Network Neuroscience

 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 20. September 2016
  • |
  • 482 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-801586-5 (ISBN)
 

Studying brain networks has become a truly interdisciplinary endeavor, attracting students and seasoned researchers alike from a wide variety of academic backgrounds. What has been lacking is an introductory textbook that brings together the different fields and provides a gentle introduction to the major concepts and findings in the emerging field of network neuroscience. Network Neuroscience is a one-stop-shop that is of equal use to the neurobiologist, who is interested in understanding the quantitative methods employed in network neuroscience, and to the physicist or engineer, who is interested in neuroscience applications of mathematical and engineering tools. The book spans 27 chapters that cover everything from individual cells all the way to complex network disorders such as depression and autism spectrum disorders. An additional 12 toolboxes provide the necessary background for making network neuroscience accessible independent of the reader's background. Dr. Flavio Frohlich (www.networkneuroscientist.org) wrote this book based on his experience of mentoring dozens of trainees in the Frohlich Lab, from undergraduate students to senior researchers. The Frohlich lab (www.frohlichlab.org) pursues a unique and integrated vision that combines computer simulations, animal model studies, human studies, and clinical trials with the goal of developing novel brain stimulation treatments for psychiatric disorders. The book is based on a course he teaches at UNC that has attracted trainees from many different departments, including neuroscience, biomedical engineering, psychology, cell biology, physiology, neurology, and psychiatry. Dr. Frohlich has consistently received rave reviews for his teaching. With this book he hopes to make his integrated view of neuroscience available to trainees and researchers on a global scale. His goal is to make the book the training manual for the next generation of (network) neuroscientists, who will be fusing biology, engineering, and medicine to unravel the big questions about the brain and to revolutionize psychiatry and neurology.


  • Easy-to-read, comprehensive introduction to the emerging field of network neuroscience
  • Includes 27 chapters packed with information on topics from single neurons to complex network disorders such as depression and autism
  • Features 12 toolboxes serve as primers to provide essential background knowledge in the fields of biology, mathematics, engineering, and physics


Flavio Fröhlich, PhD is an Assistant Professor in Psychiatry, Cell Biology and Physiology, Biomedical Engineering, and Neurology at the University of North Carolina at Chapel Hill. Dr. Fröhlich is a leader in the emerging field of Network Neuroscience and has received interdisciplinary training (electrical engineering, computational neuroscience, neurophysiology) at world-leading institutions (ETH Zurich, Salk Institute, UCSD, Yale). His laboratory conducts basic and translational research in the field of network neuroscience. Dr. Fröhlich has received numerous awards, including the prestigious NIMH BRAINS award for studying cortical network dynamics. He teaches a highly successful course Network Neuroscience at UNC that is attended by undergraduate and graduate students, medical residents, postdoctoral researchers, and neuroscience faculty.
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 43,77 MB
978-0-12-801586-5 (9780128015865)
0128015861 (0128015861)
weitere Ausgaben werden ermittelt
  • Front Cover
  • NETWORK NEUROSCIENCE
  • NETWORK NEUROSCIENCE
  • Copyright
  • Dedication
  • Contents
  • Preface
  • Introduction
  • References
  • I - NEURONS, SYNAPSES, AND CIRCUITS
  • 1 - Membrane Voltage
  • MEMBRANE VOLTAGE AND IONIC CURRENTS
  • MEASURING THE MEMBRANE VOLTAGE: CURRENT CLAMP
  • MEASURING IONIC CURRENTS: VOLTAGE CLAMP
  • DYNAMIC CLAMP
  • INSTRUMENTATION
  • Sharp Micropipette Intracellular Recordings
  • Whole-Cell Patch-Clamp Recordings
  • SUMMARY AND OUTLOOK
  • References
  • 2 - Dynamics of the Action Potential
  • POTASSIUM CURRENT
  • SODIUM CURRENT
  • ACTION POTENTIALS
  • SUMMARY AND OUTLOOK
  • Reference
  • 3 - Synaptic Transmission
  • THE CHEMICAL SYNAPSE
  • Presynaptic Voltage-Gated Calcium Channels
  • Presynaptic Calcium Dynamics
  • Postsynaptic Glutamate Receptors
  • Modeling Excitatory Synaptic Transmission
  • Metabotropic Glutamate Receptors
  • INHIBITORY SYNAPTIC TRANSMISSION
  • ELECTRICAL SYNAPSES
  • SUMMARY AND OUTLOOK
  • References
  • 4 - Synaptic Plasticity
  • SHORT-TERM PLASTICITY
  • Short-Term Depression
  • Synaptic Facilitation
  • Modeling Short-Term Plasticity
  • LONG-TERM PLASTICITY
  • Mechanism of LTP and LTD
  • Spike-Timing-Dependent Plasticity
  • Modeling Long-Term Plasticity
  • SUMMARY AND OUTLOOK
  • References
  • 5 - Neuromodulators
  • CORTICAL STATE
  • BASIC PRINCIPLES
  • ACETYLCHOLINE
  • Mechanisms
  • Behavior
  • DOPAMINE
  • Mechanisms
  • Behavior
  • NOREPINEPHRINE
  • Mechanisms
  • Behavior
  • HISTAMINE
  • Mechanisms
  • Behavior
  • SEROTONIN
  • Mechanisms
  • Behavior
  • MONOAMINE TRANSPORTERS
  • SUMMARY AND OUTLOOK
  • References
  • 6 - Neuronal Communication Beyond Synapses
  • CHEMICAL SIGNALING BEYOND SYNAPSES
  • Neuropeptides
  • Nitric Oxide
  • EXTRACELLULAR ION CONCENTRATION DYNAMICS
  • ENDOGENOUS ELECTRIC FIELDS
  • SUMMARY AND OUTLOOK
  • References
  • 7 - Microcircuits of the Neocortex
  • GLUTAMATERGIC CELLS
  • Pyramidal Cells
  • Spiny Stellate Cells
  • INHIBITORY INTERNEURONS
  • Basket Cells
  • Other Types of Inhibitory Interneurons
  • THE CORTICAL MICROCIRCUIT
  • Layered Circuits of the Neocortex
  • Inhibitory Circuits
  • SUMMARY AND OUTLOOK
  • References
  • 8 - Microcircuits of the Hippocampus
  • CIRCUIT LAYOUT OF THE HIPPOCAMPUS
  • DENTATE GYRUS
  • HIPPOCAMPAL FIELDS: CA1, CA2, AND CA3
  • CA1 Pyramidal Cells
  • CA3 Pyramidal Cells
  • SUBICULUM
  • ENTORHINAL CORTEX
  • FUNDAMENTAL LOCAL CIRCUIT PRINCIPLES
  • Excitatory Circuit Motifs
  • Inhibitory Circuit Motifs
  • SUMMARY AND OUTLOOK
  • NOTES
  • References
  • II - MEASURING, PERTURBING, AND ANALYZING BRAIN NETWORKS
  • 9 - Unit Activity
  • TERMINOLOGY AND CONCEPTS
  • ORIGIN OF THE EAP SIGNAL*
  • RECORDING STRATEGIES
  • SPIKE SORTING
  • ANALYZING AND VISUALIZING UNIT ACTIVITY
  • SUMMARY AND OUTLOOK
  • References
  • 10 - LFP and EEG
  • ELECTRIC FIELDS CAUSED BY NETWORK ACTIVITY
  • ELECTROENCEPHALOGRAM
  • LOCAL FIELD POTENTIAL
  • DATA ANALYSIS
  • SOURCE LOCALIZATION
  • INVASIVE RECORDING IN HUMANS
  • MAGNETOENCEPHALOGRAPHY
  • SUMMARY AND OUTLOOK
  • References
  • 11 - Optical Measurements and Perturbations
  • CALCIUM IMAGING
  • Calcium Indicators
  • Calcium Imaging Setup
  • Applications
  • VOLTAGE-SENSITIVE DYE IMAGING
  • VSDI Setup
  • Applications
  • OPTOGENETICS
  • Optogenetic Probes
  • Targeting: Achieving Specificity
  • Applications
  • SUMMARY AND OUTLOOK
  • References
  • 12 - Imaging Structural Networks With MRI
  • PHYSICS OF MRI
  • Nuclear Magnetic Resonance
  • Localizing the MR Signal
  • ANALYSIS OF STRUCTURAL MR IMAGING DATA
  • Image Preprocessing
  • Quantification of Structural Features
  • Quantification of White Matter Tracts: Diffusion Tensor Imaging*
  • SUMMARY AND OUTLOOK
  • References
  • 13 - Imaging Functional Networks With MRI
  • IMAGING CORRELATES OF NEURONAL ACTIVITY
  • Vascular Coupling of Neuronal Tissue
  • BOLD Signal
  • Source of the BOLD Signal
  • Comparison of the BOLD Signal to Alternative Imaging Strategies
  • Challenges and Limitations of fMRI
  • RESTING STATE FMRI
  • Networks of the Resting State
  • Data Preprocessing
  • Region of Interest Analysis
  • Independent Component Analysis
  • SUMMARY AND OUTLOOK
  • References
  • 14 - Deep Brain Stimulation
  • DEEP BRAIN STIMULATION PROCEDURE
  • CLINICAL APPLICATIONS
  • Parkinson's Disease
  • Essential Tremor
  • Dystonia
  • Depression
  • MECHANISMS OF DEEP BRAIN STIMULATION
  • SUMMARY AND OUTLOOK
  • References
  • 15 - Noninvasive Brain Stimulation
  • TRANSCRANIAL MAGNETIC STIMULATION
  • TRANSCRANIAL ELECTRICAL STIMULATION
  • Transcranial Direct Current Stimulation
  • Transcranial Alternating Current Stimulation
  • Transcranial Random Noise Stimulation
  • "Brain Hacking"
  • SUMMARY AND OUTLOOK
  • References
  • 16 - Network Interactions
  • FUNCTIONAL CONNECTIVITY
  • Cross-Correlogram
  • Coherence, Phase-Locking Value, and Intertrial Phase Coherence*
  • EFFECTIVE CONNECTIVITY
  • Granger Causality
  • Dynamic Causal Modeling
  • Mutual Information and Transfer Entropy*
  • SUMMARY AND OUTLOOK
  • References
  • III - CORTICAL OSCILLATIONS
  • 17 - Low-Frequency Oscillations
  • ANESTHESIA
  • Slow Oscillation of Anesthesia
  • SLEEP
  • Sleep Stages
  • Oscillations During NREM Sleep
  • Mechanisms of the Slow Oscillation
  • Functional Role of Low-Frequency Oscillations During NREM Sleep
  • AWAKE STATE
  • DISEASE STATE
  • DEVELOPMENT
  • SUMMARY AND OUTLOOK
  • References
  • 18 - Theta Oscillations
  • THETA OSCILLATIONS IN RODENTS
  • Mechanisms of Theta Oscillations in the Hippocampus
  • Memory and Navigation
  • Cell Assemblies and Theta Oscillations
  • THETA OSCILLATIONS IN PRIMATES
  • Memory and Navigation
  • Cognitive Control
  • SUMMARY AND OUTLOOK
  • References
  • 19 - Alpha Oscillations
  • TERMINOLOGY
  • MECHANISMS OF ALPHA OSCILLATIONS
  • FUNCTIONAL ROLES OF ALPHA OSCILLATIONS
  • Sensory Input Gating
  • Working Memory, Attention, and Creativity
  • Emotions
  • PROBING ALPHA OSCILLATIONS WITH NONINVASIVE BRAIN STIMULATION
  • SUMMARY AND OUTLOOK
  • References
  • 20 - Beta Oscillations
  • TERMINOLOGY
  • MECHANISMS OF BETA OSCILLATIONS
  • FUNCTIONAL ROLES OF BETA OSCILLATIONS
  • Dynamic Modulation of Beta Oscillations
  • Motor System
  • Closing the Sensorimotor Loop
  • Beyond the Sensorimotor Cortex
  • PROBING BETA OSCILLATIONS WITH NONINVASIVE BRAIN STIMULATION
  • MU RHYTHM
  • BETA OSCILLATIONS IN BRAIN-COMPUTER INTERFACES
  • SUMMARY AND OUTLOOK
  • References
  • 21 - Gamma Oscillations
  • TERMINOLOGY
  • CELLULAR AND NETWORK MECHANISMS OF GAMMA OSCILLATIONS
  • FUNCTIONAL ROLES OF GAMMA OSCILLATIONS
  • Organizing Network Activity into Cell Assemblies
  • Sensory Perception
  • Attention and Working Memory
  • CROSS-FREQUENCY COUPLING AND GROUPING OF GAMMA OSCILLATIONS
  • FAST GAMMA OSCILLATIONS ("HIGH GAMMA")
  • DEVELOPMENT
  • SUMMARY AND OUTLOOK
  • References
  • 22 - High-Frequency Oscillations
  • TERMINOLOGY
  • HIGH-FREQUENCY OSCILLATIONS IN THE HIPPOCAMPUS
  • Mechanisms
  • Functions
  • EVOKED HIGH-FREQUENCY OSCILLATIONS
  • Human Neocortex
  • Animal Neocortex
  • PATHOLOGICAL HIGH-FREQUENCY OSCILLATIONS: FAST RIPPLES
  • High-Frequency Oscillations in Epilepsy
  • Mechanisms
  • SUMMARY AND OUTLOOK
  • References
  • References
  • IV - NETWORK DISORDERS
  • 23 - Parkinson's Disease
  • SYMPTOMS
  • PATHOLOGY AND MEDICATION TREATMENT
  • ANIMAL MODELS
  • NETWORK PATHOLOGIES
  • NETWORK OSCILLATIONS
  • DEEP BRAIN STIMULATION
  • SUMMARY AND OUTLOOK
  • References
  • 24 - Epilepsy
  • EPILEPTOLOGY
  • ANTIEPILEPTIC DRUGS
  • SURGICAL TREATMENT OF EPILEPSY
  • Localizing Seizures by Electrophysiology
  • Localizing Seizures by Imaging
  • Localizing Seizures by Invasive Electrophysiology
  • BRAIN STIMULATION TREATMENT
  • MECHANISMS OF EPILEPTIC SEIZURES
  • Epileptic Spikes
  • Spike Waves
  • SUMMARY AND OUTLOOK
  • References
  • 25 - Schizophrenia
  • SYMPTOMS OF SCHIZOPHRENIA
  • Positive and Negative Symptoms
  • Auditory Hallucinations
  • Cognitive Function in Schizophrenia
  • BRAIN NETWORKS IN SCHIZOPHRENIA
  • Sensory Gating: The P50 Response
  • Cognitive Processing: The P300 Response
  • Auditory Steady-State Response
  • Cortical Oscillations
  • Structural Connectivity
  • MECHANISMS AND CAUSES OF SCHIZOPHRENIA
  • Cellular and Synaptic Impairment
  • Neurodevelopmental Origin
  • SUMMARY AND OUTLOOK
  • References
  • 26 - Autism Spectrum Disorders
  • SYMPTOMS OF AUTISM SPECTRUM DISORDERS
  • DYNAMICS AND STRUCTURE IN BRAIN NETWORKS IN AUTISM SPECTRUM DISORDERS
  • Macroscopic Network Dynamics: Electroencephalogram
  • Histology
  • (Functional) Magnetic Resonance Imaging
  • Behavioral Analogies of Altered Network Connectivity
  • MECHANISMS AND ETIOLOGY OF AUTISM SPECTRUM DISORDERS
  • Genes, Environment, and Multisystem Pathologies
  • Developmental Origin of Connectivity Deficits
  • SUMMARY AND OUTLOOK
  • References
  • 27 - Major Depressive Disorder
  • SYMPTOMS OF DEPRESSION
  • BRAIN NETWORKS IN DEPRESSION
  • Alpha Oscillations
  • Theta Oscillations
  • Network Dynamics of Sleep
  • MECHANISMS AND CAUSES OF DEPRESSION
  • Pathologies of the Stress Axis
  • Animal Models and Tests of Mood Disorders
  • BRAIN STIMULATION TREATMENTS
  • SUMMARY AND OUTLOOK
  • References
  • V- TOOLBOXES
  • Toolbox Neurons
  • Toolbox Animal Models
  • References
  • Toolbox Neurology
  • References
  • Toolbox Psychiatry
  • References
  • Toolbox Matlab
  • References
  • Toolbox Electrical Circuits
  • Toolbox Differential Equations
  • Toolbox Dynamical Systems
  • References
  • Toolbox Graph Theory
  • References
  • Toolbox Modeling Neurons
  • References
  • Toolbox Physics of Electric Fields
  • Reference
  • Toolbox Time and Frequency
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • Y
  • Back Cover

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