understanding nicotine dependence makes this book an invaluable resource for researchers and practitioners seeking to develop targeted treatments aimed at ameliorating symptoms of nicotine dependence, as well as identifying premorbid differences in affective or cognitive function.


  • Provides a unique perspective on nicotine dependence that emphasizes negative reinforcement rather than positive reinforcement
  • Examines psychiatric comorbidities and alleviation of withdrawal states as motivation for continued tobacco use
  • Includes both clinical and preclinical perspectives
  • Includes genetic and multi-neurotransmitter perspectives on nicotine use and withdrawal
  • Emphasizes heterogeneity of underlying reasons for smoking, the need for multiple animal models to understand this heterogeneity, and the expectation of heterogeneous responses to potential treatments, underscoring the need for personalized therapeutics
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 4,57 MB
978-0-12-802669-4 (9780128026694)
0128026693 (0128026693)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Negative Affective States and Cognitive Impairments in Nicotine Dependence
  • Negative Affective States and Cognitive Impairments in Nicotine Dependence
  • Copyright
  • Dedication
  • Contents
  • List of Contributors
  • Preface
  • References
  • Acknowledgments
  • 1 - Overview of Nicotine Withdrawal and Negative Reinforcement (Preclinical)
  • INTRODUCTION
  • TOBACCO DEPENDENCE AND NICOTINE
  • THEORETICAL FRAMEWORK
  • POSITIVE REINFORCEMENT ASSOCIATED WITH NICOTINE USE
  • NEGATIVE REINFORCEMENT ASSOCIATED WITH NICOTINE USE
  • NEUROBIOLOGICAL MECHANISMS OF POSITIVE REINFORCEMENT
  • NEUROBIOLOGICAL MECHANISMS OF NEGATIVE REINFORCEMENT
  • TRANSLATIONAL ASPECTS OF THE NEUROBIOLOGY OF NEGATIVE REINFORCEMENT
  • References
  • 2 - Nicotine Withdrawal and Attentional Deficit Studies Across Species: Conflation With Attentional Dysfunction in Psychiatric Patients
  • NICOTINE USE, WITHDRAWAL, AND COGNITION
  • ATTENTIONAL DEFICITS RESULTING FROM NICOTINE WITHDRAWAL IN HUMANS
  • ATTENTIONAL DYSFUNCTION IN PSYCHIATRIC PATIENTS: OVERLAP WITH NICOTINIC RESEARCH
  • MECHANISMS UNDERLYING NICOTINIC EFFECTS ON ATTENTION
  • ATTENTIONAL DEFICITS FROM NICOTINE WITHDRAWAL IN ANIMALS
  • IMPLICATIONS AND FUTURE STUDIES
  • CONCLUSIONS
  • References
  • 3 - Preclinical Models of Nicotine Withdrawal: Targeting Impaired Cognition
  • INTRODUCTION
  • NICOTINE WITHDRAWAL IN LABORATORY RODENTS
  • NICOTINE EXPOSURE TO INDUCE PHYSICAL DEPENDENCE IN RODENTS
  • PHARMACOLOGICAL SCREENING
  • MEASURES OF COGNITION IN RODENT MODELS OF NICOTINE WITHDRAWAL
  • ANIMAL MODELS OF NICOTINE DEPENDENCE: WITHDRAWAL EFFECTS ON ATTENTION
  • PHARMACOLOGICAL TREATMENT OF NICOTINE DEPENDENCE
  • SUMMARY
  • References
  • 4 - Genetic, Developmental, and Receptor-Level Influences on Nicotine Withdrawal-Associated Deficits in Learning
  • INTRODUCTION
  • HIPPOCAMPUS-DEPENDENT LEARNING IS MORE SENSITIVE TO THE EFFECTS OF NICOTINE WITHDRAWAL THAN HIPPOCAMPUS-INDEPENDENT LEARNING
  • CHRONIC NICOTINE ACTS DIRECTLY IN THE HIPPOCAMPUS TO CHANGE NACHR FUNCTION AND DISRUPT LEARNING DURING WITHDRAWAL
  • GENETIC BACKGROUND MODULATES NICOTINE WITHDRAWAL EFFECTS ON LEARNING
  • EFFECTS OF NICOTINE WITHDRAWAL ON LEARNING VARY WITH AGE
  • CONCLUSION
  • References
  • 5 - Enhanced Tobacco Use Vulnerability in Adolescents, Females, and Persons With Diabetes
  • INTRODUCTION
  • NICOTINE REWARD AND WITHDRAWAL
  • ADOLESCENTS
  • FEMALES
  • PERSONS WITH DIABETES
  • OTHER POPULATIONS TO CONSIDER
  • CONCLUSION AND CLINICAL IMPLICATIONS
  • References
  • 6 - Detrimental Effects of Prenatal Exposure to Tobacco Smoke and Nicotine
  • INTRODUCTION
  • FUNCTIONAL ROLE OF NICOTINIC ACETYLCHOLINE RECEPTORS IN THE DEVELOPING NERVOUS SYSTEM
  • SOMATIC EFFECTS OF PRENATAL EXPOSURE TO TOBACCO SMOKE AND NICOTINE
  • Cardiovascular Outcomes
  • Metabolic Outcomes
  • Respiratory Outcomes
  • Fertility Outcomes
  • LONG-TERM NEUROBEHAVIORAL EFFECTS OF PRENATAL EXPOSURE TO TOBACCO SMOKE AND NICOTINE
  • Human Studies
  • Preclinical Studies
  • CONCLUSIONS
  • References
  • 7 - Contribution of Translational Genetic Research to Our Understanding of Nicotine Dependence
  • HUMAN GENETICS: WHAT SHOULD WE SEEK TO MODEL IN ANIMAL STUDIES?
  • GENETIC STUDIES OF POSITIVE REINFORCEMENT IN MICE
  • MOUSE MODELS OF NEGATIVE REINFORCEMENT
  • GENETIC PREDISPOSITION TO AFFECTIVE DEFICITS
  • GENETIC PREDISPOSITION TO COGNITIVE DEFICITS
  • WHERE DO WE GO NEXT?
  • References
  • 8 - Transmitters and Receptors in Nicotine Withdrawal Syndrome
  • INFLUENCE OF DIFFERING LABORATORY MODELS OF NICOTINE WITHDRAWAL
  • CHOLINERGIC MECHANISMS
  • DOPAMINE
  • SEROTONIN AND NOREPINEPHRINE
  • GLUTAMATE
  • GAMMA AMINOBUTYRIC ACID (GABA)
  • ENDOGENOUS OPIATE MECHANISMS
  • NONOPIOID PEPTIDES
  • SIGNAL TRANSDUCTION MECHANISMS
  • CONCLUDING THOUGHTS
  • References
  • 9 - The Cannabinoid System in Nicotine Dependence and Withdrawal
  • INTRODUCTION TO THE CANNABINOID SYSTEM
  • THE CANNABINOID SYSTEM AND THE REWARD PATHWAY
  • THE CANNABINOID SYSTEM AND NICOTINE DEPENDENCE
  • CB1 RECEPTORS
  • CB2 RECEPTORS
  • ENDOCANNABINOIDS AND NICOTINE DEPENDENCE
  • FAAH Inhibitors
  • Anandamide Uptake Inhibitors
  • PPARs
  • THE CANNABINOID SYSTEM AND NICOTINE WITHDRAWAL
  • CB1 RECEPTORS AND NICOTINE WITHDRAWAL
  • CB2 RECEPTORS AND NICOTINE WITHDRAWAL
  • ENDOCANNABINOIDS AND NICOTINE WITHDRAWAL
  • CONCLUSIONS
  • References
  • 10 - Critical Role for Brain Stress Systems in the Negative Affective State Associated With Nicotine Withdrawal
  • INTRODUCTION
  • DYSPHORIA AND NICOTINE WITHDRAWAL
  • CRF AND DYSPHORIA ASSOCIATED WITH NICOTINE WITHDRAWAL
  • NOREPINEPHRINE AND DYSPHORIA ASSOCIATED WITH NICOTINE WITHDRAWAL
  • References
  • 11 - The Habenulo-Interpeduncular Pathway and Nicotine Withdrawal
  • CHARACTERIZATION OF THE HABENULAR NUCLEI
  • Anatomical Structure and Discrete Expression Patterns
  • Efferent Projections of the Habenular Nuclei
  • THE HABENULO-INTERPEDUNCULAR PATHWAY AND NICOTINE
  • Nicotinic Signaling Mechanisms
  • Nicotine Withdrawal
  • Nicotine Reinforcement, Reward, and Aversion
  • CONCLUSIONS
  • References
  • 12 - A CLINICAL OVERVIEW OF NICOTINE DEPENDENCE AND WITHDRAWAL
  • A CLINICAL OVERVIEW OF NICOTINE DEPENDENCE AND WITHDRAWAL
  • Conceptualizing Nicotine Dependence
  • The Role of Nicotine
  • Development of Nicotine Dependence
  • Nicotine Withdrawal
  • Symptoms
  • Time Course and Severity of Nicotine Withdrawal
  • Craving
  • Negative Affect and Self-Control
  • SUMMARY
  • References
  • 13 - Epidemiologic Research on the Relationship of Nicotine Dependence to Psychiatric and Substance Use Disorders
  • INTRODUCTION
  • NICOTINE DEPENDENCE AND PSYCHIATRIC DISORDERS
  • Mood Disorders
  • Anxiety Disorders
  • Personality Disorders
  • Eating Disorders
  • NICOTINE DEPENDENCE AND SUBSTANCE USE DISORDERS
  • Alcohol Use Disorders
  • Substance Use Disorders
  • Gambling Disorder
  • SUMMARY AND CONCLUSIONS
  • References
  • 14 - Nicotine and Tobacco Smoking and Withdrawal in Schizophrenia
  • TOBACCO USE DISORDER IN SCHIZOPHRENIA
  • Vulnerability to Comorbidity
  • Alleviating Neuroleptic Side Effects and Negative Symptoms
  • SMOKING ABSTINENCE AND REINSTATEMENT
  • Nicotine Dependence
  • Nicotine Reinforcement
  • Nicotine Withdrawal and Craving
  • Cue-Related Craving
  • Non-Cue-Related Craving
  • Effects on Negative Affect
  • Effects on Negative and Depressive Symptoms
  • Effects of Nicotine Withdrawal on Cognitive Function
  • GREATER DIFFICULTY QUITTING
  • SUMMARY AND CONCLUSIONS
  • References
  • 15 - EMERGENT COGNITIVE IMPAIRMENT DURING EARLY NICOTINE WITHDRAWAL*
  • NEUROPHYSIOLOGICAL MECHANISMS OF COGNITIVE EFFECTS OF NICOTINE WITHDRAWAL
  • BENCH TO BEDSIDE MODELS OF COGNITION DURING NICOTINE WITHDRAWAL
  • Attention
  • Learning and Memory
  • Working Memory
  • Response Inhibition
  • SUMMARY AND CONCLUSIONS
  • References
  • 16 - Nicotine and Posttraumatic Stress Disorder
  • INTRODUCTION
  • TOBACCO USE AND PTSD
  • NICOTINE AND PTSD PHENOTYPES
  • Heightened Anxiety
  • Attention and Memory Deficits
  • Fear Conditioning and Extinction
  • SUMMARY
  • References
  • 17 - Nicotine Withdrawal and Depression: Clinical Studies-A Four-Factor Model for More Accurate Characterization
  • INTRODUCTION
  • FACTOR 1: DIFFERENTIAL RELAPSE AND DROPOUT
  • STUDIES EXPLICITLY DESIGNED TO CHARACTERIZE ABSTINENCE EFFECTS
  • FACTOR 2: DOWNWARD DRIFT IN SELF-REPORTED NEGATIVE AFFECT
  • FACTOR 3: QUIT-DATE PROXIMAL UPWARD BASELINE DRIFT
  • THE UPS AND DOWNS OF AFFECTIVE DRIFT AND WITHDRAWAL SCORES
  • FACTOR 4: LONG- AND SHORT-TERM CHRONODYNAMIC LIFE CHANGES AND EVENTS
  • OTHER VALUABLE DESIGNS
  • Abstinence and Anhedonia
  • Longitudinal Epidemiological Studies Using Complex Modeling and Controls
  • SUMMARY, CONCLUSIONS, AND NEW DIRECTIONS
  • References
  • 18 - Neuroimaging Insights Into the Multifaceted Nature of the Nicotine Withdrawal Syndrome
  • INTRODUCTION
  • AFFECTIVE DISTURBANCES
  • COGNITIVE IMPAIRMENTS
  • REWARD DYSREGULATION
  • SUMMARY AND FUTURE CONSIDERATIONS
  • References
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • Back Cover

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