The Kinesin Superfamily Handbook

Transporter, Creator, Destroyer
 
 
CRC Press
  • 1. Auflage
  • |
  • erschienen am 13. Mai 2020
  • |
  • 186 Seiten
 
E-Book | ePUB ohne DRM | Systemvoraussetzungen
978-0-429-95824-3 (ISBN)
 

This book brings together current information on the families that make up the kinesin superfamily of molecular motors in one comprehensive text; an ideal reference for researchers looking to make comparisons between different families, for specific information on an individual family, or simply for an overview of the kinesin superfamily.
Information is clearly structured and grouped according to individual families and organised in a standardised way, allowing the reader to easily search and retrieve information on this large superfamily of molecular motors and understand how its individual members carry out a diverse variety of cellular functions.

Features:

    • The first book dedicated to the entire kinesin superfamily

    • Enables a fuller understanding of this family of proteins, which is becoming an increasing focus of research due to its involvement in diseases such as cancer, neuropathies and ciliopathies

    • Written in a manner accessible to a range of researchers in the life and medical sciences, including biophysicists, biochemists and medical researchers.

    Chapter 4 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here.

    Chapter 11 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here.

    1. Auflage
    • Englisch
    • London
    • |
    • Großbritannien
    Taylor & Francis Ltd
    • Für höhere Schule und Studium
    25 schwarz-weiße und 10 farbige Abbildungen
    • 2,82 MB
    978-0-429-95824-3 (9780429958243)
    weitere Ausgaben werden ermittelt

    Claire T. Friel earned a BSc in Biochemistry from the University of Glasgow, UK, and carried out her PhD work on protein folding kinetics in the laboratory of Sheena Radford at the University of Leeds, UK. In 2006, she joined the group of Jonathon Howard at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. There, she solved the ATP turnover cycle of the microtubule depolymerising Kinesin-13, MCAK, and developed an interest in the kinesin superfamily of molecular motors. Since 2011, Claire has held the position of Assistant Professor at the University of Nottingham, UK. The research goals of the Friel lab are to understand the relationship between the kinesin motor domain sequence and the many functional properties of the kinesin superfamily and to understand the molecular mechanisms of proteins that regulate microtubule dynamics.

    Contents

    Acknowledgements....................................................................................................ix

    Editor bio...................................................................................................................xi

    List of Contributors................................................................................................. xiii

    Chapter 1 Introduction to the Kinesin Superfamily..............................................1

    Hannah R. Belsham and Claire T. Friel

    Chapter 2 The Kinesin-1 Family: Long-Range Transporters.............................. 15

    David D. Hackney and Alison E. Twelvetrees

    Chapter 3 The Kinesin-2 Family: Transporters................................................... 33

    William O. Hancock

    Chapter 4 The Kinesin-3 Family: Long-Distance Transporters.......................... 41

    Nida Siddiqui and Anne Straube

    Chapter 5 The Kinesin-4 Family......................................................................... 55

    Claire T. Friel

    Chapter 6 The Kinesin-5 Family: Transporters and Creators.............................65

    Mary Popov, Alina Goldstein-Levitin and Larisa Gheber

    Chapter 7 The Kinesin-6 Family.........................................................................83

    Claire T. Friel

    Chapter 8 The Kinesin-8 Family.........................................................................87

    Tianyang Liu, Alejandro Peña, Fiona Shilliday, and

    Carolyn A. Moores

    Chapter 9 The Kinesin-13 Family: Specialist Destroyers.................................. 101

    Julie P. Welburn and Claire T. Friel

    Chapter 10 The Kinesin-14 Family...................................................................... 115

    Marcus Braun, Stefan Diez and Zdenek Lansky

    Chapter 11 The Kinesin-15 Family...................................................................... 135

    Hauke Drechsler, Jaspreet Singh Grewal and Andrew D. McAinsh

    Chapter 12 The Kinesin-16 Family...................................................................... 155

    Hanan M. Alghamdi and Claire T. Friel

    Chapter 13 Other Kinesin Families..................................................................... 161

    Claire T. Friel

    Chapter 14 Summary and Future Perspectives.................................................... 165

    Claire T. Friel

    Index....................................................................................................................... 167

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