Gynecologic Pathology, An Issue of Surgical Pathology Clinics, E-Book

 
 
Elsevier (Verlag)
  • 1. Auflage
  • |
  • erschienen am 11. Juni 2016
  • |
  • 100 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
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978-0-323-44639-6 (ISBN)
 

This issue of the Surgical Pathology Clinics, edited by Drs. Blaise Clarke and Glenn McCluggage, focuses on Gynecologic Pathology. Topics covered in the issue include, but are not limited to: Gynecologic manifestations of the DICER1 syndrome; Prophylactic gynecologic specimens from hereditary cancer carriers; Lynch syndrome associated endometrial cancer; Peutz-jeghers syndrome associated gynecologic tumors; Gynecologic manifestations of less commonly encountered hereditary syndromes; and Clinical testing for hereditary predisposition.

  • Englisch
  • Philadelphia
  • |
  • USA
Elsevier Health Sciences
  • 12,31 MB
978-0-323-44639-6 (9780323446396)
0323446396 (0323446396)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Gynecologic Pathology
  • Copyright
  • Contributors
  • CONSULTING EDITOR
  • EDITORS
  • AUTHORS
  • Contents
  • Preface: Gynecologic Pathology
  • Ovarian Cancer in Hereditary Cancer Susceptibility Syndromes
  • Lynch Syndrome: Female Genital Tract Cancer Diagnosis and Screening
  • Small-Cell Carcinoma of the Ovary of Hypercalcemic Type (Malignant Rhabdoid Tumor of the Ovary): A Review with Recent Devel ...
  • Gynecologic Manifestations of the DICER1 Syndrome
  • Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathol ...
  • Gynecologic Manifestations of Less Commonly Encountered Hereditary Syndromes
  • Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma
  • Testing for Hereditary Predisposition in Patients with Gynecologic Cancers, Quo Vadis?
  • Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers
  • Special Article
  • Image Analysis in Surgical Pathology
  • SURGICAL PATHOLOGY CLINICS
  • FORTHCOMING ISSUES
  • September 2016
  • December 2016
  • March 2017
  • RECENT ISSUES
  • March 2016
  • December 2015
  • September 2015
  • Preface: Gynecologic Pathology
  • Ovarian Cancer in Hereditary Cancer Susceptibility Syndromes
  • ABSTRACT
  • OVERVIEW
  • OVARIAN CARCINOMA
  • HIGH-GRADE SEROUS CARCINOMA
  • LOW-GRADE SEROUS CARCINOMA
  • CLEAR CELL CARCINOMA
  • ENDOMETRIOID CARCINOMA
  • MUCINOUS CARCINOMA
  • OVARIAN CARCINOMA: HISTOTYPE DIFFERENTIAL DIAGNOSIS
  • HEREDITARY BREAST AND OVARIAN CANCER SYNDROME
  • LYNCH SYNDROME (HEREDITARY NONPOLYPOSIS COLORECTAL CANCER SYNDROME)
  • SUMMARY
  • REFERENCES
  • Lynch Syndrome
  • ABSTRACT
  • OVERVIEW
  • FUNCTION OF DNA MISMATCH REPAIR GENES
  • LYNCH SYNDROME FEMALE GENITAL TRACT TUMORS
  • LYNCH SYNDROME FEMALE GENITAL TRACT CANCER RISK DIFFERS BY MUTATIONAL STATUS
  • SCREENING FOR LYNCH SYNDROME
  • TESTING FOR LYNCH SYNDROME
  • GERMLINE MUTATIONAL ANALYSIS
  • IMMUNOHISTOCHEMISTRY FOR DNA MISMATCH REPAIR PROTEINS
  • MICROSATELLITE INSTABILITY ANALYSIS
  • MLH1 PROMOTER METHYLATION ASSAY
  • DNA MISMATCH REPAIR GENE MUTATION ANALYSIS
  • SOMATIC MUTATIONAL ANALYSIS
  • PROGNOSTIC AND THERAPEUTIC IMPLICATIONS OF MISMATCH REPAIR ABNORMALITIES IN ENDOMETRIAL AND OVARIAN CARCINOMA
  • SURVEILLANCE AND RISK-REDUCING STRATEGIES FOR ENDOMETRIAL AND OVARIAN CARCINOMAS IN LYNCH SYNDROME
  • SUMMARY
  • REFERENCES
  • Small-Cell Carcinoma of the Ovary of Hypercalcemic Type (Malignant Rhabdoid Tumor of the Ovary)
  • ABSTRACT
  • OVERVIEW AND HISTORY OF THE DISEASE
  • CLINICAL PRESENTATION AND OUTCOME
  • PATHOLOGY OF SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE
  • GENETICS AND HISTOGENESIS OF SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE
  • USING IMMUNOHISTOCHEMISTRY TO DIAGNOSE SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE
  • MANAGEMENT OF SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE
  • CURRENT AND FUTURE RESEARCH
  • DIAGNOSTIC/GENETIC TESTING ALGORITHM FOR SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE
  • DIFFERENTIAL DIAGNOSIS OF SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE
  • SEX CORD-STROMAL TUMORS
  • OVARIAN SMALL-CELL CARCINOMA OF PULMONARY TYPE (SMALL-CELL NEUROENDOCRINE CARCINOMA)
  • DESMOPLASTIC SMALL ROUND CELL TUMOR
  • EWING FAMILY OF TUMORS
  • MISCELLANEOUS NEOPLASMS
  • REFERENCES
  • Gynecologic Manifestations of the DICER1 Syndrome
  • ABSTRACT
  • MOLECULAR OVERVIEW OF DICER1
  • OVARIAN SEX CORD-STROMAL TUMORS
  • BACKGROUND AND CLINICAL FEATURES
  • HISTOLOGIC FEATURES
  • DIFFERENTIAL DIAGNOSIS
  • PROGNOSIS
  • CERVICAL EMBRYONAL RHABDOMYOSARCOMA
  • BACKGROUND AND CLINICAL FEATURES
  • HISTOLOGIC FEATURES
  • DIFFERENTIAL DIAGNOSIS
  • PROGNOSIS
  • OTHER OVARIAN NEOPLASMS POSSIBLY LINKED TO DICER1 SYNDROME
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Peutz-Jeghers Syndrome
  • ABSTRACT
  • OVERVIEW
  • INTRODUCTION
  • HISTORY OF THE DISEASE
  • CLINICAL FEATURES
  • PATHOBIOLOGICAL UNDERPINNINGS
  • GYNECOLOGIC TUMORS IN PEUTZ-JEGHERS SYNDROME
  • SEX CORD TUMOR WITH ANNULAR TUBULES
  • Brief Introduction
  • Gross Features
  • Microscopic Features
  • Differential Diagnosis
  • Diagnosis
  • Prognosis
  • OVARIAN SERTOLI CELL TUMOR
  • Brief Introduction
  • Gross Features
  • Microscopic Features
  • Differential Diagnosis
  • Diagnosis
  • Prognosis
  • GASTRIC-TYPE ENDOCERVICAL ADENOCARCINOMA
  • Brief Introduction
  • Gross Features
  • Microscopic Features
  • Differential Diagnosis
  • Diagnosis
  • Prognosis
  • EXTREMELY WELL-DIFFERENTIATED GASTRIC-TYPE ADENOCARCINOMA AND LOBULAR ENDOCERVICAL GLANDULAR HYPERPLASIA
  • Brief Introduction
  • Gross Features
  • Microscopic Features
  • Differential Diagnosis
  • Diagnosis
  • Prognosis
  • RECOMMENDATIONS FOR SCREENING, MANAGEMENT, AND ADDITIONAL GENETIC TESTING
  • REFERENCES
  • Gynecologic Manifestations of Less Commonly Encountered Hereditary Syndromes
  • ABSTRACT
  • HEREDITARY LEIOMYOMATOSIS RENAL CELL CARCINOMA SYNDROME
  • CLINICAL FEATURES
  • GROSS/MICROSCOPIC FEATURES AND DIAGNOSIS
  • DIFFERENTIAL DIAGNOSIS
  • PROGNOSIS
  • TUBEROUS SCLEROSIS COMPLEX
  • LYMPHANGIOLEIOMYOMATOSIS
  • PERIVASCULAR EPITHELIOID CELL TUMOR
  • DIFFERENTIAL DIAGNOSIS
  • PROGNOSIS
  • COWDEN SYNDROME
  • CLINICAL FEATURES
  • PTEN AND ENDOMETRIAL CANCER
  • PROGNOSIS
  • NEVOID BASAL CELL CARCINOMA SYNDROME
  • CLINICAL FEATURES
  • GROSS/MICROSCOPIC FEATURES AND DIAGNOSIS
  • DIFFERENTIAL DIAGNOSIS
  • PROGNOSIS
  • VON HIPPEL-LINDAU SYNDROME
  • CLINICAL FEATURES
  • GROSS/MICROSCOPIC FEATURES AND DIAGNOSIS
  • DIFFERENTIAL DIAGNOSIS
  • PROGNOSIS
  • MAFFUCCI SYNDROME AND OLLIER DISEASE
  • CLINICAL FEATURES
  • GROSS/MICROSCOPIC FEATURES AND DIAGNOSIS
  • DIFFERENTIAL DIAGNOSIS
  • PROGNOSIS
  • CARNEY COMPLEX
  • OVARIAN LESIONS IN CARNEY COMPLEX
  • DIFFERENTIAL DIAGNOSIS
  • PROGNOSIS
  • REFERENCES
  • Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma
  • ABSTRACT
  • LYNCH SYNDROME
  • TUMOR TESTING AND PITFALLS IN TEST INTERPRETATION
  • Immunohistochemistry
  • Microsatellite Instability and MLH1 Methylation Analyses
  • DISCREPANCIES BETWEEN TISSUE TESTING AND GENETIC TESTING
  • Known Mismatch Repair Gene Mutations and Ambiguous or Normal Tissue Testing Results
  • Abnormal Tissue Testing Results and No Detectable Mismatch Repair Gene Mutations
  • STRATEGIES AND CHALLENGES OF SCREENING FOR LYNCH SYNDROME IN ENDOMETRIAL CARCINOMA
  • PATHOLOGIC FEATURES OF LYNCH SYNDROME-ASSOCIATED ENDOMETRIAL CANCER
  • REFERENCES
  • Testing for Hereditary Predisposition in Patients with Gynecologic Cancers, Quo Vadis?
  • ABSTRACT
  • OVERVIEW
  • GENETIC TESTING
  • HISTORIC METHODS
  • CURRENT TESTING METHODS
  • WHEN IS A GENE READY FOR ROUTINE CANCER PREDISPOSITION TESTING?
  • SINGLE-GENE VERSUS GENE PANEL VERSUS WHOLE-EXOME VERSUS WHOLE-GENOME APPROACHES TO CLINICAL GENETIC TESTING
  • SOMATIC GENETIC TESTING OR GERMLINE GENETIC TESTING?
  • OPTIMIZING ACCESS TO GENETIC TESTING FOR HEREDITARY PREDISPOSITION TO GYNECOLOGIC CANCERS
  • REFERENCES
  • Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers
  • ABSTRACT
  • OVERVIEW
  • MUTATIONS OF BRCA1 AND BRCA2 AND PREVENTION OF HIGH-GRADE SEROUS CARCINOMA
  • PROCESSING OF RISK-REDUCING SALPINGO-OOPHORECTOMY SPECIMENS
  • GROSS FEATURES
  • OCCULT HIGH-GRADE SEROUS CARCINOMA
  • MICROSCOPIC
  • SEROUS TUBAL INTRAEPITHELIAL CARCINOMA
  • MICROSCOPIC
  • SEROUS TUBAL INTRAEPITHELIAL LESION
  • MICROSCOPIC
  • P53 SIGNATURE
  • MICROSCOPIC
  • DIFFERENTIAL DIAGNOSIS
  • LYNCH SYNDROME
  • REFERENCES
  • Image Analysis in Surgical Pathology
  • ABSTRACT
  • OVERVIEW
  • PROCESSES
  • IMAGE SEGMENTATION
  • Splitting
  • Thresholding, Watershedding, and/or Histogram-Based Techniques
  • Clustering
  • Edge Detection
  • Partial-Differential Equations
  • Graph Partitioning
  • Trainable Techniques
  • STATISTICAL CLASSIFICATION
  • Markov Chains and Markov Meshes
  • Naive Bayes Classifiers
  • Support Vector Machines
  • Regression
  • Random Forest Classifiers
  • FEATURE EXTRACTION, RESULT GENERATION, INTERPRETATION, AND REPORTING
  • IMAGE ANALYSIS FOR BASIC AND TRANSLATIONAL RESEARCH USE
  • IMAGE ANALYSIS FOR CLINICAL USE
  • SUMMARY
  • REFERENCES

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