The second edition of this well-received volume has been revised and updated to reflect the advances in pathological classification and molecular epidemiology of diffuse low-grade gliomas (DLGG) in adults and offers an updated review on individualized therapies. This book presents the latest research pertaining to the diagnosis, genetics, therapy and management of DLGGs. It extensively covers recent research on the natural history of DLGGs and their interaction with the brain and reviews the new diagnostic and therapeutic strategies which increase survival and quality of life of the patient.
New topics covered are the management of DLGGs during pregnancy, functional rehabilitation of patients with DLGG and the onco-functional balance in DLGG, among others. The reader will have the opportunity to gain insight in both clinical and basic science aspects of this type of tumor and learn about the application of novel imaging techniques such as diffussion tensor imaging.
Edited by a leading expert in the field and authored by a team of recognised specialists, this book is a valuable resource for medical oncologists, neuro-oncologists and neurologists.
Hugues Duffau, after his residency and habilitation 2002 at the University Paris VI, became Professor 2006 and Head of the Department of Neurosurgery, Montpellier, France in 2007.
He is one of the leading experts in low grade glioma surgery and well known for his holistic view of the brain and his pursuit for changing paradigms in neurooncological surgery. For him, a deep understanding of anatomy, functional imaging, intraoperative mapping and neuropsycological assessments is mandatory to open new doors to personalized therapeutic strategies for patients.
With 227 publications and four books, he is in the editorial board of five journals and member of several neurosurgical and neuroncological societies.
Foreword.- Introduction: Diffuse Low Grade Gliomas (DLGG).- Epidemiology.- Molecular Epidemiology and DLGG.- New Pathological Classification.- Towards an Intermediate Grade in Glioma Classification.- Genetics of DLGG.- Molecular Classification.- Pathogenesis of DLGG.- Mechanisms of DLGG migration.- Genomics of DLGG.- DLGG-associated stem cells.- Molecular imaging .- Clinical Presentation.- Epilepsy and DLGG.- Quality of Life in patients with DLGG.- Oncological and Metabolic MRI.- Positron Emission Tomography.- Dynamics of DLGG and Clinical Implications.- Natural History and Spontaneous Prognostic Factors.- Language, Cognitive and Emotional Evaluation.- Functional MRI in DLGG.- Diffusion Tensor Imaging in DLGG.- Magnetoencephalography and Functional Connectivity in DLGG.- Interactions between DLGG and Neuroplasticity.- Surgery: Oncological Considerations.- Surgery: Functional Considerations.- Chemotherapy^tion in Patients with DLGG.- New Individualized Strategies.- Pregnancy and DLGG.- Social cognition and DLGG.- Biomathematical Modeling of the DLGG Behavior.- Towards a Resection Probability Map.- The Onco-functional Balance in DLGG.- The Origins of DLGG.- DLGG and Cognitive Neurosciences.