Precision Medicine - Role of Autoantibodies in the Prediction and Care of Autoimmune Diseases

Report on the 14th Dresden Symposium on Autoantibodies, September 10-13, 2019
 
 
Pabst Science Publishers
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  • erschienen im Februar 2020
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  • 443 Seiten
 
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Precision Medicine - Role of Autoantibodies in the Prediction and Care of Autoimmune Diseases
Report on the 14th Dresden Symposium on Autoantibodies, September 10-13, 2019

AUTOANTIGENS, AUTOANTIBODIES, AUTOIMMUNITY
Volume 12 - 2019
Chapter 1
Autoantibodies and other Biomarkers in Precision Medicine

1 Kaleidoscope of autoimmunity - an update
Justyna Roszkiewicz, Yehuda Shoenfeld

2 Understanding and Addressing Gaps in Autoantibody Testing: Pragmatic Approaches to Precision Health
Marvin J. Fritzler

3 Autoantibodies in the management of individual patients with connective tissue disease - a Rheumatologist's perspective
Martin Aringer

4 GUT-joint axis: are rheumatologic processes initiated by enteric events?
Aaron Lerner, Patricia Wusterhausen, Sandra Neidhöfer, Torsten Matthias

5 Anti-DFS autoantibodies as probes to characterize the DFS70/LEDGFp75 interactome
Greisha L. Ortiz-Hernandez, Evelyn Sanchez-Hernandez, Shannalee R. Martinez, Michael Mahler, Carlos A. Casiano

6 Serum antibody profiling reveals a stratification of healthy toddlers into low, intermediate and high IgG responders towards autoantigens, infectious agents, and vaccine antigens
Quan-Zhen Li, Mei Yan, Patricia Pichilingue-Reto, Prithvi Raj, Igor Dozmorov, Edward K. Wakeland, Nicolai S.C. van Oers

7 Splice site mutation of FOXP3 gene in IPEX syndrome
Beáta Tóth

8 Immunomics profiling of patients with systemic autoinflammatory diseases using protein microarrays
Julie Krainer, Sandra Siebenhandl, Silvia Schönthaler, Sandra Nagy, Stephan Pabinger, Seza Özen, Dirk Foell, Marco Gattorno, Andreas Weinhäusel

9 Update on the DFS70 autoantibody/autoantigen system and current challenges in understanding its clinical and biological significance
Greisha L. Ortiz-Hernandez, Evelyn S. Sanchez-Hernandez, and Carlos A. Casiano

10 Novel anti-Thomsen-Friedenreich antigen-based immunoassay adds value to diagnosis and prognosis of Prostate cancer
Franziska Werner, Felix Hart, Jens Schmidt

11 Protein array screening identifies biomarkers for differential and predictive diagnostics
Karen Münzner, Franziska Werner

12 Identification of tumor autoantibody biomarker candidates for colon cancer by using high density peptide microarrays
Regina Soldo, Peter Hettegger, Andrea Stadler, Markus Degeorgi, Stefan Stiller, Walter Pulverer, Stefanie Brezina, Gernot Leeb, Andrea Gsur, Andreas Weinhäusel

13 Identification of nine unknown nuclear antigens as autoantibody targets in systemic autoimmune diseases
Zitao Zeng, Ramona Miske, Madeleine Scharf, Yvonne Denno, Christian Probst, Winfried Stöcker, Lars Komorowski

14 Autoantibodies in lung cancer patients treated with immune checkpoint inhibitors
Takanobu Jotatsu, Keishi Oda, Kazuhiro Yatera, Tomoko Hasegawa, Shin Tanaka, and Minoru Satoh


Chapter 2
Precision Medicine in the Care of Rheumatoid Arthritis and Ankylosing Spondylitis

15 Prevention of Rheumatoid Arthritis by early identification enabled through autoantibodies
Kevin Deane

16 Association of autoantibody profiles in Rheumatoid Arthritis with clinical phenotypes and outcome
Rene E. M. Toes

17 Novel strategies for improving serodiagnostics of rheumatoid arthritis
Daniela Sieghart, Paul Studenic, Günter Steiner

18 Addressing the diagnostic gap in rheumatoid arthritis by complementing the serology with genetic information
Isabel Gehring, Daniela Sieghart, Leonid Padyukov, Yutao Fu, Sascha Swiniarski, Josef Smolen, Maryam Poorafshar, Günter Steiner, Lars Klareskog

19 Glycosylation of antibodies in autoimmune diseases - Special focus on Fab glycans
Rene E. M. Toes

20 Value of anti-PAD autoantibodies for identifying informative clinical subsets in rheumatoid arthritis
Erika Darrah

21 Antibodies to protein-arginine deiminases as tools for diagnosis and patient stratification in rheumatoid arthritis
Laura Martinez-Prat, Victor Martinez-Taboada, Barbara Tolusso, Elisa Gremese, Marcos Lopez-Hoyos, Michael Mahler

22 Anti-PAD4 antibodies can help close the seronegative gap in Rheumatoid Arthritis
Laura Martinez-Prat, Barbara Tolusso, Chelsea Bentow, Anna Laura Fedele, Clara Di Mario, Elisa Gremese, Michael Mahler

23 The role of RA33 isotypes in early rheumatoid arthritis diagnostics
Maresa Grundhuber, Daniela Sieghart, Günter Steiner, Josef Smolen, Thomas Bergman, Johan Askling, Maryam Poorafshar, Sascha Swiniarski

24 The importance of isotypes of RF and anti-CCP for rheumatoid arthritis diagnostics
Daniela Sieghart, Alexander Platzer, Paul Studenic, Farideh Alasti, Maresa Grundhuber, Helmuth Haslacher, Günter Steiner

25 Diagnostic performance of anti-cyclic citrullinated peptide (CCP) 2 and CCP3.1 assays in early rheumatoid arthritis
Daniela Sieghart, Christian Konrad, Sascha Swiniarski, Helmuth Haslacher, Daniel Aletaha, Günter Steiner

26 Diagnostic test accuracy of anti-CCP tests depending on the duration of the disease, study design, antigen type and commercial test used: A critical appraisal and comparison of meta-analysis published
Carmen Andalucia, Dragan Urosevic, Sigrid Sjölander, Maryam Poorafshar

27 Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands
Annemirthe van Zanten, Suzanne Arends, Caroline Roozendaal, Pieter C. Limburg, Fiona Maas, Leendert A. Trouw, René E.M. Toes, Tom W.J. Huizinga, Hendrika Bootsma, Elisabeth Brouwer
Will be presented on behalf of the authors by Annechien J.A. Lambeck

28 Autoantibodies as predictors of response to therapy in rheumatoid arthritis patients
Daniela Sieghart, Alexander Platzer, Farideh Alasti, Paul Studenic, Maresa Grundhuber, Sascha Swiniarski, Stephan Blüml, Helmuth Haslacher, Josef Smolen, Günter Steiner

29 Seroreversion of autoantibodies to UH-RA.21 peptide is associated with CDAI remission in rheumatoid arthritis patients of the CareRA cohort
Patrick Vandormael, Silke Loyens, Pieter Ruytinx, Liesbeth De Winter, Veerle Stouten, Piet Geusens, Patrick Verschueren, Veerle Somers

30 Porphyromonas Gingivalis Peptidylarginine Deiminase from RA patient citrullinates major RA-autoantigens biomarkers for Interstitial Lung Disease Arthritis
Madeleine Jenning, Bianka Marklein, Anders Jimmy Ytterberg, Roman A. Zubarev, Karen Münzner, Dirkjan van Schaardenburg, Lotte A. van de Stadt, Gerd-Rüdiger Burmester, Karl Skriner

31 Lamin A and isoform 2 of desmoplakin as novel targets of antibodies against the UH-RA.21 peptide
Silke Loyens, Pieter Ruytinx, Liesbeth De Winter, Piet Geusens, Jean-Paul Noben, Patrick Vandormael, Veerle Somers

32 Immunogenicity of TNFa inhibitors: a cross-sectional and a prospective real-life experience in rheumatoid arthritis patients
Pier Luigi Meroni, Caterina Bodio, Claudia Grossi, Andrea Becciolini, Antonio Marchesoni, Matteo Filippini, Paola Migliorini, Roberto Caporali, Raffaele Pellerito, Francesco Ciccia, Piercarlo Sarzi-Puttini, Federico Perosa, Giuseppe Paolazzi, Ivana Hollan, Francesca Pregnolato, Maria OriettaBorghi

33 Polymorphisms in ikzf1 gene predict the non response to tumor necrosis factor a-blocking agents in Rheumatoid Arthritis patients
Pier Luigi Meroni, Caterina Bodio, Claudia Grossi, Daniela Privitera, Elena Raschi, Andrea Becciolini, Antonio Marchesoni, Matteo Filippini, Carlo Selmi, Roberto Caporali, Raffaele Pellerito, Francesco Ciccia, Piercarlo Sarzi-Puttini, Francesca Pregnolato, Maria Orietta Borghi

34 Serum calprotectin in the diagnostic work-up of Rheumatoid Arthritis
Lieve Van Hoovels, Bert Vander Cruyssen, Laura Bogaert, Stefanie Van Den Bremt, Xavier Bossuyt

35 The frequency of occurrence and the most common patterns of antinuclear antibodies in patients with rheumatoid arthritis and ankylosing spondylitis during Infliximab treatment
Marharyta V. Volkava, Alena V. Kundzer, Dirk Roggenbuck, Mandy Sowa

36 Immunoglobulin G autoantibodies to three novel peptides in early axial spondyloarthritis in two independent cohorts
Dana Quaden, Patrick Vandormael, Pieter Ruytinx, Piet Geusens, Johan Vanhoof, Frank Vandenabeele, Kurt de Vlam, Veerle Somers

37 Screening for immunoglobulin A antibody reactivity in early axial spondyloarthritis identifies novel antigenic targets
Dana Quaden, Janriama Sirait, Patrick Vandormael, PieterRuytinx, Kristoff Corten, Johan Vanhoof, Piet Geusens, Veerle Somers


Chapter 3
Precision Medicine in the Care of Systemic Sclerosis

38 The clinical spectrum of systemic sclerosis
Carlo Chizzolini

39 Antinuclear antibodies in Systemic Sclerosis: an overview
Carolien Bonroy, Karin Melsens, Vanessa Smith

40 Autoantibody profile in a cohort of Systemic Sclerosis patients from a single centre: clinical and serological associations
Micaela Fredi, Ilaria Cavazzana, Marzia Garofalo, Nice Carabellese, Fabio Ferrari, Paolo Airò, Angela Tincani, Franco Franceschini

41 Evaluation and verification of autoantibody profiles in systemic sclerosis
Ruben L. Smeets, Renate van der Molen, Brigit Kersten, Hans Koenen, Wynand Alkema, Charlotte Kaffa, Frank van den Hoogen, Irma Joosten, Madelon Vonk

42 A bioinformatic analysis supports a role of human cytomegalovirus as a trigger of Systemic Sclerosis-specific autoantibodies
Athanasios Gkoutzourelas, M. Barmakoudi, Dimitrios P. Bogdanos

43 Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis
Corrado Campochiaro, Simon D. Lytton, Svetlana Nihtyanova, Dietmar Fuchs, Voon H. Ong, Cristopher P. Denton

44 Clinical associations of anti-U11/U12 (RNPC-3) autoantibodies in patients with systemic sclerosis
Carmen Pilar Simeón, Mary Ann Aure, Fabrece Roup, Chelsea Bentow, Janire Perurena, Maite Sanz, Alfredo Guillen, Ana Marín, Vicent Fonollosa, Eduardo Callejas, Michael Mahler

45 Comparison of immunodominant epitope recombinant RNPC-3 and RNPC-3 peptide as a target of autoantibodies in patients with systemic sclerosis
Michael Mahler, Chelsea Bentow, Fabrece Roup, Haiyan Hou, May Y. Choi, Marvin J. Fritzler

46 Primary biliary cholangitis-related serology in systemic sclerosis patients: a three-years follow up study
Lisa Florin, Kaat Rubben, Amber Vanhaecke, Katrien Devreese, Filip De Keyser, Vanessa Smith, Carolien Bonroy


Chapter 4
Precision Medicine in the Care of Idiopathic Inflammatory Myopathies

47 A new approach for classification of autoimmune myositis
Yves Allenbach

48 Anti-cN-1A (NT5C1A) autoantibodies in autoimmune and infectious diseases
Ger J.M. Pruijn and Eline A. Visser

49 Autoantibodies in myositis measured using a novel particle based multi-analyte technology
Michael Mahler

50 Autoantibody's profile and clinical correlations in a cohort of IIM from a single center
Micaela Fredi, Ilaria Cavazzana, Micol Frassi, Paolo Airò, Angela Ceribelli, Nice Carabellese, Marco Taglietti, Minoru Satoh, Angela Tincani, Franco Franceschini

51 Subcutaneous calcinosis in autoimmune inflammatory myopathies: update on autoantibodies as biomarkers
Carlos A. von Mühlen

52 Anti-NXP2 antibodies: clinical and serological associations in a multicentric Italian study
Micaela Fredi, Ilaria Cavazzana, Angela Ceribelli, Simone Barsotti, Maurozio Benucci, Lorenzo Cavagna, Ludovico De Stefano, Andrea Doria, Marco Fornaro, Federica Furini, Roberto Gerli, Mariagrazia Giudizi, Marcello Govoni, Anna Ghirardello, Luca Iaccarino, Fiorenzo Iannone, Maria Infantino, Alessandro Mathieu, Emiliano Marasco, Paola Migliorini, Boaz Palterer, Matteo Piga, Federico Pratesi, Antonella Radice, Valeria Ricceri, Carlo Selmi, Marilina Tampoia, Alessandra Tripoli, Giovanni Zanframundo, Angela Tincani, Franco Franceschini, on behalf of Forum Italiano per la Ricerca Malattie Autoimmuni (FIRMA)

53 Prevalence of anti-C5'N1A autoantibodies in a French cohort of patients with Inclusion Body Myositis
David Goncalves, Thierry Vincent, Laure Gallay, Nathalie Streichenberger, Raul Juntas- Morales, Sylvain Dubucquoi, Daniela Lakomy, Catherine Johanet, Françoise Fortenfant, René-Louis Humbel, Xavier Bossuyt, Pascale Chretien, Benoit Nespola, Sophie Hue, Frédéric Coutant, Nicole Fabien

54 Addition of cN-1A as a target for detection of autoantibodies associated with Inclusion Body Myositis to a multiparameter lineblot immunoassay for autoimmune inflammatory myopathies
Julia Janz, Anthonina Ott, Thomas Scheper, Wolfgang Schlumberger, Wolfgang Meyer

55 Profiling autoantibodies in Idiopathic Inflammatory Myopathies, Systemic Sclerosis and Systemic Lupus Erythematosus
Quan-Zhen Li, Mei Yan, Chengsong Zhu, Li Wang, Indu Raman, Edward Wakeland, Xiaoxia Zuo

56 Reactivity profile of novel human monoclonal antibodies to SAE, TIF1?, MDA5 and NXP2
Michaelin Richards, Andrea Seaman, Charles Warren, Adrian Saclolo, Carolina Auza, Kishore Malyavantham, Michael Mahler

57 Prevalence of anti-Ku antibodies in various connective tissue diseases measured by a novel particle based multi-analyte technology
Andrea Seaman, Marychel Tiongson, Charles Warren, Gabriella Morozzi, Maria Grazia Bacarelli, Danilo Villalta, Maria Orietta Borghi, Pier Luigi Meroni, Albert Selva O'Callaghan, Michael Mahler


Chapter 5
Precision Medicine in the Care of Antiphospholipid Syndrome and Systemic Vasculitides

58 Antiphospholipid antibodies in clinical practice
Cecilia Nalli

59 Profiling of criteria and non-criteria antiphospholipid antibodies in Russian patients with SLE
Olga Tkachenko, Sergey Lapin, Elizaveta Belolipetskaia, Irina Beliaeva, Valentina Myachikova, Alexey Maslyansky, Dirk Roggenbuck

60 Testing of anti-phosphatidylserine/prothrombin antibodies - Added value for APS
diagnostics?
Veronika Mikulová, Irena Francová, Helena Posová, Tomás Zima

61 Clinical performance of a novel Multi-Analyte Assay for the diagnosis of APS in a Spanish cohort
Estíbaliz Ruiz-Ortiz, Natalia Egri, Laura Rubio, Albert Pérez-Isidro, Andrea Seaman, Carlos Ramírez, Douglas Mackey, Ricard Cervera, Gerard Espinosa, Odette Viñas, Michael Mahler

62 Vasculitis biomarkers in the era of the personalized medicine
Elena Csernok


Chapter 6
Precision Medicine in the Care of Organ Specific Autoimmune Diseases

63 Update on IgG4-mediated autoimmune diseases
Inga Koneczny

64 Microbial transglutaminase is a potential driver of autoimmunity
Ajay Ramesh, Aaron Lerner, Sandra Neidhöfer, Patricia Wusterhausen, Torsten Matthias

65 Probiotics: If it does not help it does not do any harm in celiac disease. Really?
Aaron Lerner, Yehuda Shoenfeld, Torsten Matthias

66 Autoantibody profiling in Celiac Disease: The value beyond IgA anti-tTG
Xavier Bossuyt

67 CHI3L1 in IBD - A potential association with ASCA
Claudia Deutschmann, Dirk Roggenbuck, Peter Schierack

68 A location based prediction model in Crohn's disease regarding a novel serological marker, Chitinase 3-like 1 autoantibodies
Nora Sipeki, Patricia Kovats, Claudia Deutschmann, Peter Schierack, Dirk Roggenbuck, Maria Papp

69 Anti-GP2 autoantibodies are biomarkers of disease severity and prognosis in patients with primary sclerosing cholangitis (PSC)
Ewa Wunsch, Malgorzata Milkiewicz, Marcin Krawczyk, Marta Slimak-Mastrobuoni, Zakera Shums, Mary Ann Aure, Chelsea Bentow, Gary L. Norman, Dirk Roggenbuck, Piotr Milkiewicz

70 The significance of antibodies against Glycoprotein 2 in Chinese inflammatory bowel disease patients
Shulan Zhang

71 Monitoring of drug level and anti-drug antibody production during vedolizumab therapy in patients with inflammatory bowel disease
Gábor Nagy, Éva Török, Károly Palatka, Zsófia. Kébel, Péter Antal-Szalmás

72 Pre-analytical evaluation of circulating calprotectin in serum and citrate plasma from healthy donors
Jenna Memmolo, Roger Albesa, Emily FitzGerald, Maria Infantino, Mariangela Manfredi, Valentina Grossi, Maurizio Benucci, Francesca Li Gobbi, Alessandra Matucci, Filippo Sarra, Michael Mahler

73 Gastric parietal cell and intrinsic factor autoantibodies in children and young adults with type 1 diabetes
Raivo Uibo, Aleksandr Peet, Kaire Heilman, Kaja Metsküla

74 Autoantibodies associated with Bronchiolitis Obliterans of chronic allograft dysfunction in lung transplantation
Quan-Zhen Li, Chengsong Zhu, Mei Yan, Leying Feng, Lance Terada, Vaidehi Kaza

75 The impact of prophylactic treatment of recombinant banana lectin on the innate immune response in TNBS induced colitis in C57BL/6 mice
Radmila Miljkovic, Emilija Marinkovic, Ana Filipovic, Ivana Lukic, Mina Popovic, Zorana Lopandic, Marija Gavrovic-Jankulovic, Marijana Stojanovic

76 Evaluation of maternal infertility related autoantibody test results in a three-year period
Zsuzsanna Csizmadia, Katalin Böröcz, Vivien Varga, Noémi Balázs, Timea Berki


Chapter 7
Precision Medicine in the Care of Heart Diseases

77 Autoimmune Cardiac Channelopathies
Mohamed Boutjdir

78 Prognostic significance of low anti-beta1 adrenergic receptor antibody concentrations in acute coronary syndrome
Diana Ernst, Johan Westerbergh, Georgios Sogkas, Alexandra Jablonka, Gerrit Ahrenstorf, Reinhold Ernst Schmidt, Harald Heidecke, Lars Wallentin, Torsten Witte, Gabriela Riemekasten

79 Chronic fatigue syndrome, postural orthostatic tachycardia and human papillomavirus vaccine: the common denominator - anti-neurotransmitter receptor autoantibodies
Varvara A. Ryabkova, Darja Kanduc, Leonid P. Churilov, Yehuda Shoenfeld

80 BC 007 neutralizes functional autoantibodies against G protein-coupled receptors: Results of the Phase 1 clinical trial proof successful mode of action
Niels-Peter Becker, Johannes Müller, Annekathrin Haberland, Gerd Wallukat, Katrin Wenzel, Peter Göttel, Sarah Schulze-Rothe, Ingolf Schimke, Tuba Yilmaz, Ayse Abay, Anne Wallukat, Anne-Sophie Hönicke, Susanne Becker


Chapter 8
Precision Medicine in the Care of Neurologic Autoimmune Diseases

81 Holistic characterization of the repertoire of targeted autoantigens of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Christian P. Moritz, Oda Stoevesandt, Yannick Tholance, Carole Rosier, Karine Ferraud, Jean-Philippe Camdessanché, Jean-Christophe Antoine

82 Neurochondrin neurological autoimmunity
Shahar Shelly, Thomas J. Kryzer, Vanda A. Lennon, Lars Komorowski, Ramona Miske, Winfried Stöcker, Mark D. Anderson, Shannon R. Hinson, Sean J. Pittock, Andrew McKeon

83 Incidence of antibodies against the node of Ranvier in a prospective cohort of 1000 CIDP
José Boucraut, Émilien Delmont, Alexandre Brodovitch, Shahram Attarian and the French CIDP group

84 Value of anti-HNK1 antibodies in anti-MAG neuropathies: an analysis of 144 sera
José Boucraut, Alexandre Brodovitch, Jean Claude Antoine, Stéphane Paul, Shahram Attarian, Émilien Delmont

85 The importance of second level confirmatory IHC assay to confirm autoantibody CSF
expression in a case of Morvan syndrome
Martina Fabris, Greta Macorig, Romina Milanic, Laura Cecotti, Maria Rachele Bianchi, Piera De Gaspari, Francesco Curcio, Michele Rana

86 Identification of DAGLA as an autoantibody target in cerebellar or hippocampal degeneration
Ramona Miske, Madeleine Scharf, Stefanie Hahn, Yvonne Denno, Farid Benkhadra, Nadine Rochow, Christian Probst, Bianca Teegen, Winfried Stöcker, Lars Komorowski

87 Identification of RGS8 as an autoantibody target in paraneoplastic cerebellar syndrome
Ramona Miske, Madeleine Scharf, Christian Borchers, Yvonne Denno, Bianca Teegen, Nadine Rochow, Christian Probst, Winfried Stöcker, Pawel Kermer, Lars Komorowski

88 Epitope mapping for anti-FGFR3 autoantibodies in Sensory Neuropathy
Christian P. Moritz, Lauriane Mohr, Yannick Tholance, Martin Jung, Evelyne Reynaud- Federspiel, Karine Ferraud, Jean-Philippe Camdessanché, Jean-Christophe Antoine

89 Autoimmune gait disturbance accompanying adaptor protein-3B2-IgG
Josephe A. Honorat, A. Sebastian Lopez-Chiriboga, Thomas J. Kryzer, Vanda A. Lennon, Lars Komorowski, Madeleine Scharf, Winfried Stöcker, Shannon R. Hinson, Sean J. Pittock, Christopher J. Klein, Andrew McKeon

90 Identification of novel maternal autoantibodies for autism spectrum disorder using cDNA phage display
Rut Mazón-Cabrera, Patrick Vandormael and Veerle Somers


Chapter 9
Methodical Aspects of Autoantibody Detection

91 Standardisation and harmonisation of quantitative autoantibody testing
Joanna Sheldon

92 Establishment of international autoantibody reference standards for the detection of anti-NuMA, anti-multiple nuclear dots, and anti-GW body autoantibodies
Bing Zheng, Rodrigo A. Mora, Marvin J. Fritzler, Minoru Satoh, Ignacio Garcia-De La Torre, Katherine Boylan, Kathryn Kohl, Luis E.C. Andrade, Edward K.L. Chan

93 Development and clinical use of a technique to quantify autoantibodies in immune
complexes
Johan Rönnelid and Azita Sohrabian

94 Simultaneous detection and quantification of DNA- and protein biomarkers in a microfluidic microbead chip
Stefan Rödiger, Franziska Dinter, Michal Burdukiewicz, Peter Schierack, Werner Lehmann, Joerg Nestler, Gregory Dame

95 Single testing vs. double testing strategy in the screening of connective tissue disease:
A comparison of clinical performance and reimbursement in Germany
Carmen Andalucia, Martin Brandenburg and Sigrid Sjölander

96 Comparison of commonly used dsDNA assay types in order to better support an accurate clinical diagnosis
Katalin Böröcz, Zsuzsanna Csizmadia, Vivien Varga, Timea Berki

97 Clinical comparison of Aptiva with QUANTA Flash for the detection of anti-dsDNA autoantibodies
Charles Warren, Andrea Seaman, Michelle Anne Amio, Chelsea Bentow, Gabriella Morozzi, Maria Grazia Bacarelli, Danilo Villalta, John Hanly, Michael Mahler

98 What's behind the pattern? A new method to detect anti-DFS70 autoantibodies
Jean-Luc Charuel, Hanna Berkner, Pascale Ghillani-Dalbin, Makoto Miyara and Lucile Musset

99 A novel indirect immunofluorescent method for anti-DFS7O antibodies
Pelin Onarer, Esvet Mutlu, Gözde Öngüt, Meral Gültekin

100 Prospective validation of a novel DFS70 immunoassay in samples with suspected ANA-associated autoimmune rheumatic diseases
Olaf Nickel, Stephan Borte, Andreas Pöge, Michael Borte, Martin Brandenburg, Raik Wolf, Johannes Wolf

101 EliA DFS70 and other routine methods for detection of anti-DFS70 antibodies
Werner Klotz, Manfred Herold

102 Verification of the new chemiluminescent immunoassay for DFS protein 70 antibodies (anti-DFS70)
Lovorka Derek, Andrea Tesija Kuna, Milena Njegovan, Ines Vukasovic

103 Clinical evaluation of a particle-based multi-analyte technology for the detection of anti-Th/To autoantibodies using Th/To subunits Rpp25 and Rpp38
Michael Mahler, Karl Norvell, Andrea Seaman, Marychel Tiongson, Charles Warren, Chelsea Bentow, Lorenzo Beretta

104 Evaluation of two distinct assays for detection of anti-Th/To antibodies in systemic sclerosis: a cross-sectional study
Janire Perurena-Prieto, Andrea Seaman, Karl Norvell, Chelsea Bentow, Eduardo Luis Callejas-Moraga, Alfredo Guillén-Del-Castillo, Laura Viñas-Gimenez, Ana Marín-Sánchez, Eva Balada-Prades, Vicent Fonollosa-Plá, Maria Sanz-Martinez, Carmen Pilar Simeón- Aznar

105 Anti-PL-7 is the most frequent t-RNA-synthetase antibody in routine laboratory testing
Michael L. Grünwald, Kai Pitterle

106 Evaluation of a novel bead based assay for the detection of HMGCR autoantibodies in
Idiopathic Inflammatory Myopathies
Michaelin Richards, Charles Warren, Andrea Seaman, Anna Ghirardello, Andrea Doria, Albert Selva O'Callaghan, Franco Fanceschini, Sophie Hue, Marvin J. Fritzler, Michael Mahler

107 Increased sensitivity for PR3-ANCA using a novel chemiluminescence immunoassay
Elion Hoxha, Rolf A.K. Stahl, Silke R. Brix, Torsten Witte, Florian Seebeck, Wolfgang Schlumberger, Cornelia Daehnrich

108 Comparison study of four different methods for proteinase 3 and myeloperoxidase antibody detection
Katarina Gugo, Gordana Juricic, Vedrana Drvar

109 Novel ELISA to aid the diagnosis of autoimmune gastritis
Alexander Kühnl, Sandra Saschenbrecker, Lars Komorowski, Christian Probst, Giampaola Pesce, Wolfgang Schlumberger, Cornelia Dähnrich

110 Evaluation of a novel chemiluminescent immunoassay for the detection of anti-intrinsic factor autoantibodies
A. Llanes, Roger Albesa, Emily Fitzgerald, Michael Mahler

111 Multiparameter assay for the detection of IgA antibodies in autoimmune gastrointestinal diseases
Julia Janz, Anthonina Ott, Thomas Scheper, Wolfgang Schlumberger, Wolfgang Meyer

112 Multiparameter assay for the detection of IgG antibodies in autoimmune gastrointestinal diseases
Julia Janz, Anthonina Ott, Thomas Scheper, Wolfgang Schlumberger, Wolfgang Meyer

113 Diagnostic performance of indirect immunofluorescence microscopy and enzyme-linked immunosorbent assays in bullous pemphigoid, pemphigus vulgaris and pemphigus foliaceus
Pieter De Kesel, Sofie De Schepper, Carolien Bonroy

114 A newly developed chemiluminescence immunoassay improves the detection of anti-PLA2R autoantibodies in primary membranous nephropathy
Alexander Kühnl, Cornelia Dähnrich, Sandra Saschenbrecker, Iva Gunnarsson, Pierre Ronco, Hanna Debiec, Wolfgang Schlumberger

115 Development of the first 1-step radioactive immunoassay for the detection of TRAb
Johannes Roggenbuck

116 Evaluation and comparison of the analytical performance of autoimmune antibodies on the HOB BioCLIA® 1200 Automated Immunoassay Analyzer to the Phadia 250® System
Christine Knies, Michael Olivo, Ralf Tönnies, Philipp von Landenberg

117 Evaluation and comparison of the analytical performance of autoimmune antibodies on the HOB BioCLIA® 6500 automated immunoassay analyzer to the Phadia 250® system
Christine Knies, Michael Olivo, Ralf Tönnies, Philipp von Landenberg


Chapter 10
Update on Antinuclear Antibody (ANA) Screening and Pattern Differentiation

118 2019 - ANA detection: real life and EULAR recommendations
Pier Luigi Meroni, Maria Orietta Borghi

119 The behavior of pattern and titer of HEp-2 IFA in lupus patients according to disease activity status
Mônica Simon Prado, Alessandra Dellavance, Silvia Helena Rodrigues, Luis Eduardo Coelho Andrade

120 A survey on methodological aspects of anti-nuclear antibody testing
Martine Vercammen, Sylvia Broeders, Carolien Bonroy, Wim Coucke, Laurence Lutteri, Sofie Schouwers, Lieve Van Hoovels, Xavier Bossuyt

121 Consensus on ANA patterns (ICAP): from clinical association towards clinical relevance of HEp-2 indirect immunofluorescence patterns
Jan Damoiseaux

122 A new diagnostic algorithm for pattern-oriented autoantibody testing according to the ICAP nomenclature: a pilot study
Maria Infantino, Teresa Carbone, Mariangela Manfredi, Valentina Grossi, Antonio Antico, Maria Piera Panozzo, Ignazio Brusca, Maria Grazia Alessio, Giulia Previtali, Stefan Platzgummer, Luigi Cinquanta, Giusy Paura, Gaia Deleonardi, Maria Teresa Trevisan, Antonella Radice, Caterina Castiglione, Tiziana Imbastaro, Martina Fabris, Giampaola Pesce, Brunetta Porcelli, Lucia Terzuoli, Maria Concetta Sorrentino, Marilina Tampoia, Danilo Villalta, Maria Elisabetta Conte, Giuseppina Barberio, Nicoletta Gallo, Maurizio Benucci, Nicola Bizzaro

123 ICAP's recommendations to describe patterns observed on HEp-2 cells are broadly accepted in Austria
Manfred Herold, Werner Klotz

124 ANA nomenclature and detection strategies (IIFT vs. collagenosis screen): experiences from proficiency testing and questionnaires (EASI)
Martin Blüthner

125 AC-XX: beyond ICAP's 29 patterns
Manfred Herold

126 Dissecting pleomorphic patterns: PCNA, SG2NA (AC-30) and Pseudo-PCNA patterns
Werner Klotz, Manfred Herold

127 Evaluation of anti-nuclear antibody test utilization patterns in Alberta
Alex C. Chin, Jeannine Viczko, Jan Willem Cohen Tervaert, Anthony Russell, Robert Ferrari, Joshua E. Raizman, Barry Kyle, Ann E. Clarke, Marvin J. Fritzler, Connie Prosser

128 ANA (HEp-2) cytoplasmic IF-patterns AC-19 and AC-20 and myositis specific antibodies results
Michael L. Grünwald, Irene Kolbe, Christina Kamp, Wolfgang Meyer

129 Immunofluorescence patterns on HEp-2 cells not included in ICAP's classification tree
Werner Klotz, Manfred Herold

130 Multi-center study for the association of anti-p80/coilin with anti-DFS70 in ANA positive patients
Michael Mahler, Chelsea Bentow, Mary Ann Aure, Fabrece Roup, Amanda Jiao, Luis E.C. Andrade, Maria Infantino, Vincent Ricchiuti, Joe Adams, May Y. Choi, Meifeng Zhang, Marvin J. Fritzler

131 Artificial intelligence for automated pattern recognition
Rico Hiemann, Alexander Hiemann, Jonas Noack, Dirk Roggenbuck, Karsten Conrad, Peter Schierack

132 Feasibility of ANA IFA harmonization: analytical evaluation of candidate standards on four commercially available automated ANA IFA analyzers
Lieve Van Hoovel, Edward Chan, Luis Andrade, Kai Fechner, Daria Franceschi, Kishore Malyavantham, Bernd Stoeckl, Xavier Bossuyt

133 The clinical performance of HEp-2 IIFA on the fully automated IFx 360 System
Shuxia Zhou, Jeri Seiki, John Breneman

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