Mechanisms of Morphogenesis

 
 
Academic Press
  • 2. Auflage
  • |
  • erschienen am 18. Februar 2013
  • |
  • 414 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-415757-6 (ISBN)
 

Morphogenesis is the set of processes that generate shape and form in the embryo--an important area within developmental biology. An exciting and up-to-the-minute account of the very latest research into the factors that create biological form, Mechanisms of Morphogenesis, second edition is a text reference on the mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi.

By combining hard data with computer modeling, Mechanisms of Morphogenesis, second edition equips readers with a much broader understanding of the scope of modern research than is otherwise available. The book focuses on the ways in which the genetic program is translated to generate cell shape, to direct cell migration, and to produce the shape, form and rates of growth of the various tissues. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and pointers to future


* Includes over 200 four-color figures
* Offers an integrated view of theoretical developmental biology and computer modelling with laboratory-based discoveries
* Covers experimental techniques as a guide to the reader
* Organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems
  • Englisch
  • San Diego
Elsevier Science
  • 20,94 MB
978-0-12-415757-6 (9780124157576)
0124157572 (0124157572)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Mechanisms of Morphogenesis
  • Copyright
  • Dedication
  • Contents
  • Preface
  • A Note on References
  • Section I - Introductory Section
  • Chapter 1 - Introduction: The Aims and Structure of This Book
  • Reference List
  • Chapter 2 - Key Principles of Morphogenesis
  • THE IDEA OF 'MECHANISM'
  • EMERGENCE
  • EMERGENCE, TRAP-DOOR PROCESSES AND THE DANGERS OF POST-HOC REASONING
  • FEEDBACK, SELF-ASSEMBLY AND ADAPTIVE SELF-ORGANIZATION
  • Reference List
  • Chapter 3 - The Power and Limitations of Self-Assembly
  • INTRODUCTION TO SELF-ASSEMBLY
  • SELF-ASSEMBLY OF BILAYERED MEMBRANES
  • ONE-DIMENSIONAL SELF-ASSEMBLY: ACTIN
  • ONE-DIMENSIONAL SELF-ASSEMBLY: COLLAGEN
  • THREE-DIMENSIONAL SELF-ASSEMBLY: SIMPLE VIRUSES
  • QUALITY CONTROL IN SELF-ASSEMBLING STRUCTURES
  • LIMITATIONS TO SELF-ASSEMBLY
  • Reference List
  • Section II - Cell Shape and Cell Morphogenesis
  • Chapter 4 - Morphogenesis of Individual Cells: A Brief Overview
  • FLATTENING AND ELONGATION OF CELLS
  • PRODUCTION OF CELL PROCESSES
  • CELL FUSIONS
  • CELL CAVITATION
  • CHANGES IN CELL SHAPE CAN DIRECTLY DRIVE MORPHOGENESIS OF TISSUES
  • Reference List
  • Chapter 5 - Animal Cell Shape: The Importance of the Cytoskeleton
  • TENSEGRITY
  • BUILDING AND PLACEMENT OF TENSILE MICROFILAMENTS
  • ADAPTIVE SELF-ORGANIZATION OF THE MICROFILAMENT TENSION SYSTEM
  • ASSEMBLY OF THE MICROTUBULE SYSTEM
  • FORMATION OF SPECIAL STRUCTURES: ACTIN-BASED CELL PROTRUSIONS
  • Reference List
  • Chapter 6 - Cellular Morphogenesis in Plants
  • DIFFUSE CELL ELONGATION IN PLANTS
  • FOCUSED CELL GROWTH: ROOT HAIRS, POLLEN TUBES AND TRICHOMES
  • Reference List
  • Section III - Cell Migration
  • Chapter 7 - Cell Migration in Development: A Brief Overview
  • MORPHOGENESIS BY COALESCENCE OF DISPERSED CELLS
  • TRANSLOCATION OF GROUPS OF CELLS FROM ONE PLACE TO ANOTHER
  • DISPERSAL OF CELLS FROM ONE SITE TO THE REST OF THE BODY
  • MIGRATION BY CELL PROCESSES
  • Reference List
  • Chapter 8 - The Nano-Machinery of Locomotion
  • PROTRUSION: THE ACTIN-BASED NANO-MACHINERY OF THE LEADING EDGE
  • FILOPODIA IN CELL CRAWLING
  • CONTROL OF FORMATION OF LAMELLIPODIA/FILOPODIA
  • ADVANCE OF THE CELL BODY
  • RETRACTION OF THE REAR OF THE CELL
  • KEY POINTS TO TAKE FORWARD INTO THE NEXT CHAPTERS
  • Reference List
  • Chapter 9 - Guidance by Chemotaxis
  • THE CHEMOTACTIC GRADIENT
  • READING THE CHEMOTACTIC GRADIENT
  • LINKING THE INTERNAL REPRESENTATION OF THE EXTERNAL GRADIENT TO MOTILITY
  • HOW GOOD A MODEL IS D. DISCOIDEUM FOR OTHER SPECIES?
  • CHEMOREPULSION
  • MULTIPLE SOURCES OF CHEMOREPELLANT CAN DEFINE A PATHWAY IN A WAY THAT MULTIPLE SOURCES OF CHEMOATTRACTANT CANNOT
  • THE USEFULNESS OF NOISE TO DECISION-MAKING BY MIGRATING CELLS
  • INTEGRATION OF CHEMOTAXIS AND CONTACT GUIDANCE
  • Reference List
  • Chapter 10 - Guidance by Galvanotaxis
  • CELL MOVEMENT IN RESPONSE TO ELECTRIC FIELDS
  • ELECTRIC FIELDS IN LIVING SYSTEMS
  • Reference List
  • Chapter 11 - Guidance by Contact
  • HAPTOTAXIS
  • DUROTAXIS: GUIDANCE OF CELLS BY GRADIENTS OF MECHANICAL COMPLIANCE
  • ATTRACTION BY CONTACT-DRIVEN CELL SIGNAL TRANSDUCTION
  • PATHWAYS OF ATTRACTIVE MOLECULES IN THE EMBRYO
  • GUIDANCE OF CELLS BY ALIGNED FIBRES
  • GUIDANCE BY INHIBITION OF LOCOMOTION
  • Reference List
  • Chapter 12 - Waypoint Navigation in the Embryo
  • WAYPOINT NAVIGATION BY GERM CELLS IN DROSOPHILA MELANOGASTER
  • WAYPOINT NAVIGATION BY GROWTH CONES
  • DENSE ARRAYS OF WAYPOINTS MAKE PATHWAYS
  • THE MANY WAYPOINTS OF THE VERTEBRATE VISUAL SYSTEM
  • Reference List
  • Chapter 13 - Cooperative Migration of Mesenchymal Cells
  • WHY MIGRATE AS A COLLECTIVE?
  • CASE STUDY: COLLECTIVE CELL MIGRATION BY THE NEURAL CREST
  • CASE STUDY: THE ROSTRAL MIGRATORY STREAM
  • CONCLUDING REMARKS
  • Reference List
  • Chapter 14 - Condensation of Cells
  • CONDENSATION THROUGH ENHANCED CELL ADHESION
  • CONDENSATION BY ELIMINATION OF INTERSTITIAL MATRIX
  • Reference List
  • Section IV - Epithelial Morphogenesis
  • Chapter 15 - The Epithelial State: a Brief Overview
  • THE MAKING OF AN EPITHELIUM
  • THE FORCES THAT SHAPE AN EPITHELIUM
  • Reference List
  • Chapter 16 - Neighbour Exchange and Convergent Extension
  • Reference List
  • Chapter 17 - Closure of Holes
  • DORSAL CLOSURE IN DROSOPHILA MELANOGASTER
  • WOUND HEALING IN THE EMBRYO
  • Reference List
  • Chapter 18 - Invagination and Evagination: The Making and Shaping of Folds and Tubes
  • INVAGINATION
  • MODELS FOR AXIAL INVAGINATION (1): APICAL CONSTRICTION
  • MODELS FOR AXIAL INVAGINATION (2): MATRIX MECHANICS
  • MODELS FOR AXIAL INVAGINATION (3): AN ATTEMPTED SYNTHESIS
  • ORTHOGONAL INVAGINATION: NEURAL TUBE FORMATION IN VERTEBRATES
  • INVAGINATION WITHOUT TUBE FORMATION
  • EVAGINATION OF IMAGINAL DISCS
  • Reference List
  • Chapter 19 - Epithelial Fusion
  • TRACHEAL FUSION IN DROSOPHILA MELANOGASTER
  • EPITHELIAL FUSION IN PALATE DEVELOPMENT
  • Reference List
  • Chapter 20 - Epithelial Branching
  • BRANCHING BY SPROUTING
  • SWITCHING BETWEEN MODES OF BRANCHING
  • HOW CONSERVED IS BRANCHING BY SPROUTING?
  • BRANCHING BY CLEFTING
  • PATTERNING THE BRANCHING TREE
  • INTUSSUSCEPTIVE BRANCHING
  • AUTOMATIC VERSUS PLANNED ARCHITECTURE IN BRANCHING SYSTEMS
  • Reference List
  • Chapter 21 - Boundaries to Epithelial Movement
  • AVOIDING THE PROBLEM OF BOUNDARY CONTROL
  • PROTECTING A BORDER BY CONTROLLING MIGRATION
  • THEORY 1: BOUNDARY FORMATION BY DIFFERENTIAL ADHESION (CAUTION!)
  • THEORY 2: BOUNDARY FORMATION BY TENSION
  • REDUCED CELL PROLIFERATION: AN AID TO BOUNDARY STABILITY?
  • Reference List
  • Section V - Morphogenesis by Cell Proliferation and Death
  • Chapter 22 - Growth, Proliferation and Death: A Brief Overview
  • CELL PROLIFERATION IS CONTROLLED AT SEVERAL SCALES
  • CONTROL OF CELL PROLIFERATION
  • A BRIEF INTRODUCTION TO THE CELL CYCLE
  • LOCAL CONTROL OF CELL PROLIFERATION
  • TISSUE-SCALE CONTROL OF PROLIFERATION: A MECHANISM FOR KEEPING DIFFERENT CELL POPULATIONS IN BALANCE
  • LARGE-SCALE CONTROL OF CELL PROLIFERATION
  • INTERPLAY BETWEEN GLOBAL AND ORGAN-SPECIFIC SIGNALS
  • PLANTS SHOW A DIRECT CONNECTION BETWEEN GROWTH AND MORPHOGENESIS
  • Reference List
  • Chapter 23 - Morphogenesis by Orientated Cell Division
  • ORIENTATION OF THE MITOTIC SPINDLE
  • ADAPTIVE SELF-ORGANIZATION OF MITOTIC ORIENTATION AND HERTWIG'S RULE
  • ORIENTATED CELL DIVISION IN PLANTS
  • Reference List
  • Chapter 24 - Morphogenesis by Elective Cell Death
  • COMPETITION, DEATH AND THE TROPHIC THEORY
  • ANOIKIS AND ERROR CORRECTION
  • ELECTIVE CELL DEATH IN PLANTS
  • DEATH FOR LIFE
  • Reference List
  • Section VI - Modelling Morphogenesis
  • Chapter 25 - Modelling Morphogenesis: A Brief Overview
  • THE PURPOSES OF MODELLING
  • BROAD STRATEGIES FOR MODELLING: MATHEMATICAL VERSUS SYNTHETIC BIOLOGICAL
  • Reference List
  • Chapter 26 - Mechanical and Mathematical Models of Morphogenesis
  • PHYSICAL MODELS
  • COMPUTER MODELS OF EPITHELIAL MORPHOGENESIS
  • CONCLUDING REMARKS
  • Reference List
  • Chapter 27 - Modelling Using Living Cells: Tissue Engineering and Synthetic Morphology
  • TISSUE ENGINEERING AS A TECHNIQUE FOR MODELLING MORPHOGENESIS
  • SYNTHETIC MORPHOLOGY
  • Reference List
  • Section VII - Conclusion and Perspectives
  • Chapter 28 - Conclusions and Perspectives
  • PROVISIONAL CONCLUSIONS FROM THE MECHANISMS DESCRIBED IN FOREGOING CHAPTERS
  • ARE MULTILAYERED MORPHOGENETIC SYSTEMS HIERARCHICAL?
  • LOOKING FORWARDS: WHAT REMAINS TO BE DONE?
  • Reference List
  • Index

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