New and Future Developments in Microbial Biotechnology and Bioengineering

Aspergillus System Properties and Applications
 
 
Elsevier (Verlag)
  • 1. Auflage
  • |
  • erschienen am 27. Oktober 2016
  • |
  • 314 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
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978-0-444-63513-6 (ISBN)
 

New and Future Developments in Microbial Biotechnology and Bioengineering: Aspergillus System Properties and Applications provides information on emerging issues related to recent advancements in aspergillus research and its applications in bioprocess technology, chemical engineering, genome biology, molecular taxonomy, secondary and metabolite production, industrial process and biofuels/bioenergy research, and alternative fuel development. The book covers the various novel enzymes secreted by these fungi and their specific use in the food, textile, pulp and paper, biocellulosic ethanol production, and other industries.

The book describes research and experimentation on aspergillus activity and directly connects them to their use in bioprocess technology, chemical engineering, bioremediation process, secondary metabolite production, pharmaceutical processes, protein production, industrial process, biofuels/bioenergy research, and alternative fuel development. Readers will find this book to be an indispensable resource for biotechnologists, biochemical engineers, biochemists, microbiologists, bioinformatics researchers, and other biologists who are interested in learning about the potential applications of these fungi.


  • Compiles available, up-to-date information on recent developments made in the study of aspergillus system properties
  • Contains global content from pioneering international authors
  • Presents current research efforts and links them to various applications, including uses in foods, textiles, pulp and paper, and in biocellulosic ethanol production
  • Provides an indispensable resource for biologists who are interested in learning about the potential applications of the fungi aspergillus
  • Englisch
  • Oxford
  • |
  • Niederlande
Elsevier Science
  • 9,11 MB
978-0-444-63513-6 (9780444635136)
0444635130 (0444635130)
weitere Ausgaben werden ermittelt
  • Front Cover
  • New and Future Developments in Microbial Biotechnology and Bioengineering
  • Copyright Page
  • Contents
  • List of Contributors
  • I. Biology and Biodiversity
  • 1 Biodiversity of the Genus Aspergillus in Different Habitats
  • Introduction
  • Methodology of Studying Aspergillus Biodiversity
  • Phenotypic Studies
  • Secondary Metabolite Profiling and Chemotaxonomy
  • Evolution of the Approach: Polyphasic Taxonomy of Aspergillus
  • Aspergillus Diversity in Different Habitats
  • Desert
  • Salterns
  • Aspergillus Xerophily in Different Habitats
  • Agricultural
  • Polar
  • Water-Related
  • Mangrove
  • Living Plants, Lichens, and Animals
  • Air and Settled Dust
  • Decaying Wood and Mummies
  • Stones
  • Human
  • Fossils
  • Conclusions
  • References
  • 2 Understanding the Diversity of Aspergillus by Next-Generation Sequencing
  • Introduction
  • Methods for the Diversity Assessments of Different Aspergillus Species
  • Morphological Characters
  • Molecular Methods for the Characterization of Aspergillus Species
  • Traditional Sequencing of Aspergillus Species
  • Gene Level
  • Whole-Genome Sequencing
  • Next-Generation Sequencing
  • Roche 454 FLX Pyrosequencer
  • Illumina Genome Analyzer
  • Applied Biosystem Sequencing by Oligonucleotide Ligation and Detection (SOLiD) Sequencer
  • Ion Personal Genome Machine (PGM)
  • Heliscope Single-Molecule Sequencer
  • RNA Seq (NGST)
  • Pacific Biosciences SMRT DNA Sequencer
  • Conclusion
  • References
  • 3 Molecular Evolution of Aspergillus
  • Aspergillus Generalities
  • Aspergillus Role in Nature
  • Aspergillus as Pathogen
  • Aspergillus Usefulness for Humankind
  • Enzyme and Metabolite Production
  • Aspergillus Diversity
  • Aspergillus niger
  • Chromosomal Rearrangements
  • Genome Sequencing of Aspergillus Species
  • Genetic Sequences for Phylogeny
  • Evolution of Secondary Metabolite Production Pathways
  • Horizontal Gene Transfer
  • Future Trends
  • References
  • II. Secretion and Protein Production
  • 4 Heterologous Expression of Proteins in Aspergillus
  • Historical Context
  • Biosafety
  • Fermentation Systems for Protein Production in Aspergillus: Scale-Up
  • Homologous Protein Production for Industrial Application
  • Enhancing Heterologous Protein Expression
  • Transformation Efficiency
  • Vector Design: Promoter, Selectable Markers, and Signal Peptide Optimization
  • Codon Optimization
  • 5´ UTR Sequences
  • Glycosylation
  • High Secretion Strategies
  • Looking for Protease-Deficient Strains
  • Human Proteins Expressed in Aspergillus
  • Synthetic Biology as an Innovative Approach for the Biosynthesis of Novel Compounds
  • Bioremediation
  • References
  • 5 Aspergillus Secretome: An Overview
  • Introduction
  • Secretome
  • Access to Secretome
  • Genomic Analysis
  • Proteomics Approach
  • Bioinformatics Approach
  • Genomic Analysis
  • Proteomics Approach
  • Bioinformatics Approach
  • Recent Breakthroughs
  • Genomics
  • Proteomics
  • Bioinformatics
  • Conclusion
  • References
  • III. Secondary Metabolism
  • 6 Secondary Metabolism and Antimicrobial Metabolites of Aspergillus
  • Introduction
  • Metabolites
  • Polyketides
  • Lovastatin
  • Aflatoxin B1
  • Ochratoxin
  • Enzymes
  • Lipases
  • Laccases
  • Tannases
  • Pectinases
  • Proteases
  • Lactases
  • Cellulases
  • Amylases
  • Organic Acids
  • Citric Acid
  • Itaconic Acid
  • Kojic Acid
  • Gluconic Acid
  • Final Remarks
  • Acknowledgments
  • References
  • 7 Fungal Volatile Organic Compounds (VOCs) and the Genus Aspergillus
  • Introduction to Volatile Organic Compounds
  • Overview of Fungal Volatiles and Their Effects
  • Isolation and Identification of Volatiles
  • VOCs as Taxonomic Characters and as Indicators of Fungal Growth
  • Taxonomic Identification
  • Detection of Mold Growth in Indoor Environments
  • Detection of Spoilage and Mycotoxin Contamination in Foods and Feeds
  • Medical Diagnosis of Aspergillosis
  • VOCs as Aroma Compounds
  • Food Aroma and Flavor
  • Improvement of Tobacco Aroma
  • Spoilage
  • Physiological Effect of Aspergillus VOCs
  • Semiochemicals for Arthropods and Other Interspecific Effects
  • Developmental Signals in Fungi
  • VOCs as Products of Aspergillus Enzymatic Biotransformations
  • Volatiles and Biodegradation
  • Gosio Gas
  • Commercial and Other Biotransformations
  • Summary and Prospects for Future Research
  • References
  • IV. Tools
  • 8 Molecular Tools for Strain Improvement in Aspergillus
  • Introduction
  • Aspergillus Strain Improvement
  • Conventional Genetic Approach
  • Strain Mating Approach
  • Direct Selection Approach
  • Gene Targeting Approach: Functional Loss of Target Gene Conferring Toxicity
  • Functional Gene Analysis
  • Homologous Versus Nonhomologous Recombination
  • Promoter Analysis
  • Application of RNA Interference
  • Desired Gene Fusion with a Strongly Expressed Genes
  • Site-Directed Insertional Mutagenesis
  • Signaling Pathways
  • Inherent Function-Candidate Genes
  • Transposon-Mediated Insertional Mutagenesis
  • Conclusions
  • References
  • V. Applications
  • 9 Enzyme System from Aspergillus in Current Industrial Uses and Future Applications in the Production of Second-Generation ...
  • Introduction
  • Biodiversity and Bioprospecting
  • The Genus Aspergillus
  • Section Nigri
  • Enzyme System from Aspergillus Applied in Current Industrial Uses and Second-Generation Ethanol
  • Lignocellulosic Biomasses Depolymerization for Second-Generation Ethanol Production
  • Structure and Degradation of Cellulose
  • Structure and Degradation of Hemicellulose
  • Perspectives and Concluding Remarks
  • Acknowledgments
  • References
  • 10 Advances in Cultivation Strategies of Aspergillus for Production of Enzymes Involved in the Saccharification of Lignocel ...
  • Introduction
  • Enzymes Involved in the Saccharification of Lignocellulosic Feedstocks
  • Cultivation of Aspergillus Under SmF
  • Medium Selection
  • Temperature and pH
  • Mixing and Aeration
  • Type of SmF Bioreactor
  • Conventional Stirred Tank Versus Pneumatic Bioreactors
  • Cultivation of Aspergillus Under SSF
  • Temperature
  • Moisture Content
  • Aeration
  • Type of SSF Bioreactor
  • Novel Approaches for (Hemi)Cellulolytic Enzyme Production by Aspergillus
  • Concluding Remarks
  • References
  • 11 ß-Glucosidase From Aspergillus
  • Introduction
  • Aspergillus as Enzyme Producers
  • Production of ß-Glucosidase using Aspergillus Strains
  • Purification and Characterization of ß-Glucosidases
  • Engineering of Aspergillus Strains and ß-Glucosidase from Aspergillus
  • Applications of ß-Glucosidase from Aspergillus
  • Food Industry
  • Pharmaceutical Industry
  • Biofuels Industry
  • Chemical Industry
  • Immobilization of ß-Glucosidases from Aspergillus sp.
  • Physical Adsorption
  • Entrapment or Encapsulation
  • Covalent Binding
  • Conclusions
  • References
  • 12 Regulation and Heterologous Expression of Lignocellulosic Enzymes in Aspergillus
  • Introduction
  • Structure of Plant Cell Wall
  • The Lignocellulolytic System
  • Cellulases
  • Hemicellulases
  • Xylanases and Xylosidases
  • Arabinohydrolases
  • Xylan a-1,2-Glucuronidases
  • Esterases of Hemicellulose
  • Mannan-Degrading Enzymes
  • Regulation of Lignocellulolytic Enzymes in Aspergillus Species
  • Regulation of the Cellulolytic System
  • Regulation of the Hemicellulolytic System
  • Carbon Catabolite Repressor CreA
  • Heterologous Expression in Aspergillus
  • Aspergillus Strains Commonly Used as Heterologous Hosts
  • Genetic Manipulation and Improvement of Expression Strategies
  • Heterologous Expression of Lignocellulose-Degrading Enzymes in Aspergillus
  • Cellulases and Hemicellulases
  • Lignin-Modifying Enzymes
  • Conclusions
  • References
  • 13 Aspergillus Enzymes for Textile Industry
  • Textile Industry: A Major Industrial Sector Worldwide
  • Microbial Enzymes for the Textile Industry: Revolutionary Step in the Industrial World
  • Fungal Enzymes for Textile Industry
  • Aspergillus Species
  • Aspergillus sp. for Industrial Applications
  • Future Scope
  • References
  • 14 Biosynthesis of Nanoparticles by Aspergillus and Its Medical Applications
  • Introduction
  • Metal Nanoparticles
  • Methods Employed for NP Synthesis
  • Medical Use and Importance
  • Diagnostics
  • Antimicrobial Properties
  • Hyperthermia
  • Drug Delivery
  • Toxicity
  • Final Remarks and Perspectives
  • Acknowledgments
  • References
  • 15 Role of Aspergillus in Bioremediation Process
  • Introduction
  • A Brief Scenario of Soil and Water Pollution and the Adverse Effects
  • Bioremediation: Its Necessity
  • HM Bioremediation by Aspergillus
  • Mechanism of HM Tolerance by Aspergillus
  • Bioremediation of Hydrocarbons by Aspergillus
  • Role of Aspergillus sp. in Textile Wastewater Cleaning
  • Conclusion
  • References
  • 16 Aspergillus Enzymes for Food Industries
  • Introduction
  • Fungus of Industrial Interest
  • Aspergillus Enzymes for Industries
  • Pectinases
  • Amylases
  • Cellulases
  • ß-Glucanases
  • Proteases
  • Lipases
  • Perspectives for Microbial Production of Enzymes by Aspergillus
  • References
  • 17 Applications of Aspergillus in Plant Growth Promotion
  • Introduction
  • Phosphorous Solubilization/Mineralization
  • Secondary Metabolites
  • Phytohormone
  • Conclusion
  • References
  • 18 Aspergillus in Biomedical Research
  • Introduction
  • Aspergillus as a Source of Important Therapeutic Enzymes
  • Amylase
  • Lipases
  • Protease
  • Ribonucleases
  • Aspergillus as a Source of Therapeutic Compounds
  • Fumagillin
  • Statins
  • a-Glucosidase Inhibitor
  • Tau Aggregation Inhibitor
  • Antioxidants
  • CCK Receptor Antagonists
  • Immunosuppressants
  • Probiotics
  • Molluscicides
  • Future Prospects of Using Aspergillus in Biomedical Research
  • References
  • 19 Aspergillus Applications in Cancer Research
  • Introduction
  • Different Classes of Compounds with Anticancer Activities
  • Anticancer Compounds from Aspergillus fumigatus
  • Depodophyllotoxin from Aspergillus fumigatus
  • Aspergillus terreus as the Source
  • Aspergillus ochraceous, Aspergillus sydowii, Aspergillus ustus and Aspergillus japonicus as Sources of Anticancer Alkaloids
  • Aspergillus niger as the Source of Anticancer Compounds
  • Aspergillus tubingensis
  • Aspergillus versicolor
  • Aspergillus nidulans
  • Aspergillus clavatus and Aspergillus flavipes as Sources of Cytotoxic Cytochalasins
  • Aspergillus wentii
  • Aspergillus candidus as a Source
  • Aspergillus parasiticus
  • Aspergillus glaucus
  • Unidentified Strains of Aspergilli as Sources of Anticancer Compounds
  • Conclusions and Future Perspectives
  • References
  • 20 Protein Production: Quality Control and Secretion Stress Response
  • Introduction
  • Genetic Strategies
  • Gene Fusion Strategy
  • Introducing Multicopies of Protein Gene for Higher Yields
  • Using a Protease-Deficient Host Strain
  • Engineering of the Glycosylation Pathway
  • Induction of UPR
  • Using Strong Promoters and Efficient Secretion Signals
  • Introducing Multiple Copies of Protein-Binding Sequence (CCAAT) to the Promoter
  • Bioprocessing Strategies
  • Fungal Morphology
  • Fungal Mycelia Immobilization
  • Fermentation pH Effects
  • Cultivation Medium
  • Agitation Intensity and Dissolved Oxygen Tension
  • Conclusion
  • References
  • 21 Bioremediation of Arsenic Using an Aspergillus System
  • Arsenic Contamination: A Societal Issue
  • Environmental Contamination
  • Health Effects of Arsenic
  • Bioremediation: Potential Solution
  • Use of Filamentous Fungi as Bioremediation Agents
  • Use of Aspergillus as an Arsenic Biosensor
  • Conclusions
  • References
  • 22 Secondary Metabolite Diversity of the Genus Aspergillus: Recent Advances
  • Introduction
  • Secondary Metabolites of Fungi
  • Secondary Metabolites of Aspergillus Species
  • Polyketides
  • Nonribosomal Peptides
  • Ribosomally Synthetized and Posttranslationally Modified Peptides (RiPPs)
  • Terpenes
  • Alkaloids
  • Bioinformatic Tools for Genome Mining of Secondary Metabolites in Aspergillus
  • Proteomics Approaches to Secondary Metabolite Discovery
  • Fungal Gene Regulation and Methods for Activating the Silent SM Genes/Clusters
  • Acknowledgments
  • References
  • Index
  • Back Cover

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