This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.
The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Reihe
Auflage
Sprache
Verlagsort
Verlagsgruppe
Springer International Publishing
Illustrationen
39
18 s/w Abbildungen, 39 farbige Abbildungen
XI, 181 p. 57 illus., 39 illus. in color.
Dateigröße
Schlagworte
ISBN-13
978-3-319-46877-8 (9783319468778)
DOI
10.1007/978-3-319-46877-8
Schweitzer Klassifikation
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BIC 2 Klassifikation
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Warengruppensystematik 2.0