Gene-Environment Interactions in Psychiatry

Nature, Nurture, Neuroscience
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 26. Juli 2016
  • |
  • 366 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
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978-0-12-801783-8 (ISBN)
 

Gene-Environment Interactions in Psychiatry: Nature, Nurture, Neuroscience begins with the basic aspects of gene-environment studies, such as basic genetics, principles of animals modeling, and the basic processes of how environmental factors affect brain and behavior, with part two describing the most important psychiatric disorders in detail.

Each chapter has a similar structure that includes a general description of the disorder that is followed by an analysis of the role of genes and how they are affected by environmental factors. Each chapter ends with a description of the most relevant animal models, again focusing on gene-environment interactions.

The book concludes with a critical evaluation of the current research and an outlook for the (possible) future, offering a vignette into the fascinating world of nature, nurture, and neuroscience.


  • Written to provide in-depth basic knowledge on gene-environment interactions for graduate students, postgraduate students, clinicians, and scientists
  • Includes descriptions of the major psychiatric disorders
  • Provides detailed descriptions of animal models and basic genetic information
  • Presents well-illustrated color figures to explain complex features in a simple manner


Dr. Ellenbroek has over 30 years of experience in the field of behavioural neurosciences especially in relation to animal models for schizophrenia and addiction. He has published over 135 papers in peer-reviewed international journals, including many reviews, also on the topic on gene * environment interactions. He has been an invited speaker at over 30 conferences in the last 10 years has co-authored over 35 book chapters. In addition, he is currently co-Editor-in-Chief of 'Current Topics in Behavioural Neurosciences" and Reviews Editor of 'Behavioural Pharmacology".
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 19,16 MB
978-0-12-801783-8 (9780128017838)
012801783X (012801783X)
weitere Ausgaben werden ermittelt
  • Cover
  • Title Page
  • Copyright Page
  • Dedication
  • Contents
  • Preface
  • Section I - General Introduction
  • Chapter 1 - Introduction
  • Introduction
  • Gregor Johann Mendel
  • Mendel's first law of inheritance: the law of segregation
  • Mendel's second law of inheritance: the law of independent assortment
  • The legacy of Mendel's work
  • Criticism of Mendel's work
  • The search for the Mendelian elements
  • The sex chromosomes
  • Beyond Mendel: the historical development of molecular genetics
  • A brief history of behavioral genetics
  • References
  • Chapter 2 - The Genetic Basis of Behavior
  • Introduction
  • The molecular structure of DNA
  • DNA synthesis and replication
  • The structure of the genome
  • DNA transcription
  • The structure of genes
  • mRNA processing
  • mRNA translation
  • Genetic alterations
  • Single Nucleotide Variations
  • Tandem repeat sequences
  • Triplet repeats
  • Variable Number Tandem Repeats (VNTRs)
  • Short insertions and deletions (indels)
  • Copy number variations (CNVs)
  • Chromosomal variations
  • References
  • Chapter 3 - Animal Modelling in Psychiatry
  • Introduction
  • Animal models
  • Screening Models
  • Pharmacological Bioassays
  • Neuroscience Bioassays
  • Simulation Models
  • Validating animal models
  • Genetic modulation in animals
  • Forward Genetic Approaches
  • Reverse Genetic Approaches
  • Random Techniques
  • Targeted Techniques
  • References
  • Chapter 4 - The Environmental Basis of Behavior
  • Introduction
  • Environmental factors
  • Timing
  • The prenatal period
  • The perinatal period
  • The postnatal period
  • The adolescent period
  • Evaluating the role of environmental factors in animals
  • Developmental differences between rodents and humans
  • References
  • Chapter 5 - Environment Challenges and the Brain
  • Introduction
  • Early environmental challenges and structural brain changes
  • Early environmental challenges and the immune system
  • Early environmental challenges and the hypothalamic pituitary adrenal (HPA) axis
  • Early environmental challenges and neurotransmitter changes
  • Early environmental challenges and epigenetic changes
  • The molecular structure of chromosomes
  • The histone family of proteins
  • Epigenetic mechanisms - introduction
  • Modification at the level of the nucleotides
  • DNA Methylation
  • RNA Interference
  • Chemical modification at the level of the histones
  • Histone Acetylation
  • Histone Phosphorylation
  • Histone Methylation
  • Additional Histone Modifications
  • The Complexity of Histone Modifications
  • Structural changes at the level of the nucleosome
  • Early environmental challenges and epigenetic changes
  • The Environment and Chromatin Modification
  • The Environment and Histone Modification
  • The Environment and Chromatin Remodeling
  • References
  • Section II - Gene-Environment Interactions in Psychiatric Disorders
  • Chapter 6 - Drug Addiction
  • Introduction
  • Diagnosis and symptoms
  • The Epidemiology of drug addiction
  • The neurobiology of drug addiction
  • The pharmacological treatment of drug addiction
  • Replacement Therapies
  • Other Therapies
  • The aetiology of drug addiction
  • Genetic Factors Contributing to Drug Addiction
  • Moderation of the Effects of Genes by Environmental Factors
  • Animal models for drug addiction
  • Measuring Addiction-Like Features in Animals
  • Genetic Models of Drug Addiction
  • Moderation of the Effects of Genes by Environmental Factors
  • References
  • Chapter 7 - Affective Disorders
  • Introduction
  • Major depressive disorder
  • Diagnosis and Symptoms
  • The Epidemiology of MDD
  • The Neurobiology of MDD
  • The Pharmacological Treatment of MDD
  • The Aetiology of MDD
  • Genetic Factors Contributing to MDD
  • Moderation of the Effects of Genes by Environmental Factors
  • Animal models for MDD
  • Measuring MDD-Like Features in Animals
  • Genetic Models for MDD
  • Moderation of the Effects of Genes by Environmental Factors
  • Bipolar disorder (BP)
  • Diagnosis and Symptoms
  • The Epidemiology of BP
  • The Neurobiology of BP
  • The Pharmacological Treatment of BP
  • The Aetiology of BP
  • Genetic Factors Contributing to BP
  • Moderation of the Effects of Genes by Environmental Factors
  • Animal models for BP
  • Measuring BP-Like Features in Animals
  • Genetic Models of BP
  • Moderation of the Effects of Genes by Environmental Factors
  • References
  • Chapter 8 - Childhood Disorders
  • Introduction
  • Attention Deficit Hyperactivity Disorder
  • Diagnosis and Symptoms
  • The Epidemiology of ADHD
  • The Neurobiology of ADHD
  • The Pharmacological Treatment of ADHD
  • Stimulant Drugs
  • Nonstimulant Drugs
  • The Aetiology of ADHD
  • Genetic Factors Contributing to ADHD
  • Moderation of the Effects of Genes by Environmental Factors
  • Animal Models for ADHD
  • Measuring ADHD-Like Features in Animals
  • Genetic Models for ADHD
  • Moderation of the Effects of Genes by Environmental Factors
  • Autism Spectrum Disorders
  • Diagnosis and Symptoms
  • The Epidemiology of ASD
  • The Neurobiology of ASD
  • The Pharmacological Treatment of ASD
  • The Aetiology of ASD
  • Genetic Factors Contributing to ASD
  • Moderation of the Effects of Genes by Environmental Factors
  • Animal Models for ASD
  • Measuring ASD-Like Features in Animals
  • Genetic Models of ASD
  • Moderation of the Effects of Genes by Environmental Factors
  • References
  • Chapter 9 - Schizophrenia
  • Introduction
  • Diagnosis and symptoms
  • The Epidemiology of Schizophrenia
  • The Neurobiology of Schizophrenia
  • The Pharmacological Treatment of Schizophrenia
  • The Aetiology of Schizophrenia
  • Genetic Factors Contributing to Schizophrenia
  • Moderation of the Effects of Genes by Environmental Factors
  • Animal models for Schizophrenia
  • Measuring Schizophrenia-Like Features in Animals
  • Genetic Animal Models for Schizophrenia
  • Moderation of the Effects of Genes by Environmental Factors
  • References
  • Chapter 10 - Conclusions and the Road Ahead
  • Introduction
  • The genetic revolution and psychiatry
  • The genetic analysis is incomplete
  • Genetic effects are moderated by the environment
  • Psychiatric disorders are heterogeneous
  • Looking toward the future
  • The future of animal modelling
  • Conclusion
  • References
  • Abbreviations
  • Index
  • Back cover

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