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Chalcones: From Drug Discovery to Pharmaceutical Applications serves as a comprehensive reference on chalcones, detailing their natural occurrence, synthetic methods, and therapeutic applications. The book provides both novice and experienced researchers with the foundational knowledge necessary to advance their work in this area. Sections cover the natural sources of chalcones, various extraction methods, structural characterization techniques, synthesis, and their role in organic chemistry and metal complexes, while also addressing pharmacokinetic properties, toxicity, and the medicinal uses of chalcones, including their effectiveness against viruses, bacteria, cancer, and neurodegenerative diseases. Final sections explore chalcone-containing products, drug formulation strategies, and clinical trials involving chalcone-based drug candidates. This reference is an essential resource for pharmaceutical researchers, providing critical insights into the applications and potential of chalcones in drug development and therapeutic interventions.
- Offers comprehensive coverage of chalcone synthesis and characterization techniques for effective research applications
- Provides in-depth analysis of pharmacokinetics and toxicity to guide safe drug development
- Offers a detailed exploration of therapeutic uses, including antiviral, antibacterial, and anticancer properties
- Consolidates insights into innovative drug formulation strategies and clinical trial outcomes for practical applications
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Verlagsort
Dateigröße
ISBN-13
978-0-443-43813-4 (9780443438134)
Schweitzer Klassifikation
Part I - Foundations of Chalcones research1. Natural sources of Chalcones2. Extraction methods from traditional to green approaches3. Structural and spectroscopic characterization of Chalcones4. Synthesis, structural modifications and scale-up methods5. Medicinal Chemistry Strategies in the Chalcone scaffold6. Chalcones as versatile intermediates in organic chemistry7. Chalcones in metal complexesPart II - Pharmacology of Chalcones8. PK properties and bioavailability of Chalcones9. Chalcone Toxicity10. Natural Chalcones in Traditional Medicine11. Chalcones as Antiviral Agents12. Chalcones as Antibacterial and Antitubercular Agents13. Anticancer Potential of Chalcones14. Chalcones as Neuroprotective and Anti-Alzheimer's Disease Agents15. Chalcones as Antiprotozoal, Antiparasitic and Insecticidal Agents16. Chalcones as Antifungal Agents17. Chalcones as Anti-inflammatory, Anti-ulcer and Antioxidant Agents18. Chalcones as Anti-hyperlipidemic, Anti-diabetic and Insulin Regulating AgentsPart III - Prospects19. Chalcone-containing Products (food supplements, nutraceuticals, functional food)20. Formulations and Drug Delivery of Chalcones21. Chalcone-protein co-crystals in the PDB22. Clinical Trials of Chalcone-based drug candidates