ContributorsPrefaceIIntroduction1. Introduction to antibiotic therapyAmal Kumar Dhara and Amit Kumar Nayak1 Introduction2 Bacterial infection3 Antibiotic era4 Challenges in the development of antibiotics5 Classes of antibiotics and their therapeutic spectrum6 ß-Lactam antibiotics7 Aminoglycoside antibiotics8 Chloramphenicol and tetracyclines9 Macrolide antibiotics10 Lincosamide and glycopeptide antibiotics11 Polypeptide antibiotics12 Antifungal antibiotics13 Antitubercular antibiotics14 Toxicity of antibiotics15 Antimicrobial resistance16 Prospect of probiotics and natural products17 ConclusionReferencesIIMicrobial infection and antibiotics development2. Bacterial infections: Types and pathophysiologyV.T. Anju, Siddhardha Busi, Mahima S. Mohan, and Madhu Dyavaiah1 Infection: An overview2 Bacterial infections and mechanism of pathogenesis3 Types of bacterial infections and pathophysiology4 ConclusionsReferences3. Antibiotics role in past and present: A challenge to find new possibilites in developmentKumar Bhavna, Deepika Raina, Shradha Singh Raghav, Manmohan Singhal, Neeraj Kumar Sethiya, Samir Bhargava, and Abhijeet Ojha1 Introduction2 Mechanisms of resistance to antibiotics3 Antimicrobial chemotherapy4 The golden era of antibiotics5 ConclusionReferences4. Challenges in the development of novel antibioticsDavid Elder1 Introduction2 Target product profiles for new antibacterials3 Developing novel antibiotics4 Case studies: Development of novel antibiotics5 The role of public-private partnerships (PPPs) in developing new antibiotics6 ConclusionsReferencesIIIAntibiotics and therapeutics5. Beta-lactam antibioticsCarlos Barreiro, Sonia Marti¿nez-Cämara, Carlos Garci¿a-Estrada, Manuel de la Torre, and Jose L. Barredo1 Introduction2 Beta-lactam antibiotics: Types, structure, and mechanism of action3 Penicillins and cephalosporins: Discovery and biosynthetic pathways4 Resistances: Mechanism and clinical relevance5 Omics in the development of beta-lactams6 Future outlookAcknowledgmentsReferences6. Aminoglycoside antibioticsJulia Revuelta and Agatha Bastida1 Introduction2 Targeting RNA with AGAs3 Aminoglycoside resistance4 Toxicity5 Pharmacokinetics and pharmacodynamics6 Development of second-generation AGAs7 Aminoglycoside-based biomaterials8 Outlook and future perspectivesReferences7. Chloramphenicol and tetracycline (broad spectrum antibiotics)Manmohan Singhal, Mohit Agrawal, Kumar Bhavna, Neeraj Kumar Sethiya, Samir Bhargava, Komal Satish Gondkar, Kumud Joshi, Vijay Singh Rana, Jagannath Sahoo, and Mandeep Kumar Arora1 Introduction2 Tetracyclins3 Mode of action of tetracyclines4 Tetracycline resistance with mechanisms in biochemistry and genetics5 Chloramphenicol6 Structural-activity relationship7 Chloramphenicol resistance8 Combination effect of chloramphenicol with other antibiotics9 ConclusionFurther reading8. Macrolide antibioticsManmohan Singhal, Mohit Agrawal, Kumar Bhavna, Komal Satish Gondkar, Neeraj Kumar Sethiya, Kumud Joshi, Ritik Kumar, Uddipak Rai, Samir Bhargava, and Vijay Singh Rana1 Introduction2 The binding site of macrolide3 Mode of action4 Classification of macrolide antibiotics5 Administration6 Side effects7 Contradictions8 Monitoring9 Toxicity10 Resistance11 ConclusionFurther reading9. Lincosamide and glycopeptide antibioticsIjaz Hussain, Tania Jabbar, Asma Naureen, Sadaf-Ul-Hassan, Amjad Hussain, Muhammad Rehan Hasan Shah Gilani, Naseem Abbas, and Syed Ali Raza Naqvi1 Introduction2 Structures of lincosamides and glycopeptides antibiotics3 Mechanism of action4 Bacterial resistance5 Semisynthetic glycopeptide antibiotics6 Biological activity and medicinal importance7 ConclusionReferences10.
