Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). The book explores the application of nanotechnology on the development of safe, effective, and reliable tools to prevent, diagnose, and treat NTDs.
Furthermore, Applications of Nanobiotechnology for Neglected Tropical Diseases includes multidisciplinary content, combining knowledge from biochemistry, medicinal chemistry, material sciences, pharmacology, and pharmaceutics. The book is divided into three main parts, each outlining one major type of approach: (1) nano-based approaches for prevention, (2) nano-diagnostics and detection, and (3) nanotherapeutics. Each part contains chapters that delve into the different applications of the type of approach being presented in that part. A discussion of other approaches against NTD follows these three parts. This book is remarkable in its ability to encompass and thoroughly explain the latest techniques in nanobiotechnology, from basic research to patient-oriented investigation.
Offers a broad overview of nanobiotechnology applied to the prevention, diagnostics, and treatment of NTDs
Presents cutting-edge recent advances in nanobiotechnology, focusing on diseases reported by the World Health Organization's NTDs Roadmap (e.g., leishmaniasis, malaria, schistosomiasis, filariasis, etc.)
Provides a deep discussion about ground-breaking approaches designed to meet the medical needs of patients suffering from NTDs
Gives examples of multidisciplinary investigations into NTDs, from research labs to clinics
Part I: Nano-based approaches for prevention of NTD
1. Experimental vaccination with nanoparticles containing Escherichia coli virulence factors 2. Vaccine as immunotherapy for leishmaniasis
3. Polymeric particles as a delivery agent for malarial vaccines
Part II: Nano-Diagnostics and Detection of NTD 4. The use of nano-enabled technologies to diagnose dengue virus infections 5. Multiplexed detection with nanodiagnostics 6. Nanosensor for the detection of malaria parasite
Part III: Nanotherapeutics for NTD 7. Developing effective amphotericin B delivery systems for fungal infections 8. Development of nanocarriers for innovative antimalarial combination strategies 9. Nanomedicines against Chagas disease 10. Nanoformulations of old and new antimalarial drugs 11. Drug repurposing and nanoparticles: New strategies against leishmaniasis 12. Nanoformulations for new compounds against leishmaniasis 13. Improving the miltefosine efficacy against leishmaniasis by using nanoassemblies made from surfactants or amphiphilic antimony (V) complex 14. Trendings of amphotericin B-loaded nanoparticles as valuable chemotherapeutic approaches against leishmaniasis 15. Nanopharmaceuticals to target antifilarials: Administration of old age drugs in a novel way 16. Lipid nanoparticles for the treatment of neglected tropical diseases 17. Experimental treatment of Schistosomiasis mansoni using praziquantel-free and encapsulated into nanostructures
Part IV: Other approaches for NTD 18. Bionanocomposite assembly with larvicidal activity against Aedes aegypti 19. Microfilaricidal efficacy of silver nanoparticles 20. Self-assembled nanocarriers as biotechnology approach to antivenom immunotherapy 21. Novel processes combining natural products and synthetic materials for developing nanolarvicides 22. Development of eco-friendly nano-mosquitocides against arboviruses vectors 23. Systems biology and bioinformatics approaches in leishmaniasis 24. May nanoparticles offer chances to avoid the development of insecticide resistance in mosquitoes?