Thermophiles and hyperthermophiles exhibit great biotechnological potential, as they can be utilized in processes which require higher temperatures. This book comprehensively deals with all the aspects of thermophiles, starting from the source of these organisms to their latest applications. In addition it presents a compilation of all compounds produced by various thermophilic microorganisms. Due to their application in everyday life, the demands of enzymes that can work at higher temperature have been increasing. In order to keep pace with the increasing demand the industries have to search novel thermophiles producing their product of interest. Hence, this book will be of value for industries working on various biochemical products produced by these thermophiles as well as for scientists and research scholars working on microbiology and products derived from microorganisms.
Dr. Jujjavarapu Satya Eswari is currently working as an Assistant professor in Department of Biotechnology at National Institute of Technology (NIT), Raipur, India. She completed her PhD from IIT Hyderabad / IICT Hyderabad (CSIR lab). She also pursued her research in the areas of bioinformatics and bioprocess and product development. She gained pioneering expertise in the application of mathematical and engineering tools in biotechnological processes. Her fields of specializations include bioinformatics, biotechnology, and process modeling, evolutionary optimization and artificial intelligence. She has more than 35 publications in SCI/Scopus indexed journals and 35 proceedings in international and national conferences. Her research contributions have received wide global citations. She has also published 6 book chapters and 4 books (currently in press) with international publishers. Dr.J. Satya eswari completed 2 sponsored and currently 1 on-going project. She has a teaching experience of more than 7 years along with a research experience of 3 years. She has conducted various short-term courses on bioprocess development, and soft computing and intelligent techniques. She has delivered invited lectures in various institutes. She visited three countries for international conferences. She has guided more than 47 B.Tech and post-graduate students and is currently supervising 5 Ph.D. students, a project assistant and 7 B.Tech students. She is an active participant in both academic and research activities. She has reviewed various research articles in 20 international journals. She is an active member of various organisations. She has received early career research (ECR) award by DST, IEI young engineer award, Venus Outstanding woman in engineering and DK international best faculty award (2018).
Dr. Ramkrishna Sen is a Professor (Bioprocess Engineering) and currently, the Head, Department of Biotechnology and a Joint-Faculty, P K Sinha Center for Bioenergy & Renewables, IIT Kharagpur. He served as a Fulbright Visiting Professor in Columbia University, New York, USA. Prof. Sen also worked as an Assistant Professor in BITS, Pilani for about 2 years and as Manager (R&D-Biotech) in Cadila Pharmaceuticals Ltd., Ahmedabad for about 3 years. Prof. Sen has been engaged in R&D activities in the areas of Healthcare, Energy, Environment & Water, with a focus on Green Process & Product Development in Microalgal-Microbial Biorefinery models. So far, 21 students have completed their Ph.D under his guidance. Currently 18 Ph.D students including 2 in foreign Universities are working under his supervision. He has about 230 publications in international and national journals, books and conference proceedings and 13 patent applications including 3 international to his credit. Prof. Sen completed 24 sponsored and consultancy projects and has 9 on-going projects. He published a book 'Biosurfactants' (Springer-USA). Prof. Sen has been honoured with the Distinguished Alumni Award (Jadavpur University; 2017); Fulbright Visiting Professor Fellowship (USA; 2013-14); UKIERI Award for Academic Visits (UK, 2007); and National Award for Technology Innovation, Government of India (2012). He is a life member of Indian Institute of Chemical Engineers (IIChE) and member of European and Asian Federations of Biotechnology. Prof. Sen administered as Vice-Chairman and Chairman (GATE & JAM), IIT Kharagpur from 2015-18.
Ms. Swasti Dhagat is currently a research scholar in Department of Biotechnology at National Institute of Biotechnology. She has done her M.Tech in biotechnology from Birla Institute of Technology and Science (BITS)-Pilani, Hyderabad and B.Tech in biotechnology from Banasthali University. She has seven publications in international peer-reviewed journals, few conference proceedings in international and national conferences and a book which is currently in press. She has pursued research from Council of Scientific and Industrial Research (CSIR) laboratories in India in the areas of microbiology and environmental biotechnology.
1.1.Diversity of microorganisms.
1.2.Psychrophilic microorganisms and their habitat with examples.
1.3.Implications of Mesophilic microorganisms.
1.4.Habitat and diversity of Thermophilic microorganisms.
1.5.Hyperthermophilic microrganisms: challenges to the living world.
1.6.Biotechnology and bioprocess engineering of thermophiles
2: Thermophilic enzymes or heat stable enzymes: biochemical properties and commercial applications.
2.1.Oxidoreductases enzyme production from Thermophilic hosts.
Thermophiles and their hot environment for Transferases production.
2.3.Hydrolytic enzymes and their thermophilic microbial sources.
2.4.Lyases from thermophiles and their applications.
2.5.Biotechnological potential of Isomerases from thermophilic microorganisms.
2.6.Thermophiles for the production of Ligases, molecular glue of biotechnology
Recombinant enzyme production in thermophilic hosts
2.9.Immobilization of thermophilic enzymes
3: Thermophilic amino acids and proteins: current research and applications
3.1. Thermal stability of proteins
3.2. Factors affecting for thermal stability of proteins
3.3. Phenomena of protein folding system in Thermophiles
3.4. Significance of thermophilic proteins at Industrial level
3.5. Molecular mechanism of thermostable proteins from thermophiles
3.6. Thermophilic amino acids: building blocks of thermophilic proteins
3.7. Bioprocess considerations for thermophilic amino acids and
4: Organic compounds by thermophiles
4.1. Organic Acids from thermophilic microorganisms: Butyric acid, citric acid, lactic acid, acetic acid, 2,3-Butanediol
4.2. Production of Antimicrobial agents from thermophilic microbial sources:
4.3. Thermophilic microbial sources for the production of Alcohols: Bio ethanol
4.4. Growth kinetics during batch and continuous mode of operation
5: Other compounds and products from thermophiles
5.1. Lipopeptides by thermophiles: Biosurfactant
5.2. Glycolipids by thermophiles : Glycopilid, Rhamnolipid
5.3. Fatty acids and Natural Lipids from The thermophiles
5.4. Bio emulsifiers production from the thermophiles
5.5. Kinetic studies and bioprocess considerations in secondary metabolites
6: Applications of thermophilic microorganisms
6.1. Thermophiles as key players in environmental bioremediation
6.2. Role of thermophiles for the production of Biofuels
6.3. Importance of thermophiles in bio refinery
6.4. Significance of thermophiles in detergent industries
6.5. Potential of t
hermophiles in beverage industries
6.6. Modeling and optimization studies of bioprocesses
7. Problems and challenges while handling thermophiles
7.1. Handling and culturing of thermophiles
7.2. Maintenance and storage thermophiles at high temperature
7.3. Contamination of bio processes due to thermophiles