This book focuses on diverse aspects of the relationship between hypertension and brain damage, providing up-to-date information that will be of interest to both clinicians and researchers. After an introductory chapter on epidemiology, the significance of various comorbidities that represent risk factors for brain damage in the context of hypertension is discussed. Detailed consideration is then given to the effects of hypertension on small and large cerebral arteries and the consequences for brain damage. Similarly, the association between hypertension and ischemic and hemorrhagic stroke is fully explored, and the evidence and guidelines regarding reduction of high blood pressure during the acute phase of each form of stroke are summarized. Both the primary and the secondary prevention of stroke are addressed, with presentation of the results of key trials. Readers will also find interesting new perspectives on the roles of different imaging techniques, including CT and functional MRI, in detecting and diagnosing brain damage in patients with hypertension. The closing chapters review the relation of hypertension to subjective and objective cognitive failures and to cognitive decline and dementia.
Antonio Coca is Professor of Internal Medicine at the University of Barcelona, Spain, and Head of the Hypertension & Vascular Risk Unit at the Hospital Clìnic in Barcelona. He is Chair of Working Group on "Hypertension and the Brain" of the European Society of Hypertension, and Chair of the "Council on Hypertension" of the European Society of Cardiology, working group.
Chapter 1. Epidemiology of hypertension and brain disease.- Chapter 2. Comorbidities often associated to brain damage in hypertension: Dyslipidemia.- Chapter 3. Comorbidities often associated to brain damage in hypertension: Smoking habits and alcohol intake.- Chapter 4. Comorbidities often associated to brain damage in hypertension: CAD, CKD and SAOS.- Chapter 5. Pathophysiology of brain damage in hypertension: small vessel disease.- Chapter 6. Pathophysiology of brain damage in hypertension: large artery disease.- Chapter 7. Hypertension and ischemic stroke.- Chapter 8. Hypertension and hemorrhagic stroke.- Chapter 9. Imaging techniques for detection and diagnosis of brain damage.- Chapter 10. Primary prevention of stroke.- Chapter 11. Management of high blood pressure in acute ischemic stroke.- Chapter 12. Management of high blood pressure in acute hemorrhagic stroke.- Chapter 13. Secondary prevention of stroke.- Chapter 14. Hypertension and subjective cognitive failures.- Chapter 15. Hypertension, cognitive decline and dementia.