Genetics, Genomics and Fish Phenomics

 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 5. August 2016
  • |
  • 272 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-805216-7 (ISBN)
 

Genetics, Genomics and Fish Phenomics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics.

The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions, with hhis volume focusing on genetics, genomics, and phenomics of fish.


  • Includes a critical analysis of future directions for the study of clinical genetics
  • Written and edited by recognized leaders in the field
  • Presents new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics
0065-2660
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 8,03 MB
978-0-12-805216-7 (9780128052167)
0128052163 (0128052163)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Genetics, Genomics and Fish Phenomics
  • Serial Editors
  • Genetics, Genomics and Fish Phenomics
  • Copyright
  • Contents
  • CONTRIBUTORS
  • One - Studying the Evolution of the Vertebrate Circadian Clock: The Power of Fish as Comparative Models
  • 1. INTRODUCTION
  • 1.1 What Are Circadian Clocks and Why Should We Study Them?
  • 1.2 Why Use Fish Genetic Models to Study Clocks?
  • 2. HOW DO FISH CLOCKS DIRECTLY SENSE LIGHT?
  • 2.1 Light-Inducible Gene Expression
  • 2.2 Peripheral Photoreceptors
  • 3. HOW DO FISH (AND CLOCKS) ADAPT DURING EVOLUTION UNDER PERPETUAL DARKNESS?
  • 3.1 Different Cave Environments
  • 3.2 Blind Clocks in Phreatichthys andruzzii
  • 3.3 Differences Between Surface and Cave Clocks in Astyanax
  • 3.4 Has the Astyanax Light-Response Altered Within Cave Strains?
  • 3.5 Astyanax in the Field
  • 3.6 Cavefish Sleep, Activity, and Metabolism
  • 4. OUTLOOK
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Two - Genomic and Transcriptomic Approaches to Study Cancer in Small Aquarium Fish Models
  • 1. INTRODUCTION
  • 2. CANCER MODELS IN FISH
  • 3. GENOMIC APPROACHES
  • 4. TRANSCRIPTOMIC APPROACHES
  • 4.1 Melanoma
  • 4.2 Rhabdomyosarcoma
  • 4.3 Hepatocellular Carcinoma
  • 5. OUTLOOK
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Three - Gal4 Driver Transgenic Zebrafish: Powerful Tools to Study Developmental Biology, Organogenesis, and Neurosc ...
  • 1. INTRODUCTION
  • 2. TOL2-MEDIATED TRANSGENESIS IN ZEBRAFISH
  • 3. THE GAL4-UAS SYSTEM IN ZEBRAFISH
  • 3.1 The Emergence of the Gal4-UAS System in Zebrafish
  • 3.2 Tol2-Mediated Gal4 Gene Trapping and Enhancer Trapping
  • 3.3 Additional Improvements in the Gal4-UAS System
  • 4. APPLICATIONS OF GAL4 DRIVERS
  • 4.1 Inhibition of Neuronal Activities via Targeted Expression of a Neurotoxin Gene
  • 4.2 Visualization of Neuronal Activities by Calcium Imaging
  • 4.3 Genetic Dissection of the Motor System
  • 4.4 The Architecture of Cerebellar Neural Circuits
  • 4.5 Proliferation and Differentiation of the Lateral Line System
  • 4.6 Spatiotemporal Functions of Notch Signaling
  • 5. CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Four - Whole-Organism Cellular Pathology: A Systems Approach to Phenomics
  • 1. INTRODUCTION
  • 1.1 Phenotype
  • 1.2 Phenomics and Phenome Projects
  • 1.3 Phenotype Omission Error
  • 1.4 Stereomicroscopy
  • 1.5 Molecular Imaging Versus Pan-Cellular Phenotyping
  • 1.6 Why Histological Phenotyping?
  • 2. LESSONS FROM LIGHT MICROSCOPY
  • 2.1 Early Tissue Phenotyping
  • 2.2 Histological Phenotyping in Medicine
  • 2.3 Histological Phenotyping in Zebrafish
  • 2.3.1 Method and Tool Development for Zebrafish Histology
  • 2.3.2 Lessons From Creating a Web-Based Histology Atlas
  • 2.3.3 Lessons From Phenotyping Zebrafish Using Histology
  • 2.3.3.1 From a Histological Mutagenesis Screen
  • 2.3.3.2 The Potential Utility of Volumetric Data
  • 2.3.3.3 From a Histological Screen of Existing Mutants Found by Stereomicroscopy
  • 3. WHOLE-ORGANISM CELLULAR PATHOLOGY AS A SYSTEMS APPROACH TO PHENOMICS
  • 3.1 The Need for Whole-Organism Cellular Pathology
  • 3.2 Whole-Organism Cellular Pathology Using Zebrafish
  • 4. CONCLUSIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Five - Evolutionary Genetics of the Cavefish Astyanax mexicanus
  • 1. INTRODUCTION
  • 2. THE ASTYANAX MEXICANUS SURFACE FISH AND CAVEFISH MODEL SYSTEM
  • 3. GENETICS IN THE PREMOLECULAR ERA
  • 3.1 Several Morphs, One Species
  • 3.2 Eyes and Pigmentation, and More
  • 3.3 Sleep Loss
  • 3.4 Space-Dependent Growth
  • 4. GENETIC DETERMINISM OF TROGLOMORPHIC TRAITS: INSIGHTS FROM A QUANTITATIVE TRAIT LOCI APPROACH
  • 4.1 Linkage Maps for quantitative trait loci Analyses
  • 4.2 Quantitative Trait Loci Clusters
  • 4.3 Refining Quantitative Trait Loci Analyses for Morphological and Behavioral Traits
  • 5. GENETIC DETERMINISM OF TROGLOMORPHIC TRAITS: A CANDIDATE GENE APPROACH
  • 5.1 Usual Suspects: Pax6 and Hedgehogs
  • 5.2 Lens Defects: Alpha-A Crystallin and Sox2
  • 5.3 The Quiet Fish: Monoamine Oxidase and the Cavefish Behavioral Syndrome
  • 5.4 MC4R and Metabolism
  • 6. GENOMICS AND EVOLUTIONARY MOLECULAR GENETICS
  • 6.1 Cavefish Transcriptomics
  • 6.2 Cavefish Genomics
  • 7. FUNCTIONAL GENETICS AND MOLECULAR TOOLS
  • 7.1 Resources
  • 7.2 Functional Genetics, Transgenesis, Genome-Editing
  • 8. CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Six - Transcriptional Regulation During Zygotic Genome Activation in Zebrafish and Other Anamniote Embryos
  • 1. ZYGOTIC GENOME ACTIVATION
  • 2. TWO PHASES OF ZYGOTIC GENOME ACTIVATION ARE REGULATED BY DISTINCT MECHANISMS
  • 2.1 Mid-Blastula Transition and the Major Phase of ZGA
  • 2.2 A Minor, First Wave of Transcription Precedes Global Genome Activation
  • 2.3 The Identity and Function of Early Zygotic Transcripts
  • 3. PROMOTER REGULATION MECHANISMS DURING ZYGOTIC GENOME ACTIVATION
  • 3.1 Changes to Chromatin State During ZGA
  • 3.2 Nucleosome Occupancy and Its Sequence Determinants
  • 3.3 Histone Variants as Placeholders for Regulatory Regions
  • 3.4 Demethylated Regions Appear on Promoters Before Genome Activation
  • 3.5 Posttranslational Histone Modifications at Promoters
  • 3.6 Maternal Control of ZGA by Pioneering Transcription Factors
  • 3.7 Paternal Contribution to the ZGA by Chromatin-Associated Epigenetic Mechanisms
  • 4. TRANSITIONS IN THE UTILIZATION OF TRANSCRIPTION MACHINERY AT ZGA
  • 4.1 Transcription Initiation Profiles and Corresponding Promoter Classification
  • 4.2 Maternal to Zygotic Transition in Transcription Factor Usage
  • 5. CONCLUSIONS AND PERSPECTIVES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Seven - The Zebrafish as Model for Deciphering the Regulatory Architecture of Vertebrate Genomes
  • 1. INTRODUCTION
  • 2. ENHANCERS ARE TRICKY TO FIND RELIABLY IN THE GENOME BY COMPUTATIONAL MEANS
  • 2.1 Chromatin Signatures as Guides to Enhancers on a Genome Scale
  • 2.2 Noncoding RNAs Linked to Enhancer Activity
  • 2.3 Functional Methods of Enhancer Detection
  • 2.4 Limitations of Global Methods
  • 3. HOW CAN THE ZEBRAFISH MODEL CONTRIBUTE?
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Eight - Transcriptomic Approaches in the Zebrafish Model for Tuberculosis-Insights Into Host- and Pathogen-specific ...
  • 1. INTRODUCTION
  • 2. ZEBRAFISH AS A MODEL FOR STUDYING IMMUNITY AND INFECTION
  • 3. MYCOBACTERIAL GRANULOMA DEVELOPMENT IN ZEBRAFISH
  • 4. TIMING OF EVENTS DURING THE M. MARINUM INFECTION PROCESS IN ZEBRAFISH EMBRYOS AND LARVAE
  • 5. ZEBRAFISH TRANSCRIPTOMICS
  • 6. THE PROFILES OF THE GENE EXPRESSION RESPONSE TO M. MARINUM INFECTION CAN BE DIVIDED INTO AN EARLY, MID, AND LATE PHASE
  • 7. EARLY AND LATE REGULATION OF TRANSCRIPTION FACTOR GENES
  • 8. REGULATION OF PRO-INFLAMMATORY CYTOKINE GENES
  • 9. INDUCTION OF MATRIX METALLOPROTEINASE GENES
  • 10. COLLECTIVE AND STRONGLY FLUCTUATING REGULATION OF LIPID METABOLISM AND TRANSPORT GENES
  • 11. EARLY INDUCTION OF COMPLEMENT COMPONENT GENES
  • 12. LATE-PHASE RESPONSE GENES
  • 13. HOST-SPECIFIC DETERMINANTS OF THE INNATE IMMUNE RESPONSE
  • 14. COMMON AND SPECIFIC PATHOGEN-DEPENDENT INNATE IMMUNE RESPONSES
  • 15. CONCLUDING REMARKS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Z
  • Color Plates
  • Back Cover

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